查看更多>>摘要:By a News Reporter-Staff News Editor at Robotics & Machine Learning Daily News Daily News-New research on Reproductive Medicine - Female Infertility is the subject of a report. According to news reporting ori ginating in Stockholm, Sweden, by NewsRx journalists, research stated, "To use m achine learning methods to develop prediction models of pregnancy complications in women that conceived with Assisted Reproductive Techniques (ART). A nation-wi de register-based cohort study with prospectively collected data. all nulliparou s women who achieved birth within the first three ART treatment cycles between 2 008 and 2016 in Sweden." The news reporters obtained a quote from the research from Karolinska Institute, "Characteristics prior to use of ART, such as demographics and medical history were considered as potential predictors in the development of pre-treatment pred iction models. ART treatment details were further included in post-treatment pre diction models. Potential diagnoses of preeclampsia, placental complications (pr evia, accreta, and abruption), and postpartum hemorrhage were identified using t he international classification of diseases (ICD) recorded in the Swedish Medica l Birth and Patient registers respectively. Multiple prediction model algorithms were performed and compared for each outcome and treatment cycle, including log istic regression, decision tree model, naive Bayes classification, support vecto r machine, random forest, and gradient boosting. The performance of each model w as assessed with C statistic and nested crossvalidation was used to aid model s election and hyperparameter tunning. A total of 14,732 women gave birth after th e first (N=7302), second (N=4688) or third (N=2742) ART cycle, representing birt h rates of 24.1%, 23.8%, and 22.0%. Overa ll prediction performance did not vary much across the different methods used. I n the first cycle, the pre-treatment prediction performance was at best 66% , 66% and 60 % for pre-eclampsia, placental complicat ions and postpartum hemorrhage respectively. Inclusion of posttreatment charact eristics conferred slight improvement (around 1-5%), as did predict ion in later cycles (around 1-5%). The top influential and consiste nt predictors included age, region of residence, infertility diagnosis, and type of embryo transfer (fresh or frozen) in the later (2 and 3) cycles. Body Mass I ndex was a top predictor of preeclampsia, and influential also for placental com plications but not for postpartum hemorrhage. The combined use of demographics, medical history, and ART treatment information was not enough to confidently pre dict serious pregnancy complications in women that conceived with ART."