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中华实用儿科临床杂志
中华实用儿科临床杂志

郭学鹏

半月刊

2095-428X

syqk@xxmu.edu.cn

0373-3029144，3831456

453003

河南省新乡市新乡医学院

中华实用儿科临床杂志/Journal Journal of Applied Clinical PediatricsCSCD北大核心CSTPCD
查看更多>>本刊创刊20年来，严格遵守国家的出版法规及条例，执行出版编辑规范，始终坚持突出实用为主，理论联系实践，注重基础与临床相结合，报道儿科领域新的科研成果、新理论、新技术、新进展，为促进我国儿科医学领域的学术交流服务为办刊宗旨。2005年本刊的总被引频次1417，在18种妇、儿科医学类期刊中列第4位，在1606种中国科技论文统计源期刊中列第79位；影响因子0.659，在18种妇、儿科医学类期刊中列第6位，在1606种中国科技论文统计源期刊中列第221位；即年指标0.155,在8种儿科学类期刊中仅次于《中华儿科杂志》，位居第2位，其他学术期刊指标均较去年明显提高。目前已连续四次进入北京大学图书馆主编的《中文核心期刊要目总览》、列入中国科技论文统计源期刊（中国科技核心期刊），2003年被俄罗斯《文摘杂志》收录,2005年又被美国《化学文摘》收录。2004年被评为河南省优秀期刊。我刊已被中国生物医学文献数据库（CBMdisc）、Quick全文资料管理系统（FTME）、中文科技期刊数据库、中国学术期刊（光盘版）、万方数据库和美国《化学文摘》、俄罗斯《文摘杂志》、《中国医学文摘：儿科学分册》等多种权威性数据库与文摘期刊作为固定收录对象。
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收录年代

    新生儿纵隔及椎管内卡波西型血管内皮瘤伴卡梅现象1例

    李婷陈振杰张晨美单卫华...
    221-223页
    查看更多>>摘要：回顾性分析浙江大学医学院附属儿童医院2022年10月确诊的1例纵隔及椎管内卡波西型血管内皮瘤(KHE)患儿的临床资料，并对纵隔KHE进行文献复习，总结其临床特征及治疗情况。患儿，男，25 d，以难治性血小板减少为主要表现，多次胸片示纵隔显著增宽，左上肺不典型肺不张表现，经胸部增强CT及磁共振成像诊断为纵隔及椎管内KHE。治疗上采用鸡尾酒疗法(糖皮质激素＋长春新碱＋西罗莫司)后血小板升至正常，凝血功能改善。目前随访3个月，血液参数稳定，肿块缩小，无药物不良反应。 Clinical data of one patient diagnosed with kaposiform hemangioendothelioma (KHE) in the spinal canal and mediastinum at the Children′s Hospital， Zhejiang University School of Medicine in October 2022 were retrospectively analyzed。Additionally， a literature review on mediastinal KHE was performed to summarize prior clinical characteristics and treatments。The patient， a 25-day-old boy， presented with refractory thrombocytopenia。Multiple chest radiographs suggested significant widening of the mediastinum and atypical atelectasis in the left upper lung， and enhanced chest CT and magnetic resonance imaging suggested KHE。After cocktail therapy with Prednisolone， Vincristine and Sirolimus， platelets increased to normal， and coagulation function improved。After 3 months of follow-up， hematologic parameters were stable， the mass became smaller， and no side effects occurred。

    血管内皮瘤,卡波西型卡梅现象纵隔椎管婴儿,新生

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    儿童呼吸道病毒脓毒症的诊治进展

    薛茹王婷严永东范艳芬...
    224-227页
    查看更多>>摘要：脓毒症的本质是宿主对感染性因素的反应失调而引起的器官功能障碍综合征，其发病率及死亡率居高不下，严重威胁儿童的健康和生命。随着2019年新型冠状病毒的暴发流行，病毒性脓毒症，尤其是呼吸道病毒脓毒症引起广泛关注。尽早确立诊断并及时干预对改善预后大有裨益。因此，现主要围绕儿童呼吸道病毒脓毒症的流行病学、病理生理、诊断及治疗方案进行综述，为临床提供参考。 Sepsis， whose morbidity and mortality remain high in children， is a life-threatening organ dysfunction resulting from dysregulated host responses to infection。With the global outbreak of Corona Virus Disease 2019， viral sepsis， especially respiratory viral sepsis， has attracted much attention。Early diagnosis and timely intervention are of great benefit to improve the prognosis of patients。This review focuses on the epidemiology， pathophysiology， diagnosis， and treatment of respiratory viral sepsis in children to provide clinical reference。

    儿童脓毒症呼吸道病毒病理生理诊断治疗

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    白细胞介素10信号通路缺陷引起极早发型炎症性肠病发病机制及治疗的研究进展

    吴天昊张姮方拥军单卫华...
    228-231页
    查看更多>>摘要：儿童极早发型炎症性肠病(VEO-IBD)是指发病年龄<6岁，以反复结肠炎、肛周病变及营养吸收障碍为主要临床表现的炎症性肠病(IBD)。不同于成人，单一基因突变在VEO-IBD发病中起重要作用。迄今为止，已发现约70种单基因缺陷参与VEO-IBD的发病机制，包括上皮屏障、中性粒细胞和吞噬细胞的功能、免疫细胞的选择和激活、免疫抑制机制或凋亡。白细胞介素10(IL-10)是一种抗炎细胞因子，参与调节先天性和适应性免疫，影响促炎分子的表达和多种免疫细胞的功能，在IBD的发生与发展进程中发挥重要作用，大多数IL-10信号通路缺陷(IL-10或IL-10受体缺陷)的患者会在儿童时期就表现出威胁生命的结肠炎。现就IL-10信号通路缺陷引起VEO－IBD的发病机制和治疗方式的研究进展进行综述。 Very early onset inflammatory bowel disease (VEO-IBD) in children refers to an IBD with the onset age of less than 6 years old， clinically characterized by recurrent colitis， perianal lesions， and nutrient absorption disorders。Different from adults， single gene mutation plays an important role in the pathogenesis of VEO-IBD。To date， about 70 single gene defects have been identified involving the pathogenesis of VEO-IBD， including epithelial barrier， neutrophil and phagocyte function， immune cell selection and activation， immunosuppressive mechanism， or apoptosis。Interleukin-10 (IL-10) is an anti-inflammatory cytokine that regulates innate and adaptive immunity， influences the expression of pro-inflammatory molecules and the function of multiple immune cells， and plays a vital role in the development and progression of IBD。Patients with defects in the IL-10 signaling pathway (IL-10 or IL-10 receptor deficiency) may develop life-threatening colitis as early as childhood。This article reviews the progress in the pathogenesis and treatment of VEO-IBD caused by IL-10 signaling pathway defects。

    白细胞介素10极早发型炎症性肠病单基因疾病免疫治疗

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    IgA肾病肠道黏膜免疫致病机制的再认识：肠源性IgA ＋浆细胞

    周楠刘曼臧赫
    232-235页
    查看更多>>摘要：肠源性IgA＋浆细胞是肠道黏膜免疫发挥免疫效应的关键。肠源性IgA＋浆细胞的产生受肠道菌群和饮食调控，不仅在肠道黏膜局部发挥免疫作用，还可迁徙至肠道外的组织或器官，通过依赖产生IgA抗体或分泌细胞因子等非抗体产生效应来调节免疫和炎症反应，在多种疾病中发挥免疫调节的保护或者致病效应。肠道黏膜免疫失衡在IgA肾病中的致病效应逐渐被关注。IgA肾病高血清IgA小鼠肠道固有层IgA＋浆细胞的增多与循环中异常糖基化IgA1增多有关。IgA肾病患者循环中的长寿命浆细胞数量增加，并抑制白细胞介素-6发挥致病作用。但肠源性IgA＋浆细胞是否迁移至肾脏局部促进疾病进展尚不清楚。现就肠源性IgA＋浆细胞在IgA肾病肠道黏膜免疫致病效应及机制的相关研究进展进行综述。 Gut-derived IgA+ plasma cells are the key to intestinal mucosal immunity。The intestinal flora and diet regulate the production of gut-derived IgA+ plasma cells， which not only play an immune role in the intestinal mucosa， but also migrate to tissues or organs outside the intestine to regulate immune and inflammatory reactions by relying on the production of IgA antibodies or the secretion of cytokines and other non-antibody effects， and act as a protective or pathogenic factor in various diseases。The pathogenic effect of intestinal mucosal immune imbalance in IgA nephropathy (IgAN) has been a concern。IgA+ plasma cells increase in intestinal lamina propria of high serum IgA mice with the increase of abnormally glycosylated IgA1。The long-lived plasma cells increase， and interleukin-6 is inhibited in IgAN patients。However， it remains unclear whether gut-derived IgA+ plasma cells migrate to kidneys to promote disease progression。This article reviews the relevant research progress on the immunopathologic effects and mechanisms of gut-derived IgA+ plasma cells in the intestinal mucosa of IgAN。

    IgA肾病黏膜免疫抗体分泌细胞免疫球蛋白A浆细胞

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    儿童青少年睡眠障碍的物理治疗研究进展

    傅燕虹张文柳覃荣山秦岭...
    235-240页
    查看更多>>摘要：睡眠障碍在儿童青少年中非常普遍，在患有神经发育障碍、精神心理疾病等特殊人群中患病率更高，这对儿童青少年睡眠障碍的治疗提出了挑战。儿童青少年睡眠障碍的治疗方法主要包括认知行为治疗、手术治疗、药物治疗及物理治疗。传统的认知行为治疗费用高、合格的睡眠医师及治疗师数量少、患者依从性低。药物治疗虽然是儿童青少年失眠最常用的治疗方法，但缺少适应证和安全性数据的支持，不良反应多，长期疗效未知。通过磁、电、声、光等物理刺激改变中枢和外周神经活性的物理治疗技术可能为无法获得常规治疗、耐受性差或无效的睡眠障碍个体提供有价值的替代治疗选择或补充治疗方案。现就经颅磁刺激、经颅直流电刺激、光照疗法和高压氧治疗4种临床常见的物理治疗及其在儿童青少年睡眠障碍中的应用进展进行综述，为今后儿童青少年睡眠障碍临床治疗提供科学依据和新思路。 Sleep disorders are common in children and adolescents， especially in those with neurodevelopmental and mental disorders， but treatment strategies remain limited。The main therapeutic methods for sleep disorders in children and adolescents include cognitive behavioral therapy， surgical therapy， drug therapy， and physical therapy。Conventional cognitive behavioral therapy is expensive plus， the number of qualified sleep physicians and therapists is limited， and patient′s compliance is low。Drug therapy is the most commonly used treatment for insomnia in children and adolescents， but it lacks evidence-based indications and safety and has many adverse reactions， and its long-term efficacy is unknown。Physical therapy that changes the activity of central and peripheral nerves through physical stimulation such as magnetism， electricity， sound and light can provide valuable alternative or complementary treatment for individuals with sleep disorders who can′t get conventional treatment， have poor tolerance or are ineffective。In this paper， 4 common clinical physical therapies (transcranial magnetic stimulation， transcranial direct current stimulation， light therapy， and hyperbaric oxygen therapy) and their application in treating sleep disorders in children and adolescents are reviewed， providing scientific basis and new ideas for the future clinical treatment of sleep disorders in children and adolescents。

    儿童青少年睡眠睡眠障碍经颅磁刺激经颅直流电刺激光照疗法高压氧治疗

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