查看更多>>摘要：Cryptosporidium is an emerging single-cell zoonotic pathogen. By invading human and animal small intestinal epithelial cells, the host produces a variety of clinical symptoms, mainly diarrhea. Spores of Cryptosporidium can be transmitted through water-borne, food-borne, and mutual transmission between hosts, which has important public health significance. Studies have shown that non-human primates can be infected with multiple Cryptosporidium genotypes. Moreover, this species has a high genetic similarity with humans, so it needs to be taken seriously. This article reviews the infection rates, genotypes, and zoonotic risk of Cryptosporidium in non-human primates.
查看更多>>摘要：In the state of acute myocardial ischemia, miRNA expression can regulate related genes and proteins, reduce myocardial cell damage, and thus play a protective role in the myocardium. However, the specific mechanism still needs to be further explored. Recent studies have found that the opening of the mitoKATP channel can regulate mitochondrial autophagy, and the initiation of miRNA-DNA methylation plays a regulatory role in inducing cell autophagy. The applicant research team previously found that Qishen Yiqi Dropping Pills could significantly improve myocardial ischemia by mediating MitokATP channels to regulate mitochondrial autophagy., and animal experiments have confirmed that miR-155 plays a significant role in the aspect of autophagy regulates, inflammatory reaction and Vascular smooth muscle cell migration. Therefore, the applicant innovatively proposed that Qishen Yiqi Dropping Pills can regulate miRNA155-DNA methylation to mediate the opening of mitoKATP, thereby regulating mitochondrial autophagy and improving myocardial ischemia. In this paper, the association between mitochondrial autophagy and oxidative stress injury after myocardial ischemia was described, and the possible mechanism of Qisen Yiqi dropping pills regulating mitochondrial autophagy by regulating miRNA155-DNA methylation to mediate MitokATP to improve myocardial ischemia reperfusion injury was discussed, so as to provide theoretical ideas for related research.
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