首页|A theoretical study of miRNA155-DNA methylation mediated mitokATP regulating mitochondrial autophagy in the improvement of myocardial ischemia-reperfusion injury by Qishen Yiqi Dropping Pills

A theoretical study of miRNA155-DNA methylation mediated mitokATP regulating mitochondrial autophagy in the improvement of myocardial ischemia-reperfusion injury by Qishen Yiqi Dropping Pills

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In the state of acute myocardial ischemia, miRNA expression can regulate related genes and proteins, reduce myocardial cell damage, and thus play a protective role in the myocardium. However, the specific mechanism still needs to be further explored. Recent studies have found that the opening of the mitoKATP channel can regulate mitochondrial autophagy, and the initiation of miRNA-DNA methylation plays a regulatory role in inducing cell autophagy. The applicant research team previously found that Qishen Yiqi Dropping Pills could significantly improve myocardial ischemia by mediating MitokATP channels to regulate mitochondrial autophagy., and animal experiments have confirmed that miR-155 plays a significant role in the aspect of autophagy regulates, inflammatory reaction and Vascular smooth muscle cell migration. Therefore, the applicant innovatively proposed that Qishen Yiqi Dropping Pills can regulate miRNA155-DNA methylation to mediate the opening of mitoKATP, thereby regulating mitochondrial autophagy and improving myocardial ischemia. In this paper, the association between mitochondrial autophagy and oxidative stress injury after myocardial ischemia was described, and the possible mechanism of Qisen Yiqi dropping pills regulating mitochondrial autophagy by regulating miRNA155-DNA methylation to mediate MitokATP to improve myocardial ischemia reperfusion injury was discussed, so as to provide theoretical ideas for related research.

Qishen Yiqi Dropping PillsMyocardial ischemiaMiRNA155-DNA methylationMitochondrial autophagyMitoKATP

Gui-Xin He、Yu-Fei Feng、Wei-Bin Qin、Lin Lin、Meng-Xian Hu、Guo-Kun Zheng、Li-Yan Yu、Zi-Yong Jia、Juan Wei、Qi Wen、Zhen-Le Huang、Shi-Hai Liu

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The First Affiliated Hospital of Guangxi University of Chinese Medicine,Nanning 530022,China

Guangxi University of Chinese Medicine,Nanning 530299,China

Regional Fund Project of National Natural Science Foundation of ChinaYoung and Middle-aged Teachers'Scientific Research Basic Ability Enhancement Project of Guangxi UniversitiesGuangxi Graduate Education Innovation Program

814607122020KY07026YCXJ2021035

2022

海南医科大学学报(英文版)

海南医科大学学报(英文版)

ISSN：
年,卷(期)：2022.28(5)
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