查看更多>>摘要:By a News Reporter-Staff News Editor at Robotics & Machine Learning Daily News Daily News – New research on Central Nervous System Diseases and Conditions - Epilepsy is the subject of a report. According to new s reporting from Jiangsu, People’s Republic of China, by NewsRx journalists, res earch stated, “Microstates represent the global and topographical distribution o f electrical brain activity from scalp-recorded EEG. This study aims to explore EEG microstates of patients with focal epilepsy prior to medication, and employ extracted microstate metrics for predicting treatment outcomes with Oxcarbazepin e monotherapy.” The news correspondents obtained a quote from the research from Southeast Univer sity, “This study involved 25 newly-diagnosed focal epilepsy patients (13 female s), aged 12 to 68, with various etiologies. Patients were categorized into Non-S eizure-Free (NSF) and Seizure-Free (SF) groups according to their first follow-u p outcomes. From pre-medication EEGs, four representative microstates were ident ified by using clustering. The temporal parameters and transition probabilities of microstates were extracted and analyzed to discern group differences. With ge nerating sample method, Support Vector Machine (SVM), Logistic Regression (LR), and Naive Bayes (NB) classifiers were employed for predicting treatment outcomes . In the NSF group, Microstate 1 (MS1) exhibited a significantly higher duration (mean±std. = 0.092±0.008 vs. 0.085±0.008, p = 0.047), occurrence (mean±std. = 2 .587±0.334 vs. 2.260±0.278, p = 0.014), and coverage (mean±std. = 0.240±0.046 vs . 0.194±0.040, p = 0.014) compared to the SF group. Additionally, the transition probabilities from Microstate 2 (MS2) and Microstate 3 (MS3) to MS1 were increa sed. In MS2, the NSF group displayed a stronger correlation (mean±std. = 0.618±0 .025 vs. 0.571±0.034, p<0.001) and a higher global explain ed variance (mean±std. = 0.083±0.035 vs. 0.055±0.023, p = 0.027) than the SF gro up. Conversely, Microstate 4 (MS4) in the SF group demonstrated significantly gr eater coverage (mean±std. = 0.388±0.074 vs. 0.334±0.052, p = 0.046) and more fre quent transitions from MS2 to MS4, indicating a distinct pattern. Temporal param eters contribute major predictive role in predicting treatment outcomes of Oxcar bazepine, with area under curves (AUCs) of 0.95, 0.70, and 0.86, achieved by LR, NB and SVM, respectively.”