查看更多>>摘要：Eight phenolic compounds (1-8), including two new compounds (1 and 2), were isolated from the twigs of Gardenia jasminoides. Their structures were determined by means of extensive ID and 2D NMR spectroscopic studies. Compounds 1-4 were tested for their antirr.ethicillin-resistant Staphylococcus aureus (anti-MRSA) activity. The results revealed that compounds 1-4 showed good inhibition with IZD of 12.2 ± 2.2, 13.8 ± 2.4, 15.2 ± 2.8, and 12.9 ± 2.5 mm, respectively.
查看更多>>摘要：The marine derived fungus Alternaria alternata (Fr.) Keissl. was isolated from branch samples of Beibu Gulf, Qinzhou, Guangxi, China and identified by 16s rDNA. Chemical study of A. alternata led to the isolation of a new isomer compound named tricycloalternarene 18c and nine known compounds, including altemariol monomethyl ether, mannitol, cyclo(Gly-Ala), tenuazonic acid, allantoin, thymine, uracil, erythritol, and ergosterol. Their chemical structures were identified by extensive spectrum (IR, MS, ID, and 2D NMR spectra) and compared with the reported literature data.
查看更多>>摘要：A novel cyclopropanoid, 4-(2-(benzo[uf][l,3]dioxol-5-yl)cyclopropoxy)-2,6-dimethoxyphenol (1) was isolated from the stems of Cinnamomum osmophloeum (Lauraceae). The structure of the novel cyclopropanoid was elucidated by chemical and physical evidence.
查看更多>>摘要：Arugosin R (1), a new arugosin type metabolite, was isolated from Talaromyces flavus. Its structure was characterized by detailed analyses of 1R, MS, ID, and 2D NMR spectra. The antimicrobial activity against Escherichia coli, Staphylococcus aureus, Aspergillus niger, and Candida albicans was evaluated.
查看更多>>摘要：Окислением по Дэвису синтезировано 20 новых производных рупестоновой кислоты и установлена их противовирусная активность в отношении вируса гриппа A (H3N2). Показано, что некоторые синтезированные соединения проявляют антивирусную активность против вируса гриппа А. Доказано проявление наилучшей потенциальной активности соединения 4г (К=а-метилциннамил ацил соответственно с 1С50 1 4.37 мкг/мл и ТС50 8 0.13 мкг/мл) в отношении вируса гриппа А.
查看更多>>摘要：A new (3-ionone, burmanic acid A (1) was isolated from the roots of Cinnamomum burmanni (Nees & T. Nees) Blume (Lauraceae). The structure of the new [3-ionone was elucidated by chemical and physical evidence.
查看更多>>摘要：Two new isobenzofuranone derivatives (1 and 2) together with six known compounds (3-8) were isolated from the roots of Phlomis betonicoides, a highly sweet plant in China. Their structures were determined by means of HR-ESI-MS and extensive ID and 2D NMR spectroscopic studies. Compounds 1-8 were tested for their anti-rotavirus activity. The results showed that compounds 1-8 exhibited potent anti-rotavirus activity with therapeutic index value 7.5-16.4.
查看更多>>摘要：По реакции Виттига из 5-гидроксиметилфурфурола (5-HMF) и его производных с различными фосфоранами синтезированы новые еноны. Обнаружено, что полученные еноны могут влиять на процессы свободного радикального окисления в модельных системах, в частности, подавлять генерацию активных форм кислорода.
查看更多>>摘要：One new cycloartane-type triterpenoid, named 24-epimarkhacanasin С (1), together with four known flavonoids, apigenin (2), luteolin (3), apigenin 7-0-(3-D-glucopyranoside (4), and luteolin 7-0-f3-D-glucopyranoside (5), was isolated by various chromatographic methods from the ethyl acetate extract of Markhamia stipulata var. canaense leaves. Their structures were elucidated by IR, UV, HR-ESI-MS, and NMR experiments. All compounds were reported for the first time from this species. Their cytotoxicities were evaluated against human breast cancer cell line (MCF-7) by SRB assay. The isolated compounds 1, 3, and 4 exhibited significant cytotoxic activity (IC50 ranged from 53.38 to 68.32 ug/mL), while compounds 2 and .5 did not show activity.
查看更多>>摘要：На основе селективных превращений хлорангидрида ламбертиановой кислоты синтезированы новые производные лабданоидов, содержащие гидрофильные заместители (амино-, метиламино-) в положении С-4. Предложен однореакторный метод получения амида 16-формилламбертиановой кислоты, включающий селективное формилирование ламбертиановой кислоты хлорокисью фосфора в диметилформамиде и последующее амидирование водным аммиаком. Методом РСА исследована молекулярная структура соединения, У вновь синтезированных оксалатов 4-амино-1 8-нор-1 5Л6-эпоксилабда-8( 17), 13,14-триена, 4-(пирролидин-1 -ил)-18-нор-15,16-эпоксилабда-8(17),13,14-триена и амида 16-(гидроксиметил)ламбертиановой кислоты выявлена анальгетическая активность на модели химического раздражения.
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