查看更多>>摘要:目的 探讨在健康教育的基础上,不同频率的血糖监测对超重/肥胖的糖尿病前期人群血糖控制的有效性,为糖尿病前期人群血糖监测管理提供依据。 方法 以随机对照研究,按连续抽样法选取2021年1—3月中国医科大学附属第一医院体检中心、内分泌门诊、内分泌病房的糖尿病前期人群90例,采用抽签法随机分为A、B、C 3组,每组各30例,研究周期为12个月。A、B、C 3组均在入组时、6个月随访和12个月随访进行统一的健康教育指导。A组每6个月进行1次血糖监测,B组每3个月进行1次血糖监测,C组每个月进行1次血糖监测。记录并比较3组参与者入组时、6个月随访时及12个月随访时的糖化血红蛋白水平(HbA1c)、空腹血糖、糖负荷后2 h血糖(2 hPG)及BMI水平。 结果 A组男15例,女15例;B组男14例,女16例;C组男12例,女18例。A、B、C 3组的年龄分别为(48.37 ± 10.80)、(49.20 ± 9.75)、(44.77 ± 12.28)岁。随访12个月时,A、B、C 3组的HbA1c分别为(6.01 ± 0.36)%、(5.82 ± 0.35)%、(5.64 ± 0.27)%,3组比较差异有统计学意义(F=9.72,P<0.05);空腹血糖分别为(5.64 ± 0.88)、(5.05 ± 0.53)、(4.98 ± 0.48)mmol/L,3组比较差异有统计学意义(F=9.23,P<0.05);2 hPG分别为(9.38 ± 1.23)、(8.23 ± 0.72)、(7.71 ± 0.86)mmol/L,3组比较差异有统计学意义(F=23.89,P<0.05);BMI分别为(28.52 ± 4.24)、(27.02 ± 2.67)、(25.56 ± 1.34)kg/m2,差异有统计学意义(F=7.37,P<0.05)。 结论 在健康教育的基础上,与常规每6个月进行1次血糖监测相比,每3个月进行1次血糖监测和每个月进行1次血糖监测,能够改善超重/肥胖的中青年糖尿病前期人群的血糖和BMI水平,为在临床实践中寻求有效、经济的血糖监测模式提供依据。 Objective To explore the effectiveness of blood glucose monitoring at different frequencies on the control of blood glucose in overweight/obese prediabetes population on the basis of health education, and to provide a basis for blood glucose monitoring and management in prediabetes population. Methods A randomized controlled study was used. 90 prediabetes patients from the Physical Examination Center/Endocrine Clinic/Endocrine Ward of the First Affiliated Hospital of China Medical University from January to March 2021 were selected by continuous sampling method, and were randomly divided into the group A, B and C by lottery method, with 30 patients in each group, and the study period was 12 months. Group A, B and C received unified health education guidance at enrollment, 6-month follow-up, and 12-month follow-up. Group A underwent blood glucose monitoring every 6 months, group B underwent blood glucose monitoring every 3 months, group C underwent blood glucose monitoring every month. Recorded and compared the levels of glycated hemoglobin (HbA1c), fasting plasma glucose (FPG), 2-hour post-load blood glucose (2 hPG), and body mass index (BMI) of three groups at the time points of enrollment, 6-month follow-up, and 12-month follow-up. Results There were 15 males and 15 females in the group A, 14 males and 16 females in the group B, 12 males and 18 females in the group C. The ages in the group A, B and C were (48.37 ± 10.80), (49.20 ± 9.25) and (44.77 ± 12.28) years old respectively. At the time point of 12-month follow-up, the HbA1c in the group A, B and C were (6.01 ± 0.36)%, (5.82 ± 0.35)% and (5.64 ± 0.27)%, the difference was significant (F=9.72, P<0.05) the FPG in the group A, B and C were (5.64 ± 0.88), (5.05 ± 0.53) and (4.98 ± 0.48)mmol/L, the difference was significant (F=9.23, P<0.05) the 2 hPG in the group A, B and C were (9.38 ± 1.23), (8.23 ± 0.72) and (7.71 ± 0.86) mmol/L, the difference was significant (F=23.89, P<0.05) the BMI in the group A, B and C were (28.52 ± 4.24), (27.02 ± 2.67) and (25.56 ± 1.34) kg/m2, the difference was significant (F=7.37, P<0.05). Conclusions On the basis of health education, compared with the routine blood glucose monitoring once every six months, blood glucose monitoring once every three months and once every month can improve the blood glucose control and BMI level of overweight/obese young and middle-aged people with prediabetes, and provide a basis for seeking an effective and economic blood glucose monitoring mode in clinical practice.