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科学通报（英文版）
科学通报（英文版）

周光召

旬刊

1001-6538

csb@scichina.com

010-64036120

100717

北京东黄城根北街16号

科学通报（英文版）/Journal Chinese Science BulletinEISCI
查看更多>>《科学通报》创刊于1950年，是中国科学院主办、中国科学杂志社承办的自然科学综合性学术刊物，报道自然科学各学科基础理论和应用研究方面具有创新性和和高水平的、具有重要意义的最新研究成果，要求文章的可读性强，能在一个比较宽范的学术领域产生深刻的影响。我们的目标是：成为国内外读者了解中国乃至世界范围的自然科学各研究领域最新成果的主要窗口之一。《科学通报》进入了国际上主要检索系统，如CA，EI，日本《科技速报》和美国科学信息研究所（ISI）的以下系统：Science Citation Index(SCI-CDE)，SCISearch，Current Contents(PC&E)和Research Alert。
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    Concurrence of high dust aerosol and stratosphere-intruded ozone pollution in super sandstorms

    Zhixiong ChenJane LiuXiushu QieXugeng Cheng...
    2509-2513页
      原文链接:
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    Universal materials model of deep-learning density functional theory Hamiltonian

    Yuxiang WangYang LiZechen TangHe Li...
    2514-2521页
    查看更多>>摘要：Realizing large materials models has emerged as a critical endeavor for materials research in the new era of artificial intelligence,but how to achieve this fantastic and challenging objective remains elusive.Here,we propose a feasible pathway to address this paramount pursuit by developing universal materials models of deep-learning density functional theory Hamiltonian(DeepH),enabling computational model-ing of the complicated structure-property relationship of materials in general.By constructing a large materials database and substantially improving the DeepH method,we obtain a universal materials model of DeepH capable of handling diverse elemental compositions and material structures,achieving remarkable accuracy in predicting material properties.We further showcase a promising application of fine-tuning universal materials models for enhancing specific materials models.This work not only demonstrates the concept of DeepH's universal materials model but also lays the groundwork for devel-oping large materials models,opening up significant opportunities for advancing artificial intelligence-driven materials discovery.
      原文链接:
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    Evidence of abnormal hot carrier thermalization at van Hove singularity of twisted bilayer graphene

    Nianze ShangChen HuangQing ChenChang Liu...
    2522-2528页
    查看更多>>摘要：Interlayer twist evokes revolutionary changes to the optical and electronic properties of twisted bilayer graphene(TBG)for electronics,photonics and optoelectronics.Although the ground state responses in TBG have been vastly and clearly studied,the dynamic process of its photoexcited carrier states mainly remains elusive.Here,we unveil the photoexcited hot carrier dynamics in TBG by time-resolved ultrafast photoluminescence(PL)autocorrelation spectroscopy.We demonstrate the unconventional ultrafast PL emission between the van Hove singularities(VHSs)with a～4 times prolonged relaxation lifetime.This intriguing photoexcited carrier behavior is ascribed to the abnormal hot carrier thermalization brought by bottleneck effects at VHSs and interlayer charge distribution process.Our study on hot carrier dynamics in TBG offers new insights into the excited states and correlated physics of graphene twistron-ics systems.
      原文链接:
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    Cu-optimized long-range interaction between Co nanoparticles and Co single atoms:Improved Fenton-like reaction activity

    Fan MoZelin HouQixing ZhouXixi Chen...
    2529-2542页
    查看更多>>摘要：The interplay between multi-atom assembly configurations and single atoms(SAs)has been gaining attention in research.However,the effect of long-term range interactions between SAs and multi-atom assemblies on the orbital filling characteristics has yet to be investigated.In this context,we introduced copper(Cu)doping to strengthen the interaction between cobalt(Co)nanoparticles(NPs)and Co SAs by promoting the spontaneous formation of Co-Cu alloy NPs that tends toward aggregation owing to its neg-ative cohesive energy(-0.06454),instead of forming Cu SAs.The incorporation of Cu within the Co-Cu alloy NPs,compared to the pure Co NPs,significantly expedites the kinetics of peroxymonosulfate(PMS)oxidation processes on Co SAs.Unlike Co NPs,Co-Cu NPs facilitate electron rearrangement in the d orbi-tals(especially dz2 and dxz)near the Fermi level in Co SAs,thereby optimizing the dz2-O(PMS)and dxz-O(SO5)orbital interaction.Eventually,the Co-Cu alloy NPs embedded in nitrogen-doped carbon(CC@CNC)catalysts rapidly eliminated 80.67％of 20 mg L-1 carbamazepine(CBZ)within 5 min.This performance significantly surpasses that of catalysts consisting solely of Co NPs in a similar matrix(C@CNC),which achieved a 58.99％reduction in 5 min.The quasi in situ characterization suggested that PMS acts as an electron donor and will transfer electrons to Co SAs,generating 1O2 for contaminant abatement.This study offers valuable insights into the mechanisms by which composite active sites formed through multi-atom assembly interact at the atomic orbital level to achieve high-efficiency PMS-based advanced oxidation processes at the atomic orbital level.
      原文链接:
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    Renewable biomass reinvigorates sustainable water-energy nexus

    Hongxu ChenJiatao XuZhiyong Jason RenHailong Lin...
    2543-2554页
    查看更多>>摘要：The water-energy nexus has garnered worldwide interest.Current dual-functional research aimed at co-producing freshwater and electricity faces significant challenges,including sub-optimal capacities("1+1＜2"),poor inter-functional coordination,high carbon footprints,and large costs.Mainstream water-to-electricity conversions are often compromised owing to functionality separation and erratic gradients.Herein,we present a sustainable strategy based on renewable biomass that addresses these issues by jointly achieving competitive solar-evaporative desalination and robust clean electricity generation.Using hydrothermally activated basswood,our solar desalination exceeded the 100％efficiency bottle-neck even under reduced solar illumination.Through simple size-tuning,we achieved a high evaporation rate of 3.56 kg h-1 m-2 and an efficiency of 149.1％,representing 128％-251％of recent values without sophisticated surface engineering.By incorporating an electron-ion nexus with interfacial Faradaic elec-tron circulation and co-ion-predominated micro-tunnel hydrodynamic flow,we leveraged free energy from evaporation to generate long-term electricity(0.38 W m-3 for over 14 d),approximately 322％of peer performance levels.This inter-functional nexus strengthened dual functionalities and validated gen-eral engineering practices.Our presented strategy holds significant promise for global human-society-environment sustainability.
      原文链接:
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    Tailoring component incorporation for homogenized perovskite solar cells

    Wenhan YangJunmin XiaYuexin LinHao Gu...
    2555-2564页
    查看更多>>摘要：Deep-level traps at the buried interface of perovskite and energy mismatch problems between the per-ovskite layer and heterogeneous interfaces restrict the development of ideal homogenized films and effi-cient perovskite solar cells(PSCs)using the one-step spin-coating method.Here,we strategically employed sparingly soluble germanium iodide as a homogenized bulk in-situ reconstruction inducing material preferentially aggregated at the perovskite buried interface with gradient doping,markedly reducing deep-level traps and withstanding local lattice strain,while minimizing non-radiative recombi-nation losses and enhancing the charge carrier lifetime over 9 μs.Furthermore,this gradient doping assisted in modifying the band diagram at the buried interface into a desirable flattened alignment,sub-stantially mitigating the energy loss of charge carriers within perovskite films and improving the carrier extraction equilibrium.As a result,the optimized device achieved a champion power conversion effi-ciency of 25.24％with a fill factor of up to 84.65％,and the unencapsulated device also demonstrated excellent light stability and humidity stability.This work provides a straightforward and reliable homog-enization strategy of perovskite components for obtaining efficient and stable PSCs.
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    An emerging antibacterial nanovaccine for enhanced chemotherapy by selectively eliminating tumor-colonizing bacteria

    Linfu ChenZheyu KangJingjing ShenRui Zhao...
    2565-2579页
    查看更多>>摘要：Fusobacterium nucleatum(F.nucleatum),an oral anaerobe,is prevalent in colorectal cancer and is closely related to increased cancer cell growth,metastasis,and poor treatment outcomes.Bacterial vaccines cap-able of selectively eliminating bacteria present a promising approach to targeting intratumor F.nuclea-tum,thereby enhancing cancer treatment.Although adjuvants have been employed to enhance the immune response,the vaccine's effectiveness is constrained by inadequate T-cell activation necessary for eradicating intracellular pathogens.In this study,we developed a minimalistic,biomimetic nanovac-cine by integrating highly immunostimulatory adjuvant cholesterol-modified CpG oligonucleotides into the autologously derived F.nucleatum membranes.Compared to the traditional vaccines consisting of inactivated bacteria and Alum adjuvant,the nanovaccine coupled with bacterial membranes and adju-vants could remarkably improve multiple antigens and adjuvant co-delivery to dendritic cells,maximiz-ing their ability to achieve effective antigen presentation and strong downstream immune progress.Notably,the nanovaccine exhibits outstanding selective prophylactic and therapeutic effects,eliminating F.nucleatum without affecting intratumoral and gut microbiota.It significantly enhances chemotherapy efficacy and reduces cancer metastasis in F.nucleatum-infected colorectal cancer.Overall,this work rep-resents the rational application of bacterial nanovaccine and provides a blueprint for future development in enhancing the antitumor effect against bacterial-infected cancer.
      原文链接:
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    Hepatitis B virus core protein as a Rab-GAP suppressor driving liver disease progression

    Yu SuFan BuYuanfei ZhuLe Yang...
    2580-2595页
    查看更多>>摘要：Chronic hepatitis B virus(HBV)infection can lead to advanced liver pathology.Here,we establish a trans-genic murine model expressing a basic core promoter(BCP)-mutated HBV genome.Unlike previous stud-ies on the wild-type virus,the BCP-mutated HBV transgenic mice manifest chronic liver injury that culminates in cirrhosis and tumor development with age.Notably,agonistic anti-Fas treatment induces fulminant hepatitis in these mice even at a negligible dose.As the BCP mutant exhibits a striking increase in HBV core protein(HBc)expression,we posit that HBc is actively involved in hepatocellular injury.Accordingly,HBc interferes with Fis1-stimulated mitochondrial recruitment of Tre-2/Bub2/Cdc16 domain family member 15(TBC1D15).HBc may also inhibit multiple Rab GTPase-activating proteins,including Rab7-specific TBC1D15 and TBC1D5,by binding to their conserved catalytic domain.In cells under mitochondrial stress,HBc thus perturbs mitochondrial dynamics and prevents the recycling of damaged mitochondria.Moreover,sustained HBc expression causes lysosomal consumption via Rab7 hyperactivation,which further hampers late-stage autophagy and substantially increases apoptotic cell death.Finally,we show that adenovirally expressed HBc in a mouse model is directly cytopathic and causes profound liver injury,independent of antigen-specific immune clearance.These findings reveal an unexpected cytopathic role of HBc,making it a pivotal target for HBV-associated liver disease treat-ment.The BCP-mutated HBV transgenic mice also provide a valuable model for understanding chronic hepatitis B progression and for the assessment of therapeutic strategies.
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    Phase Ⅰ clinical trial of intracerebral injection of lentiviral-ABCD1 for the treatment of cerebral adrenoleukodystrophy

    Qiu-Hong WangJing WangZhi-Pei LingZhi-Qiang Cui...
    2596-2603页
    查看更多>>摘要：This was a single-arm,multicenter,open-label phase Ⅰ trial.Lentiviral vectors(LV)carrying the ABCD1 gene(LV-ABCD1)was directly injected into the brain of patients with childhood cerebral adrenoleukodys-trophy(CCALD),and multi-site injection was performed.The injection dose increased from 200 to 1600 μL(vector titer:1 × 109 transduction units per mL(TU/mL)),and the average dose per kilogram body weight ranges from 8 to 63.6 μL/kg.The primary endpoint was safety,dose-exploration and immuno-genicity and the secondary endpoint was initial evaluation of efficacy and the expression of ABCD1 pro-tein.A total of 7 patients participated in this phase Ⅰ study and were followed for 1 year.No injection-related serious adverse event or death occurred.Common adverse events associated with the injection were irritability(71％,5/7)and fever(37.2-38.5 ℃,57％,4/7).Adverse events were mild and self-limited,or resolved within 3 d of symptomatic treatment.The maximal tolerable dose is 1600 μL In 5 cases(83.3％,5/6),no lentivirus associated antibodies were detected.The overall survival at 1-year was 100％.The ABCD1 protein expression was detected in neutrophils,monocytes and lymphocytes.This study suggests that the intracerebral injection of LV-ABCD1 for CCALD is safe and can achieve successful LV transduction in vivo;even the maximal dose did not increase the risk of adverse events.Furthermore,the direct LV-ABCD1 injection displayed low immunogenicity.In addition,the effectiveness of intracere-bral LV-ABCD1 injection has been preliminarily demonstrated while further investigation is needed.This study has been registered in the Chinese Clinical Trial Registry(https://www.chictr.org.cn/,registration number:ChiCTR1900026649).
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    New therapeutic target NCF1-directed multi-bioactive conjugate therapies prevent preterm birth and adverse pregnancy outcomes

    Juan ChengXiaoyan JiaLimei YangSiqi Zhang...
    2604-2621页
    查看更多>>摘要：Preterm birth(PTB)is a leading cause of neonatal morbidity and mortality worldwide,yet the cellular and molecular mechanisms driving this condition remain undeciphered,thus limiting discovery of new ther-apies.In-depth analyses of human and mouse tissues associated with PTB,in combination with cellular studies,indicated that aberrantly high-expressed neutrophil cytoplasmic factor(NCF)1 leads to oxidative distress,recruitment,and pro-inflammatory activation of neutrophils and macrophages,while sequen-tially overexpressed pro-inflammatory mediators induce contractions of uterine smooth muscle cells(USMCs)as well as apoptosis of USMCs and amniotic epithelial cells,thereby causing PTB.According to these new findings,we rationally engineered an amphiphilic macromolecular conjugate LPA by cova-lently integrating low-molecular-weight heparin,a reactive oxygen species-responsive/scavenging com-ponent,and an anti-inflammatory peptide.This bioengineered macromolecular conjugate can self-assemble into multi-bioactive nanoparticles(LPA NP).In a mouse model of PTB,LPA NP effectively delayed PTB and inhibited adverse pregnancy outcomes,by regulating NCF1-mediated oxidative-inflammatory cascades,i.e.,attenuating oxidative stress,inhibiting inflammatory cell activation,reducing local inflammation,and decreasing contraction/apoptosis of myometrial cells.Packaging LPA NP into temperature-responsive,self-healing,and bioadhesive hydrogel further potentiated its in vivo efficacies after intravaginal delivery,by prolonging retention time,sustaining nanotherapy release,and increasing bioavailability in the placenta/uterus.Importantly,both the conjugate/nanotherapy and hydrogel formu-lations exhibited excellent safety profiles in pregnant mice,with negligible side effects on the mother and offspring.
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