首页期刊导航|世界儿科杂志（英文版）
期刊信息/Journal information
世界儿科杂志（英文版）
世界儿科杂志（英文版）

双月刊

世界儿科杂志（英文版）/Journal World Journal of PediatricsCSCDCSTPCD北大核心SCI
正式出版
收录年代

    Current status of Mycoplasma pneumoniae infection in China

    Chao YanGuan-Hua XueHan-Qing ZhaoYan-Ling Feng...
    1-4页
      原文链接:
    • NETL
    • NSTL
    • 万方数据

    Current Mycoplasma pneumoniae epidemic among children in Shanghai:unusual pneumonia caused by usual pathogen

    Xiao-Bo ZhangWen HeYong-Hao GuiQuan Lu...
    5-10页
      原文链接:
    • NETL
    • NSTL
    • 万方数据

    Expert consensus on the diagnosis,treatment,and prevention of respiratory syncytial virus infections in children

    Xian-Li ZhangXi ZhangWang HuaZheng-De Xie...
    11-25页
    查看更多>>摘要：Background Respiratory syncytial virus(RSV)is the leading global cause of respiratory infections and is responsible for about 3 million hospitalizations and more than 100,000 deaths annually in children younger than 5 years,representing a major global healthcare burden.There is a great unmet need for new agents and universal strategies to prevent RSV infections in early life.A multidisciplinary consensus development group comprising experts in epidemiology,infectious diseases,respiratory medicine,and methodology aims to develop the current consensus to address clinical issues of RSV infections in children.Data sources The evidence searches and reviews were conducted using electronic databases,including PubMed,Embase,Web of Science,and the Cochrane Library,using variations in terms for"respiratory syncytial virus","RSV","lower respira-tory tract infection","bronchiolitis","acute","viral pneumonia","neonatal","infant""children",and"pediatric".Results Evidence-based recommendations regarding diagnosis,treatment,and prevention were proposed with a high degree of consensus.Although supportive care remains the cornerstone for the management of RSV infections,new monoclonal antibodies,vaccines,drug therapies,and viral surveillance techniques are being rolled out.Conclusions This consensus,based on international and national scientific evidence,reinforces the current recommenda-tions and integrates the recent advances for optimal care and prevention of RSV infections.Further improvements in the management of RSV infections will require generating the highest quality of evidence through rigorously designed studies that possess little bias and sufficient capacity to identify clinically meaningful end points.
      原文链接:
    • NETL
    • NSTL
    • 万方数据

    A comprehensive review of genetic causes of obesity

    Marcio José Concepción-ZavaletaJuan Eduardo Quiroz-AldaveMaría del Carmen Durand-VásquezElman Rolando Gamarra-Osorio...
    26-39页
    查看更多>>摘要：Background Obesity is a multifactorial chronic disease with a high,increasing worldwide prevalence.Genetic causes account for 7％of the cases in children with extreme obesity.Data sources This narrative review was conducted by searching for papers published in the PubMed/MEDLINE,Embase and SciELO databases and included 161 articles.The search used the following search terms:"obesity","obesity and genetics","leptin","Prader-Willi syndrome",and"melanocortins".The types of studies included were systematic reviews,clinical trials,prospective cohort studies,cross-sectional and prospective studies,narrative reviews,and case reports.Results The leptin-melanocortin pathway is primarily responsible for the regulation of appetite and body weight.However,several important aspects of the pathophysiology of obesity remain unknown.Genetic causes of obesity can be grouped into syndromic,monogenic,and polygenic causes and should be assessed in children with extreme obesity before the age of 5 years,hyperphagia,or a family history of extreme obesity.A microarray study,an analysis of the melanocortin type 4 receptor gene mutations and leptin levels should be performed for this purpose.There are three therapeutic levels:lifestyle modifications,pharmacological treatment,and bariatric surgery.Conclusions Genetic study technologies are in constant development;however,we are still far from having a personalized approach to genetic causes of obesity.A significant proportion of the affected individuals are associated with genetic causes;however,there are still barriers to its approach,as it continues to be underdiagnosed.
      原文链接:
    • NETL
    • NSTL
    • 万方数据

    Is tuberous sclerosis complex-associated autism a preventable and treatable disorder?

    Paolo CuratoloMirte ScheperLeonardo Emberti GialloretiNicola Specchio...
    40-53页
    查看更多>>摘要：Background Tuberous sclerosis complex(TSC)is a genetic disorder caused by inactivating mutations in the TSC1 and TSC2 genes,causing overactivation of the mechanistic(previously referred to as mammalian)target of rapamycin(mTOR)signaling pathway in fetal life.The mTOR pathway plays a crucial role in several brain processes leading to TSC-related epilepsy,intellectual disability,and autism spectrum disorder(ASD).Pre-natal or early post-natal diagnosis of TSC is now possible in a growing number of pre-symptomatic infants.Data sources We searched PubMed for peer-reviewed publications published between January 2010 and April 2023 with the terms"tuberous sclerosis","autism",or"autism spectrum disorder","animal models","preclinical studies","neurobiol-ogy",and"treatment".Results Prospective studies have highlighted that developmental trajectories in TSC infants who were later diagnosed with ASD already show motor,visual and social communication skills in the first year of life delays.Reliable genetic,cellular,electroencephalography and magnetic resonance imaging biomarkers can identify pre-symptomatic TSC infants at high risk for having autism and epilepsy.Conclusions Preventing epilepsy or improving therapy for seizures associated with prompt and tailored treatment strategies for autism in a sensitive developmental time window could have the potential to mitigate autistic symptoms in infants with TSC.
      原文链接:
    • NETL
    • NSTL
    • 万方数据

    Influence of preterm birth on the association between gestational diabetes mellitus and childhood developmental vulnerability:a causal mediation analysis

    Bereket DukoAmanuel Tesfay GebremedhinGizachew Assefa TessemaGavin Pereira...
    54-63页
    查看更多>>摘要：Background Epidemiological studies examining the direct and indirect effects of gestational diabetes mellitus(GDM)on offspring early childhood developmental vulnerability are lacking.Therefore,the aims of this study were to estimate the direct and indirect effects of GDM(through preterm birth)on early childhood developmental vulnerability.Methods We conducted a retrospective population-based cohort study on the association between gestational diabetes mel-litus and early childhood developmental vulnerability in children born in Western Australia(WA)using maternal,infant and birth records from the Midwives Notification,Hospitalizations,Developmental Anomalies,and the Australian Early Development Census(AEDC)databases.We used two aggregated outcome measures:developmentally vulnerable on at least one AEDC domain(DV1)and developmentally vulnerable on at least two AEDC domains(DV2).Causal mediation analysis was applied to estimate the natural direct(NDE),indirect(NIE),and total(TE)effects as relative risks(RR).Results In the whole cohort(n=64,356),approximately 22％were classified as DV1 and 11％as DV2 on AEDC domains.Estimates of the natural direct effect suggested that children exposed to GDM were more likely to be classified as DV1(RR=1.20,95％CI:1.10-1.31)and DV2(RR=1.34,95％CI:1.19-1.50)after adjusting for potential confounders.About 6％and 4％of the effect of GDM on early childhood developmental vulnerability was mediated by preterm birth for DV 1 and DV2,respectively.Conclusion Children exposed to gestational diabetes mellitus were more likely to be developmentally vulnerable in one or more AEDC domains.The biological mechanism for these associations is not well explained by mediation through preterm birth.
      原文链接:
    • NETL
    • NSTL
    • 万方数据

    Delivery room resuscitation intensity and associated neonatal outcomes of 24+0-31+6 weeks'preterm infants in China:a retrospective cross-sectional study

    Si-Lu WangChun ChenXin-Yue GuZhao-Qing Yin...
    64-72页
    查看更多>>摘要：Background The aim of this study was to review current delivery room(DR)resuscitation intensity in Chinese tertiary neonatal intensive care units and to investigate the association between DR resuscitation intensity and short-term outcomes in preterm infants born at 24+0-31+6 weeks'gestation age(GA).Methods This was a retrospective cross-sectional study.The source population was infants born at 24+0-31+6 weeks'GA who were enrolled in the Chinese Neonatal Network 2019 cohort.Eligible infants were categorized into five groups:(1)regular care;(2)oxygen supplementation and/or continuous positive airway pressure(O2/CPAP);(3)mask ventilation;(4)endotracheal intubation;and(5)cardiopulmonary resuscitation(CPR).The association between DR resuscitation and short-term outcomes was evaluated by inverse propensity score-weighted logistic regression.Results Of 7939 infants included in this cohort,2419(30.5％)received regular care,1994(25.1％)received O2/CPAP,1436(18.1％)received mask ventilation,1769(22.3％)received endotracheal intubation,and 321(4.0％)received CPR in the DR.Advanced maternal age and maternal hypertension correlated with a higher need for resuscitation,and antenatal steroid use tended to be associated with a lower need for resuscitation(P＜0.001).Severe brain impairment increased significantly with increasing amounts of resuscitation in DR after adjusting for perinatal factors.Resuscitation strategies vary widely between centers,with over 50％of preterm infants in eight centers requiring higher intensity resuscitation.Conclusions Increased intensity of DR interventions was associated with increased mortality and morbidities in very preterm infants in China.There is wide variation in resuscitative approaches across delivery centers,and ongoing quality improve-ment to standardize resuscitation practices is needed.
      原文链接:
    • NETL
    • NSTL
    • 万方数据

    Neighborhood predictors of short sleep duration and bedtime irregularity among children in the United States:results from the 2019-2020 National Survey of Children's Health

    Ying DaiJianghong Liu
    73-81页
    查看更多>>摘要：Background Environmental factors may contribute to short sleep duration and irregular bedtime in children.Neighborhood factors and children's sleep duration and bedtime regularity remain a less investigated area.The aim of this study was to investigate the national and state-level proportions of children with short sleep duration and irregular bedtime and their neighborhood predictors.Methods A total of 67,598 children whose parents completed the National Survey of Children's Health in 2019-2020 were included in the analysis.Survey-weighted Poisson regression was used to explore the neighborhood predictors of children's short sleep duration and irregular bedtime.Results The prevalence of short sleep duration and irregular bedtime among children in the United States(US)was 34.6％[95％confidence interval(CI)=33.8％-35.4％]and 16.4％(95％CI=15.6％-17.2％)in 2019-2020,respectively.Safe neigh-borhoods,supportive neighborhoods,and neighborhoods with amenities were found to be protective factors against children's short sleep duration,with risk ratios ranging between 0.92 and 0.94,P＜0.05.Neighborhoods with detracting elements were associated with an increased risk of short sleep duration[risk ratio(RR)=1.06,95％CI=1.00-1.12]and irregular bedtime(RR=1.15,95％CI=1.03-1.28).Child race/ethnicity moderated the relationship between neighborhood with amenities and short sleep duration.Conclusions Insufficient sleep duration and irregular bedtime were highly prevalent among US children.A favorable neigh-borhood environment can decrease children's risk of short sleep duration and irregular bedtime.Improving the neighborhood environment has implications for children's sleep health,especially for children from minority racial/ethnic groups.
      原文链接:
    • NETL
    • NSTL
    • 万方数据

    PACS gene family-related neurological diseases:limited genotypes and diverse phenotypes

    Han ZhangKai GaoShuang WangYue-Hua Zhang...
    82-91页
    查看更多>>摘要：Background The PACS gene family has been demonstrated to be related to intracellular vesicular trafficking.The phenotypic manifestations caused by the pathogenic variants of PACS include epilepsy,intellectual disability/developmental delay,and malformations,such as facial abnormalities.Methods We identified seven new cases with pathogenic or likely pathogenic PACS variants using next-generation sequenc-ing.Detailed information obtained from these patients was analyzed along with that obtained from previously reported patients.Results With the inclusion of the newly diagnosed cases in this study,103 cases with PACS gene family-related neurological diseases were reported,of which 43 were PACS2-related cases and the remaining were PACS1-related cases.Most patients had seizures,which have been reported to be effectively controlled by several types of anti-seizure medications(ASMs).The most efficacious and frequently prescribed ASMs included sodium valproate(43.3％,13/30),oxcarbazepine/carbamazepine(26.7％,8/30),and levetiracetam(20％,6/30).Almost all patients had intellectual disability/developmental delay.The most common pathogenic missense variants were PACS1 p.Arg203Trp and PACS2 p.Glu209Lys.In addition,we report a patient carrying a likely pathogenic copy number variation(CNV)(de novo heterozygous deletion of chrl4:105821380-106107443,286 kilobase,destroyed part of the furin-binding region domain and the protein structure after it)with more severe and refractory late-onset epilepsy.Conclusions The clinical phenotypes of the different PACS heterozygous missense variants were similar.The pathogenic variant sites of PACS1 and PACS2 were quite limited but located in different regions.A CNV destroying part of the PACS2 gene might also be pathogenic.These findings may provide an important clue for further functional studies on the pathogenic mechanism of neurological disorders related to the PACS gene family.
      原文链接:
    • NETL
    • NSTL
    • 万方数据

    Coinfection of SARS-CoV-2 Omicron variant and other respiratory pathogens in children

    Wei LiBing-Han WangBao-Hai ChenYi Sun...
    92-96页
      原文链接:
    • NETL
    • NSTL
    • 万方数据