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工程（英文）
工程（英文）

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2095-8099

工程（英文）/Journal EngineeringCSTPCDCSCD北大核心SCI
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    The Notch Signaling Pathway:Mechanistic Insights in Health and Disease

    Yao MengZhihan BoXinyi FengXinyi Yang...
    212-232页
    查看更多>>摘要：The Notch signaling pathway is evolutionarily conserved across metazoan species and plays key roles in many physiological processes.The Notch receptor is activated by two families of canonical ligands(Delta-like and Serrate/Jagged)where both ligands and receptors are single-pass transmembrane proteins usu-ally with large extracellular domains,relative to their intracellular portions.Upon interaction of the core binding regions,presented on opposing cell surfaces,formation of the receptor/ligand complex initiates force-mediated proteolysis,ultimately releasing the transcriptionally-active Notch intracellular domain.This review focuses on structural features of the extracellular receptor/ligand complex,the role of post-translational modifications in tuning this complex,the contribution of the cell membrane to ligand func-tion,and insights from acquired and genetic diseases.
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    • NSTL
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    Characteristics Analysis of Integrated CAES and CFPP Trigeneration System Considering Working Conditions and Application Scenarios

    Jiajia LiPeigang YanGuowen ZhouXingshuo Li...
    233-245页
    查看更多>>摘要：To meet the goal of worldwide decarbonization,the transformation process toward clean and green energy structures has accelerated.In this context,coal-fired power plant(CFPP)and large-scale energy storage represented by compressed air energy storage(CAES)technology,are tasked with increasing renewable resource accommodation and maintaining the power system security.To achieve this,this paper proposes the concept of a CFPP-CAES combined cycle and a trigenerative system based on that.Considering the working conditions of the CFPP,thermal characteristics of three typical operation modes were studied and some general regularities were identified.The results of various potential integration schemes discussion indicated that extracting water from low-temperature points in the feedwater sys-tem to cool pressurized air and simultaneously increase the backwater temperature is beneficial for improving performance.In addition,preheating the pressurized air before the air expanders via low-grade water in the feedwater system as much as possible and reducing extracted steam contribute to increasing the efficiency.With the optimal integration scheme,2.85 tonnes of coal can be saved per cycle and the round-trip efficiency can be increased by 2.24％.Through the cogeneration of heat and power,the system efficiency can reach 77.5％.In addition,the contribution degree of the three compression heat uti-lization methods to the performance improvement ranked from high to low,is preheating the feedwater before the boiler,supplying heat,and flowing into the CFPP feedwater system.In the cooling energy gen-eration mode,the system efficiency can be increased to over 69％.Regardless of the operation mode,the benefit produced by integration is further enhanced when the CFPP operates at higher operating condi-tions because the coupling points parameters are changed.In addition,the dynamic payback period can be shortened by 11.33 years and the internal rate of return increases by 5.20％under a typical application scenario.Regarding the effect of different application scenarios in terms of economics,investing in the proposed system is more appropriate in regions with multiple energy demands,especially heating demand.These results demonstrate the technical advantages of the proposed system and provide guiding principles for its design,operation,and project investment.
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    Advanced Compressed Air Energy Storage Systems:Fundamentals and Applications

    Xinjing ZhangZiyu GaoBingqian ZhouHuan Guo...
    246-269页
    查看更多>>摘要：Decarbonization of the electric power sector is essential for sustainable development.Low-carbon gener-ation technologies,such as solar and wind energy,can replace the CO2-emitting energy sources(coal and natural gas plants).As a sustainable engineering practice,long-duration energy storage technologies must be employed to manage imbalances in the variable renewable energy supply and electricity demand.Compressed air energy storage(CAES)is an effective solution for balancing this mismatch and therefore is suitable for use in future electrical systems to achieve a high penetration of renewable energy generation.This study introduces recent progress in CAES,mainly advanced CAES,which is a clean energy technology that eliminates the use of fossil fuels,compared with two commercial CAES plants at Huntorf and McIntosh which are conventional ones utilizing fossil fuels.Advanced CAES include adiabatic CAES,isothermal CAES,liquid air energy storage,supercritical CAES,underwater CAES,and CAES coupled with other technologies.The principles and configurations of these advanced CAES technologies are briefly discussed and a comprehensive review of the state-of-the-art technologies is presented,including theoretical studies,experiments,demonstrations,and applications.The comparison and discussion of these CAES technologies are summarized with a focus on technical maturity,power sizing,storage capac-ity,operation pressure,round-trip efficiency,efficiency of the components,operation duration,and investment cost.Potential application trends were compiled.This paper presents a comprehensive refer-ence for developing novel CAES systems and makes recommendations for future research and develop-ment to facilitate their application in several areas,ranging from fundamentals to applications.
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