查看更多>>摘要:By a News Reporter-Staff News Editor at Robotics & Machine Learning Daily News Daily News-New research on Biomedical Engineering-Tissue Engineering is the subject of a report. According to news reporting ou t of Nanjing, People's Republic of China, by NewsRx editors, research stated, "A mino acid (AA) metabolism plays a vital role in liver regeneration. However, its measuring utility for post-hepatectomy liver regeneration under different condi tions remains unclear." Our news journalists obtained a quote from the research from China Pharmaceutica l University, "We aimed to combine machine learning (ML) models with AA metabolo mics to assess liver regeneration in health and non-alcoholic steatohepatitis (N ASH). The liver index (liver weight/body weight) was calculated following 70% hepatectomy in healthy and NASH mice. The serum levels of 39 amino acids were me asured using ultra-high performance liquid chromatography-tandem mass spectromet ry analysis. We used orthogonal partial least squares discriminant analysis to d etermine differential AAs and disturbed metabolic pathways during liver regenera tion. The SHapley Additive exPlanations algorithm was performed to identify pote ntial AA signatures, and five ML models including least absolute shrinkage and s election operator, random forest, K-nearest neighbor (KNN), support vector regre ssion, and extreme gradient boosting were utilized to assess the liver index. El even and twenty-two differential AAs were identified in the healthy and NASH gro ups, respectively. Among these metabolites, arginine and proline metabolism were commonly disturbed metabolic pathways related to liver regeneration in both gro ups. Five AA signatures were identified, including hydroxylysine, L-serine, 3-me thylhistidine, L-tyrosine, and homocitrulline in healthy group, and L-arginine, 2-aminobutyric acid, sarcosine, beta-alanine, and L-cysteine in NASH group. The KNN model demonstrated the best evaluation performance with mean absolute error, root mean square error, and coefficient of determination values of 0.0037, 0.00 47, 0.79 and 0.0028, 0.0034, 0.71 for the healthy and NASH groups, respectively. "