查看更多>>摘要:By a News Reporter-Staff News Editor at Robotics & Machine Learning Daily News Daily News-New research on Oncology - Chondrosarc oma is the subject of a report. According to news originating from Rome, Italy, by NewsRx correspondents, research stated, "Atypical cartilaginous tumour (ACT) and high-grade chondrosarcoma (CS) of long bones are respectively managed with a ctive surveillance or curettage and wide resection. Our aim was to determine dia gnostic performance of X-rays radiomics-based machine learning for classificatio n of ACT and high-grade CS of long bones." Financial support for this research came from Associazione Italiana per la Ricer ca sul Cancro. Our news journalists obtained a quote from the research from IRCCS Regina Elena National Cancer Institute, "This retrospective, IRB-approved study included 150 patients with surgically treated and histology-proven lesions at two tertiary bo ne sarcoma centres. At centre 1, the dataset was split into training (n = 71 ACT , n = 24 high-grade CS) and internal test (n = 19 ACT, n = 6 high-grade CS) coho rts, respectively, based on the date of surgery. At centre 2, the dataset consti tuted the external test cohort (n = 12 ACT, n = 18 high-grade CS). Manual segmen tation was performed on frontal view X-rays, using MRI or CT for preliminary ide ntification of lesion margins. After image pre-processing, radiomic features wer e extracted. Dimensionality reduction included stability, coefficient of variati on, and mutual information analyses. In the training cohort, after class balanci ng, a machine learning classifier (Support Vector Machine) was automatically tun ed using nested 10-fold cross-validation. Then, it was tested on both the test c ohorts and compared to two musculoskeletal radiologists' performance using McNem ar's test. Five radiomic features (3 morphology, 2 texture) passed dimensionalit y reduction. After tuning on the training cohort (AUC = 0.75), the classifier ha d 80%, 83%, 79% and 80%, 89 %, 67% accuracy, sensitivity, and specificity in the internal (temporally independent) and external (geographically independent) test cohorts, respectively, with no difference compared to the radiologists (p 0.617 )."