查看更多>>摘要:目的 观察益肾健脾活血方穴位敷贴联合健身气功五禽戏对改善透析治疗的衰弱患者机体的营养状况及衰弱程度的效果及影响,为透析患者衰弱的康复治疗提供依据。 方法 采用随机对照研究方法,便利抽样法选取南京中医药大学附属医院肾内科2020年4月至2021年12月住院规律透析治疗的衰弱患者80例,按照随机数字表法分为对照组与试验组各40例。对照组采用规律透析、基础治疗及饮食护理,试验组在此基础上采用健脾益肾活血方穴位敷贴联合健身气功五禽戏。比较2组患者干预前、干预12周后实验室检查结果、主观整体评估量表得分及中医症状得分;比较2组患者干预前及干预4、8、12周后不同时间点的Fried衰弱量表得分变化。 结果 对照组年龄(54.08 ± 11.34)岁,男23例,女17例。试验组年龄(57.38 ± 9.89)岁,男19例,女21例。干预4、8、12周后不同时间点试验组的Fried衰弱量表得分分别为2(2,2)、1(1,2)、1(0,1)分,低于对照组的3(2,4)、2(2,3)、2(2,3)分,其时间效应、组间效应及交互效应的比较,差异均有统计学意义(F=105.76、18.38、46.67,均P<0.01),组内进一步两两比较发现,干预后不同时间点2组Fried衰弱量表得分的比较,差异均有统计学意义(Z=-2.78、-4.01、-6.08,均P<0.01)。试验组干预12周后血红蛋白、血清白蛋白、血清前白蛋白检验结果分别为(107.88 ± 15.58)g/L、(39.10 ± 4.92)g/L、(289.36 ± 72.05)mg/L,高于对照组的(100.15 ± 17.62)g/L、(36.93 ± 4.72)g/L、(255.63 ± 75.35)mg/L,差异均有统计学意义(t=-2.08、-2.01、-2.05,均P<0.05)。干预12周后试验组主观整体评估量表A级(营养良好)及B级(轻中度营养不良)例数分别为36、4例,对照组分别为23、17例,2组比较差异有统计学意义(χ2=10.91,P<0.01)。干预12周后试验组中医症状得分为(4.68 ± 2.50)分,低于对照组的(9.58 ± 4.40)分,差异有统计学意义(t=6.13,P<0.01)。 结论 益肾健脾活血方穴位敷贴联合健身气功五禽戏可有效改善透析衰弱患者的营养状况,减轻患者的衰弱程度。 Objective To observe the effect of point application-invigorate the spleen and kidney, circulation of blood formula (PA) combined with five-animal exercise (FAE) on improving the nutritional status for asthenia of patients with dialysis, and provide evidence for the rehabilitation treatment of dialysis patients. Methods According to the random number table method, a total of 80 patients treated with regular dialysis at Department of Nephrology, the Affiliated Hospital of Nanjing University of Chinese Medicine from April 2020 to December 2021 were randomly divided into experimental group and control group, with 40 cases in each group. Participants in the control group received regular dialysis, basic treatment and diet nursing (RBD). Participants in the experimental group received RBD plus PA+FAE. Labaratory test results, Subjective Global Assessment scale score and Traditional Chinese medicine symptom score were measured at baseline and 12-weeks after the intervention. The Fried Frailty scale score was measured at baseline, 4, 8, and 12 weeks after the intervention. Results The control group aged (54.08 ± 11.34) years old, 23 males, 17 females the experimental group aged (57.38±9.89) years old, 19 males, 21 females. After 4, 8 and 12 weeks of intervention, the Fried Frailty Scale scores of the experimental group at different time points were 2 (2, 2), 1 (1, 2) and 1 (0, 1), respectively, lower than 3 (2, 4), 2 (2, 3) and 2 (2, 3) of the control group, and the differences in time effect, inter-group effect and interaction effect were statistically significant (F=105.76, 18.38, 46.67, all P<0.01). Further pairwise comparisons within groups indicated significant differences of Fried Frailty scale scores at different time points (Z=-2.78, -4.01, -6.08, all P<0.01). After 12-week of intervention, the results of hemoglobin, serum albumin and serum prealbumin were (107.88 ± 15.58) g/L, (39.10 ± 4.92) g/L, and (289.36 ± 72.05) mg/L in the experimental group, respectively, higher than (100.15 ± 17.62) g/L, (36.93 ± 4.72) g/L, (255.63 ± 75.35) mg/L in the control group (t=-2.08, -2.01, -2.05, all P<0.05). Subjective Overall Assessment scale was found a significant difference between the 2 groups (χ2=10.91, P<0.01): the number of grade A (good nutrition) and B (mild to moderate malnutrition) were 36 and 4 in the experimental group and 23 and 17 in the control group. Traditional Chinese medicine symptom score was (4.68 ± 2.50) in the experimental group, lower than (9.58 ± 4.40) in the control group (t=6.13, P<0.01). Conclusions Point application-invigorate the spleen and kidney and circulation of blood formula combined with five-animal exercise can effectively improve the nutritional status of dialysis patients and reduce the weakness of patients