查看更多>>摘要:By a News Reporter-Staff News Editor at Robotics & Machine Learning Daily News Daily News-New research on Artificial Intelligenc e is the subject of a report. According to news reporting from Nanjing, People's Republic of China, by NewsRx journalists, research stated, "This multicenter, d ouble-blinded, randomized controlled trial (RCT) aims to assess the impact of an artificial intelligence (AI)-based model on the efficacy of intracranial aneury sm detection in CT angiography (CTA) and its influence on patients' short-term a nd long-term outcomes. Prospective, multicenter, double-blinded RCT." Financial supporters for this research include National Natural Science Foundati on of China, Key Programme. The news correspondents obtained a quote from the research from Nanjing Universi ty, "The model was designed for the automatic detection of intracranial aneurysm s from original CTA images. Adult inpatients and outpatients who are scheduled f or head CTA scanning. Randomization groups: (1) Experimental Group: Head CTA int erpreted by radiologists with the assistance of the True-AI-integrated intracran ial aneurysm diagnosis strategy (True-AI arm). (2) Control Group: Head CTA inter preted by radiologists with the assistance of the Sham-AI-integrated intracrania l aneurysm diagnosis strategy (Sham-AI arm). Block randomization, stratified by center, gender, and age group. Coprimary outcomes of superiority in patient-leve l sensitivity and noninferiority in specificity for the True-AI arm to the Sham- AI arm in intracranial aneurysms. Diagnostic performance for other intracranial lesions, detection rates, workload of CTA interpretation, resource utilization, treatment-related clinical events, aneurysm-related events, quality of life, and cost-effectiveness analysis. Study participants and participating radiologists will be blinded to the intervention. Based on our pilot study, the patient-level sensitivity is assumed to be 0.65 for the Sham-AI arm and 0.75 for the True-AI arm, with specificities of 0.90 and 0.88, respectively. The prevalence of intrac ranial aneurysms for patients undergoing head CTA in the hospital is approximate ly 12%. To establish superiority in sensitivity and noninferiority in specificity with a margin of 5% using a one-sided a = 0.025 to ensure that the power of coprimary endpoint testing reached 0.80 and a 5% attrition rate, the sample size was determined to be 6450 in a 1:1 allocation to True-AI or Sham-AI arm. The study will determine the precise impact of the AI s ystem on the detection performance for intracranial aneurysms in a double-blinde d design and following the real-world effects on patients' short-term and long-t erm outcomes. This trial has been registered with the NIH, U.S."