查看更多>>摘要:The mulberry tree(Moms alba L.)is a species of Moms belonging to the Moracea family.The trees grow in Europe,West China,Korea,and Japan on a very large scale.Their leaves are very commonly utilized as feed of silkworms.The leaves of Moms plants can also be used as hypoglycemic,hypotensive,diuretic,and antimutagenic tonics(1).As a traditional Chinese medicine,mulberry leaves have been used to treat fever,protect the liver,and lower blood pressure for a long time(2).Previous studies have shown that mulberry leaves exhibit a variety of biological functions,including anti-obesity(3),antidiabetes(4),anti-oxidation(5),anti-inflammation(6),and anti-atherosclerosis(7).To date,a large number of flavones,benzofurans,and alkaloids have been isolated from mulberry leaves(8,9),but the chemical constituents of mulberry leaves and their bioactivities deserve to be further investigated.The MeOH extract of mulberry stems was subjected to solvent partitioning and chromatographic separation to afford eight pure flavonoids.The chemical constituents of mulberry stems were separated by column chromatography.Eight flavonoids,including,5,3'-dihydroxy-7,4'-dimethoxyflavone(1)(10),5-hydroxy-7,8,3',4'-tetramethoxyflavone(2)(11),5,8-dihydroxy-7,3',4'-trimethoxyflavone(3)(12),5,8-dihydroxy-7,4'-dimethoxyflavone(4)(13),5-hydroxy-7,3',4'-trimethoxyflavone(5)(14),3,5-dihydroxy-7,3',4',5'-tetramethoxyflavone(6)(15),5,4'-dihydroxy-7-methoxyflavone(7)(16),and 5,4'-dihydroxy-6,7-dimethoxyflavone(crisimaritin)(8)(17),were isolated from the stems of Moms alba.All of these compounds(1-8)were obtained for the first time from this plant and identified by direct comparison with authentic samples and literature(10-17).