查看更多>>摘要:New research on Machine Learning is th e subject of a report. According to news reporting out of Caen, France, by NewsR x editors, research stated, "X-ray and proton irradiation have been reported to induce distinct modifications in cytokine expression in vitro and in vivo, sugge sting a dissimilar inflammatory response between X-rays and protons. We aimed to investigate the differences in cytokine profiles early following fractionated b rain irradiation with X-rays or protons and their relationship with leukocyte su bpopulations in rodents." Our news journalists obtained a quote from the research from Universite de Caen Normandie, "Our study utilized data from 80 tumor-free mice subjected to X-ray o r proton brain irradiation in four fractions of 2.5Gy. Sixteen non-irradiated mi ce were used as the controls. Blood was collected 12h postirradiation to examine the profile of 13 cytokines. Correlation analysis, principal component analysis (PCA), and tree-based modeling were used to investigate the relationship betwee n cytokine levels and leukocyte subpopulation variations following irradiation i n the blood. Regardless of the irradiation type, brain irradiation resulted in a notable elevation in the plasma levels of IFN-g and MCP-1. The use of either Xray or proton beam had differential effect on plasma cytokine levels following b rain irradiation. Specifically, X-ray irradiation was associated with significan tly increased plasma levels of IFN-b, IL-12p70, and IL-23, along with a decrease d level of IL-1a, in comparison to proton irradiation. Correlation analysis reve aled distinct cytokine regulatory patterns between X-ray and proton brain irradi ation. PCA highlighted the association of MCP-1, IL-6, TNF-a, IL-17A, and IFN-g with neutrophils, monocytes, and naive T-cells following X-ray irradiation. TNF-a and IL-23 levels correlated with naive CD4+-cells following proton irradiation . Tree-based models demonstrated that high TNF-a level resulted in an increase i n naive T-cells, neutrophils, and monocytes, whereas low IL-6 level was associat ed with decreases in these cell counts. Our findings revealed distinct inflammat ory responses induced by X-ray irradiation in contrast to proton brain irradiati on, as demonstrated by the differential regulation of cytokines in the bloodstre am. Moreover, the study highlighted the association between specific cytokine le vels and various leukocyte subpopulations."