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科学通报（英文版）
科学通报（英文版）

周光召

旬刊

1001-6538

csb@scichina.com

010-64036120

100717

北京东黄城根北街16号

科学通报（英文版）/Journal Chinese Science BulletinEISCI
查看更多>>《科学通报》创刊于1950年，是中国科学院主办、中国科学杂志社承办的自然科学综合性学术刊物，报道自然科学各学科基础理论和应用研究方面具有创新性和和高水平的、具有重要意义的最新研究成果，要求文章的可读性强，能在一个比较宽范的学术领域产生深刻的影响。我们的目标是：成为国内外读者了解中国乃至世界范围的自然科学各研究领域最新成果的主要窗口之一。《科学通报》进入了国际上主要检索系统，如CA，EI，日本《科技速报》和美国科学信息研究所（ISI）的以下系统：Science Citation Index(SCI-CDE)，SCISearch，Current Contents(PC&E)和Research Alert。
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    Exploration of individual colorectal cancer cell responses to H2O2 eustress using hopping probe scanning ion conductance microscopy

    Dong WangEmily WoodcockXi YangHiromi Nishikawa...
    1909-1919页
    查看更多>>摘要：Colorectal cancer(CRC),a widespread malignancy,is closely associated with tumor microenvironmental hydrogen peroxide(H2O2)levels.Some clinical trials targeting H2O2 for cancer treatment have revealed its paradoxical role as a promoter of cancer progression.Investigating the dynamics of cancer cell H2O2 eustress at the single-cell level is crucial.In this study,non-contact hopping probe mode scanning ion conductance microscopy(HPICM)with high-sensitive Pt-functionalized nanoelectrodes was employed to measure dynamic extracellular to intracellular H2O2 gradients in individual colorectal cancer Caco-2 cells.We explored the relationship between cellular mechanical properties and H2O2 gradients.Exposure to 0.1 or 1 mmol/L H2O2 eustress increased the extracellular to intracellular H2O2 gradient from 0.3 to 1.91 or 3.04,respectively.Notably,cellular F-actin-dependent stiffness increased at 0.1 mmol/L but decreased at 1 mmol/L H2O2 eustress.This H2O2-induced stiffness modulated AKT activation posi-tively and glutathione peroxidase 2(GPX2)expression negatively.Our findings unveil the failure of some H2O2-targeted therapies due to their ineffectiveness in generating H2O2,which instead acts eustress to promote cancer cell survival.This research also reveals the complex interplay between physical proper-ties and biochemical signaling in cancer cells'antioxidant defense,illuminating the exploitation of H2O2 eustress for survival at the single-cell level.Inhibiting GPX and/or catalase(CAT)enhances the cytotoxic activity of H2O2 eustress against CRC cells,which holds significant promise for developing innovative therapies targeting cancer and other H2O2-related inflammatory diseases.
      原文链接:
    • NETL
    • NSTL
    • 万方数据

    Ethanolamine as a biomarker and biomarker-based therapy for diabetic retinopathy in glucose-well-controlled diabetic patients

    Guangyi HuLiping GuRuonan WangQizhi Jian...
    1920-1935页
    查看更多>>摘要：Diabetic retinopathy(DR)is the leading cause of blindness among the working-age population.Although controlling blood glucose levels effectively reduces the incidence and development of DR to less than 50％,there are currently no diagnostic biomarkers or effective treatments for DR development in glucose-well-controlled diabetic patients(GW-DR).In this study,we established a prospective GW-DR cohort by strictly adhering to glycemic control guidelines and maintaining regular retinal examinations over a median 2-year follow-up period.The discovery cohort encompassed 71 individuals selected from a pool of 292 recruited diabetic patients at baseline,all of whom consistently maintained hemoglobin A1c(HbA1c)levels below 7％without experiencing hypoglycemia.Within this cohort of 71 individuals,21 subsequently experienced new-onset GW-DR,resulting in an incidence rate of 29.6％.In the validation cohort,we also observed a significant GW-DR incidence rate of 17.9％.Employing targeted metabolomics,we investigated the metabolic characteristics of serum in GW-DR,revealing a significant association between lower levels of ethanolamine and GW-DR risk.This association was corroborated in the validation cohort,exhibiting superior diagnostic performance in distinguishing GW-DR from diabetes compared to the conventional risk factor HbA1c,with AUCs of 0.954 versus 0.506 and 0.906 versus 0.521 in the discovery and validation cohorts,respectively.Furthermore,in a streptozotocin(STZ)-induced diabetic rat model,ethanolamine attenuated diabetic retinal inflammation,accompanied by suppression of microglial diacylglycerol(DAG)-dependent protein kinase C(PKC)pathway activation.In conclusion,we propose that ethanolamine is a potential biomarker and represents a viable biomarker-based therapeutic option for GW-DR.
      原文链接:
    • NETL
    • NSTL
    • 万方数据

    P53 upregulation by USP7-engaging molecular glues

    Zhaoyang LiZiying WangChao ZhongHang Zhang...
    1936-1953页
    查看更多>>摘要：Molecular glues are typically small chemical molecules that act at the interface between a target protein and degradation machinery to trigger ternary complex formation.Identifying molecular glues is challeng-ing.There is a scarcity of target-specific upregulating molecular glues,which are highly anticipated for numerous targets,including P53.P53 is degraded in proteasomes through polyubiquitination by specific E3 ligases,whereas deubiquitinases(DUBs)remove polyubiquitination conjugates to counteract these E3 ligases.Thus,small-molecular glues that enhance P53 anchoring to DUBs may stabilize P53 through deu-biquitination.Here,using small-molecule microarray-based technology and unbiased screening,we iden-tified three potential molecular glues that may tether P53 to the DUB,USP7,and elevate the P53 level.Among the molecular glues,bromocriptine(BC)is an FDA-approved drug with the most robust effects.BC was further verified to increase P53 stability via the predicted molecular glue mechanism engaging USP7.Consistent with P53 upregulation in cancer cells,BC was shown to inhibit the proliferation of cancer cells in vitro and suppress tumor growth in a xenograft model.In summary,we established a potential screening platform and identified potential molecular glues upregulating P53.Similar strategies could be applied to the identification of other types of molecular glues that may benefit drug discovery and chemical biology studies.
      原文链接:
    • NETL
    • NSTL
    • 万方数据

    Effectiveness and safety of Sanhan Huashi granules versus nirmatrelvir-ritonavir in adult patients with COVID-19:A randomized,open-label,multicenter trial

    Xiaohui ZouKang ChangGuohui FanHuanwei Zheng...
    1954-1963页
    查看更多>>摘要：Sanhan Huashi granules(SHG)demonstrated therapeutic effects against coronavirus disease 2019(COVID-19)in observational studies.In order to compare the effectiveness and safety of SHG and nirma-trelvir-ritonavir in treating adults with mild-to-moderate COVID-19,we conducted a randomized,active-controlled,open-label,multi-center trial conducted between February and July in 2023.The patients were randomized in a 1∶1 ratio to the SHG group and the nirmatrelvir-ritonavir group.A total of 400 participants were randomized,among which 200 participants ultimately received SHG and 198 received nirmatrelvir-ritonavir.The primary outcome was time to sustained clinical recovery through day 28.SHG significantly shortened the median time to sustained clinical recovery compared to nirmatrelvir-riton-avir(6.0(95％CI,5.0 to 6.0)vs.8.0(95％Cl,6.0 to 9.0)d;P=0.001),particularly for individual symptoms including fever,sore throat,cough and fatigue.No participants in either group died and incidence of severe COVID-19 showed no difference between two groups.Participants who received nirmatrelvir-ritonavir demonstrated a higher rate of virus clearance on day 5 compared to those received SHG(46.4％(95％CI,39.1 to 53.7)vs.65.6％(95％CI,58.3 to 72.4);P＜0.001).Most adverse events were mild in both groups.In summary,SHG was superior to nirmatrelvir-ritonavir in shortening the time to sustained clinical recovery in participants with mild-to-moderate COVID-19,despite a lower virus clear-ance rate observed after 5 d of treatment(Chinese Clinical Trial Registry Identifier:ChiCTR2300067872).
      原文链接:
    • NETL
    • NSTL
    • 万方数据

    Mechanical protein polycystin-1 directly regulates osteoclastogenesis and bone resorption

    Mei HuangJingxuan ZhouXiaoxiao LiRan Liu...
    1964-1979页
    查看更多>>摘要：Mechanical loading is required for bone homeostasis,but the underlying mechanism is still unclear.Our previous studies revealed that the mechanical protein polycystin-1(PC1,encoded by Pkd1)is critical for bone formation.However,the role of PC1 in bone resorption is unknown.Here,we found that PC1 directly regulates osteoclastogenesis and bone resorption.The conditional deletion of Pkd1 in the osteo-clast lineage resulted in a reduced number of osteoclasts,decreased bone resorption,and increased bone mass.A cohort study of 32,500 patients further revealed that autosomal dominant polycystic kidney dis-ease,which is mainly caused by loss-of-function mutation of the PKD1 gene,is associated with a lower risk of hip fracture than those with other chronic kidney diseases.Moreover,mice with osteoclast-specific knockout of Pkd1 showed complete resistance to unloading-induced bone loss.A mechanistic study revealed that PC1 facilitated TAZ nuclear translocation via the C-terminal tail-TAZ complex and that conditional deletion of Taz in the osteoclast lineage resulted in reduced osteoclastogenesis and increased bone mass.Pharmacological regulation of the PC1-TAZ axis alleviated unloading-and estrogen deficiency-induced bone loss.Thus,the PC1-TAZ axis may be a potential therapeutic target for osteoclast-related osteoporosis.
      原文链接:
    • NETL
    • NSTL
    • 万方数据

    A doubled increasing trend of evapotranspiration on the Tibetan Plateau

    Xuelong ChenLing YuanYaoming MaDeliang Chen...
    1980-1990页
    查看更多>>摘要：Estimation of evapotranspiration(ETa)change on the Tibetan Plateau(TP)is essential to address the water requirement of billions of people surrounding the TP.Existing studies have shown that ETa estimations on the TP have a very large uncertainty.In this article,we discuss how to more accurately quantify ETa amount and explain its change on the TP.ETa change on the TP can be quantified and explained based on an ensem-ble mean product from climate model simulations,reanalysis,as well as ground-based and satellite obser-vations.ETa on the TP experienced a significant increasing trend of around 8.4±2.2 mm(10 a)-1(mean±one standard deviation)during 1982-2018,approximately twice the rate of the global land ETa(4.3±2.1 mm(10 a)-1).Numerical attribution analysis revealed that a 53.8％TP area with the increased ETa was caused by increased temperature and 23.1％part was due to soil moisture rising,because of the warming,melting cryosphere,and increased precipitation.The projected future increase in ETa is expected to cause a continued acceleration of the water cycle until 2100.
      原文链接:
    • NETL
    • NSTL
    • 万方数据

    Spartina alterniflora invasion benefits blue carbon sequestration in China

    Jingfan ZhangDehua MaoJihua LiuYaping Chen...
    1991-2000页
    查看更多>>摘要：Spartina alterniflora has rapidly and extensively encroached on China's coastline over the past decades.Among the coastal areas invaded by S.alterniflora,at most 93％are mudflats.However,the effect of S.alterniflora invasion on soil organic carbon(SOC)stocks of coastal mudflats has not been systematically studied on a national scale.Here,we quantified the nationwide changes in SOC stocks in coastal mudflats associated with S.alterniflora invasion between 1990 and 2020.We found that S.alterniflora invasion sig-nificantly enhanced SOC stocks in coastal China.Nonetheless,the benefit of S.alterniflora invasion of coastal SOC stock may be weakened by continuing human intervention.We found that S.alterniflora invading mudflats added 2.3 Tg SOC stocks to China's coastal blue carbon,while 1.78 Tg SOC stocks were lost mainly due to human activities,resulted in a net SOC stock gain of 0.52 Tg C.These findings over-turned the traditionally thought that S.alterniflora invasion would reduce ecosystem services by high-lighting that the historical invasion of S.alterniflora has broadly and consistently enhanced blue carbon stock in coastal China.
      原文链接:
    • NETL
    • NSTL
    • 万方数据