查看更多>>摘要:By a News Reporter-Staff News Editor at Robotics & Machine Learning Daily News Daily News-New research on Oncology - Lung Cancer is the subject of a report. According to news reporting from Chengdu, People's Republic of China, by NewsRx journalists, research stated, "Metachronous second primary lung cancer (MSPLC) is not that rare but is seldom studied. We aim to co mpare real-world survival outcomes between different surgery strategies and radi otherapy for MSPLC." The news correspondents obtained a quote from the research from Sichuan Universi ty, "This retrospective study analyzed data collected from patients with MSPLC b etween 1988 and 2012 in the Surveillance, Epidemiology, and End Results (SEER) d atabase. Propensity score matching (PSM) analyses and machine learning were perf ormed to compare variables between patients with MSPLC. Survival curves were plo tted using the Kaplan-Meier method and were compared using log-rank tests. A tot al of 2451 MSPLC patients were categorized into the following treatment groups: 864 (35.3%) received radiotherapy, 759 (31 %) underwent surgery, 89 (3.6%) had surgery plus radiotherapy, and 739 (30.2% ) had neither treatment. After PSM, 470 pairs each for radiotherapy and surgery were generated. The surgery group had significantly better survival than the rad iotherapy group (P <.001) and the untreated group (563 pair s; P <.001). Further analysis revealed that both wedge resec tion (85 pairs; P=.004) and lobectomy (71 pairs; P=.002) outperformed radiothera py in overall survival for MSPLC patients. Machine learning models (extreme grad ient boosting, random forest classifier, adaptive boosting) demonstrated high pr edictive performance based on area under the curve (AUC) values. Least absolute shrinkage and selection operator (LASSO) regression analysis identified 9 signif icant variables impacting cancer-specific survival, emphasizing surgery's consis tent influence across 1 year to 10 years. These variables encompassed age at dia gnosis, sex, year of diagnosis, radiotherapy of initial primary lung cancer (IPL C), primary site, histology, surgery, chemotherapy, and radiotherapy of MPSLC. C ompeting risk analysis highlighted lower mortality for female MPSLC patients (ha zard ratio [HR]=0.79, 95% CI 0.71-0.87) and recent IPLC diagnoses (HR=0.79, 95 % CI 0.73-0.85), while radiotherapy for IPLC increased mortality (HR=1.31, 95% CI 1.16-1.50). Surgery alone had the lowest cancer-specific mortality (HR=0.83, 95% CI 0.81-0.85), with sublevel resection having the lowest mortality rate among th e surgical approaches (HR=0.26, 95% CI 0.21-0.31). The findings pr ovide valuable insights into the factors that influence cumulative cancer-specif ic mortality."