首页期刊导航|中医科学杂志（英文）
期刊信息/Journal information
中医科学杂志（英文）
北京中医药大学、清华大学出版社有限公司
中医科学杂志（英文）

北京中医药大学、清华大学出版社有限公司

季刊

2095-7548

bucmjtcms@163.ccom

010-64286200

100029

北京市朝阳区北三环东路11号

中医科学杂志（英文）/Journal Journal of Traditional Chinese Medical Sciences
查看更多>>《中医科学杂志（英文）》是中医药领域的同行评审杂志，创刊于2014年7月，由教育部主管，北京中医药大学和清华大学出版社联合主办，国际出版集团Elsevier负责在线出版和开放获取,北京中医药大学校长徐安龙教授担任主编。本杂志致力于搭建最具权威性的英文平台，向国际输出最前沿、最严谨的中医药研究成果，传播各国中医药政策及相关产业发展的信息，反映当今世界中医药研究最高水准。杂志主要收录原创研究类文章，内容覆盖中医、中药、针灸领域，包括各种基础和临床研究，以及综述、政策新闻和病例报告。
正式出版
收录年代

    Zhang Jiebin-Master of the School of Tonifying with Medicinals Warm in Nature

    Yongxuan LiangYinghua Huang
    387-388页
      原文链接:
    • 国家科技期刊平台
    • NETL
    • NSTL
    • 万方数据

    New understanding of using"heart adjusting acupuncture method"to prevent and treat atherosclerotic cardiovascular disease

    Yu GaoGuanhu YangChao An
    389-394页
    查看更多>>摘要：This article explores the foundational research,Chinese medicine theories,and clinical applications of the"heart adjusting acupuncture method"developed by Professor Guanhu Yang to prevent and treat athero-sclerotic cardiovascular disease(ASCVD).Professor Yang established this method based on experimental studies involving electroacupuncture along the horizontal umbilical line,which demonstrated a reduction in infarct area in the myocardial infarction mice model.This method was formulated using acupoints on the horizontal umbilical line:Daimai(GB 26),Tianshu(ST 25),and Daheng(SP15).Clinical application has shown that it could effectively improve cardiac function and manage various cardiovascular conditions and proposed a new hypothesis for the treatment of myocardial infarction.Further research is required to determine if electroacupuncture stimulation at the site of myocardial infarction or during transportation can extend the critical treatment window,preserve myocardial tissue,and enhance reperfusion therapy prognosis.Professor Yang advocates that,when combined with active Western medicine treatments,the"heart adjusting acupuncture method"offers an effective measure to prevent and treat ASCVD.
      原文链接:
    • 国家科技期刊平台
    • NETL
    • NSTL
    • 万方数据

    Effects of Tai Chi and Qigong on health indicators in people with lumbar disc herniation:A systematic review and meta-analysis

    Anni ZhaoJunru MaoYiqing CaiMi'na Wang...
    395-404页
    查看更多>>摘要：Objective:To evaluate the effect of Tai Chi and Qigong on patients with lumbar disc herniation(LDH).Methods:Relevant data were retrieved from nine English and Chinese databases,including Cochrane Library,PubMed,and Wanfang Data,etc.from inception to June 2024.All published randomized controlled trials assessing the effect of Tai Chi and Qigong on visual analog scale(VAS),Japanese Or-thopedic Association(JOA)score,and other health indicators in participants with LDH compared to usual medical care or other treatments were included.Grey literature,trials involving the pushing of hands(Tui Shou)or Tai Chi with weapons,and trials with co-interventions(Tai Chi/Qigong plus another treatment)were excluded.Methodological quality was analyzed using the Cochrane risk of bias tool,and evidence quality was assessed using the Grading of Recommendations,Assessment,Development,and Evaluations(GRADE)tool.Results:Fourteen trials(954 patients)were included in this study.Tai Chi and Qigong were associated with lower VAS pain scores(standardized mean difference-0.55,95％confidence interval[CI]-0.95 to-0.15,P=.01),higher JOA scores(mean difference[MD]4.40,95％CI 2.62 to 6.18,P＜.001)and straight leg raise test results(MD 9.40°,95％CI 7.64 to 11.15,P＜.001)in patients with LDH.Furthermore,compared with usual care,Tai Chi and Qigong showed enhanced effects on pain and JOA scores.When compared to other exercises or massage,the effect on pain scores was similar but that on JOA scores was significant.Conclusions:Tai Chi and Qigong may have favorable effects on VAS pain and JOA scores compared with usual care,and on JOA scores compared with other exercises or massage in patients with LDH.Given the overall poor quality of the evidence,the results of current study should be interpreted cautiously.
      原文链接:
    • 国家科技期刊平台
    • NETL
    • NSTL
    • 万方数据

    Efficacy and mechanism of Xiaoshuan enteric-coated capsule as an adjunctive treatment for ischemic stroke:A randomized clinical trial

    Chunli WenZhixia SuZhibin DingCungen Ma...
    405-414页
    查看更多>>摘要：Objective:To explore the clinical efficacy of Xiaoshuan enteric-coated capsule(XSECC)in treating ce-rebral infarction and its potential mechanism of action.Methods:Patients with acute ischemic stroke(AIS)of the qi deficiency and blood stasis type were randomly assigned to the control and observation groups.They were evaluated using the National In-stitutes of Health Stroke Scale(N1HSS),Activities of Daily Living(ADL),Hachinskilnchemic Scale(HIS),Barthel Index(BI),clinical efficacy scores,and TCM syndrome scores on days 0,14,30,and 90.Furthermore,VEGF and BDNF levels were measured on days 30 and 90.Finally,we analyzed the changes in each scale score and vascular neurological factor in both groups.Results:After 14 days of treatment,the difference values in NIHSS,ADL,and BI were higher,and TCM syndrome and clinical efficacy scores were increased in the observation group compared with those of the control group(all P＜.05).After 30 days,the NIHSS,ADL,HIS,and TCM syndrome scores were decreased compared with those of the control group,while BI and clinical efficacy scores were increased(all P＜.05).After 90 days,the difference value in ADL was higher,and TCM syndrome score was increased in the observation group compared with that of the control group(P=.047,P=.005,respectively).The levels of VEGF and BDNF were higher in the observation group than in the control group on days 14,30,and 90(all P＜.05).VEGF and BDNF levels on day 0 were associated with prognosis of patients with AIS;therefore,they have a predictive value for the prognosis of acute cerebral infarction.Conclusions:XSECC therapy can improve clinical outcomes in patients with acute and recurrent cerebral infarctions.Its mechanism of action may be associated with the secretion of VEGF and BDNF.
      原文链接:
    • 国家科技期刊平台
    • NETL
    • NSTL
    • 万方数据

    Efficacy and safety of Liqingtong granules in the treatment of hyperuricemia:A randomized double-blind placebo-controlled pilot clinical trial

    Jinlian LiuYi YangMeiyu LvWenting Fei...
    415-422页
    查看更多>>摘要：Objective:To investigate the efficacy and safety of Liqingtong(LQT)granules in patients with dampness-heat hyperuricemia.Methods:A randomized,double-blind,placebo-controlled pilot trial was conducted at the 983rd Hos-pital of the Joint Logistic Support Force of the People's Liberation Army from March 15,2023,to August 10,2023.In total,119 participants were enrolled in this trial,and participants were given either LQT granules or placebo for 60 days based on a health education.The primary outcome was serum uric acid(SUA)level,and the secondary outcome was the traditional Chinese medicine(TCM)symptom score,measured on days 0,30,and 60.Safety indicators,including liver function,kidney function,blood routine,glucose,blood lipid,blood pressure,and heart rate were tested on days 0 and 60 of the trial.The data were analyzed using Prism 9 software,and the significance level was set at P＜.05.Results:Among 119 participants,six in the LQT granule group and seven in the placebo group dropped out,and 106 participants completed clinical observation.Baseline information,including SUA levels,TCM symptom scores,and other clinical characteristics,did not differ between the groups.At the end of the trial,compared with baseline values,the SUA levels in the LQT granule group decreased(P＜.001),and no significant change was observed in the placebo group(P=.422);compared with the placebo group,the SUA levels decreased in the LQT granule group(P=.001).Compared with baseline values,the total TCM symptom scores in the LQT granule group decreased(P＜.001),with no change in the placebo group(P=.136).Safety indicators did not differ significantly between the two groups.Conclusion:The pilot trial demonstrated the potential of LQT granules to lower SUA levels and improve symptoms of dampness and heat.
      原文链接:
    • 国家科技期刊平台
    • NETL
    • NSTL
    • 万方数据

    Treatment of active ulcerative colitis with Yinmei Kuijie decoction combined with 5-aminosalicylic acid:A non-randomized multicenter prospective observational protocol based on real-world conditions

    Xinyu ZhangYuan LiPing LiYunze Liu...
    423-427页
    查看更多>>摘要：Objective:To determine the efficacy and safety of the Yinmei Kuijie decoction combined with 5-ami-nosalicylic acid(5-ASA)in treating mildly to moderately active ulcerative colitis(UC)under real-world conditions.Methods:This multicenter,prospective,non-randomized,observational study will be conducted in real-world settings.A total of 204 eligible patients will be consecutively enrolled in the study.Patients in the combination treatment group will receive Yinmei Kuijie decoction in combination with 5-ASA,whereas those in the control group will be treated with 5-ASA alone.The primary endpoint will be a clinical response at week 12,defined as a ≥3 point and ≥30％reduction from baseline in the Mayo total score with ≥1 reduction in rectal bleeding or rectal bleeding score=0 or 1.Secondary efficacy endpoints at week 12 will include health-related quality of life,mucosal healing,and inflammation indicators.Conclusion:The results of this study may provide evidence of the efficacy and safety of Yinmei Kuijie decoction combined with 5-ASA in treating patients with mildly to moderately active UC under real-world principles.The results will provide a basis for further confirmatory studies on the efficacy of Yinmei Kuijie decoction.
      原文链接:
    • 国家科技期刊平台
    • NETL
    • NSTL
    • 万方数据

    Acupuncture for overactive bladder in adults:Study protocol for a randomized controlled trial

    Fengqin CaoDiyuan MaYueying ChenQiongqiong Liu...
    428-434页
    查看更多>>摘要：Background:Overactive bladder(OAB)is a prevalent condition that substantially degrades patient quality of life.Acupuncture is recognized as an effective therapeutic approach for various urological diseases.However,there is limited evidence validating the effectiveness and safety of acupuncture for OABs.Objective:To assess the therapeutic efficacy of acupuncture for OAB and to investigate the potential mechanisms by analyzing its effects on relevant urinary biomarkers.Methods:This is a randomized,participants and outcome assessors blinded,sham acupuncture controlled trial.A total of 110 patients with OABs will be randomly divided in a 1∶1 ratio between the acupuncture and sham acupuncture groups.Participants in the acupuncture group will undergo 30-min authentic acupuncture,while their counterparts in the sham acupuncture group will undergo sham acupuncture needling non-acupoints superficially three times weekly for a duration of 8 weeks.The two co-primary outcomes will be the change in the mean number of micturitions per 24 h from baseline to the end of the 8-week treatment and 20-week follow-up.The secondary outcomes will encompass the change in Overactive Bladder Symptom Score,Overactive Bladder Questionnaire Short Form,and average 24 h values of urgency,daytime micturition,nocturia,and mean volume voided per micturition from baseline to weeks 8 and 20.Urinary nerve growth factor,brain-derived neurotrophic factor,and monocyte chemoattractant protein-1 levels will be measured at baseline and week 8.Adverse events will also be documented.Discussion:The results of this trial will provide evidence for the effectiveness and safety of acupuncture in the management of OAB.
      原文链接:
    • 国家科技期刊平台
    • NETL
    • NSTL
    • 万方数据

    TCM practitioners'attitudes and perceptions regarding the use of Ephedra sinica Stapf:An observational study

    Aiwen ChangXiaopeng ZhaoLin ZhangSijia Zhao...
    435-442页
    查看更多>>摘要：Objective:To understand the attitudes and perceptions of traditional Chinese medicine(TCM)practitioners in Beijing TCM hospitals regarding the use of Ephedra sinica Stapf(E.sinica,Ma Huang).Methods:A two-stage cross-sectional study was conducted using a questionnaire survey of TCM practi-tioners in Beijing TCM hospitals between April 2023 and March 2024.The questionnaire included de-mographic information,the clinical background of TCM practitioners,and the clinical application of E.sinica.Logistic regression analysis was used to analyze the relevant influencing factors when using E.sinica.Results:Of the 465 questionnaires collected,441 were valid.Among these,84.81％(374/441)reported having used E.sinica in clinical practice at least once.The commonly used doses of E.sinica-excluding the pediatric department-were 10 g for high doses,6 g for medium,and 3 g for low.The three most frequently used formulas for E.sinica included Maxing Shigan decoction,Mahuang decoction,and Xiao Qing Long decoction.The most common TCM patterns treated with a high dose of E.sinica were wind-cold exterior pattern,wind-cold invading the lung,and wind and water combat with meridians con-gealed by cold.The top three Western medical diagnoses when using E.sinica for treatment were common cold,pneumonia,and upper respiratory tract infections.Nearly half of the respondents reported experiencing adverse reactions from the oral administration of E.sinica,with the most common being palpitations,insomnia,and restlessness.Starting with a low dose and gradually increasing it as appro-priate was identified as an effective approach.Conclusion:This study investigated the attitudes and perceptions of TCM practitioners in Beijing TCM hospitals regarding the dose-efficacy-adverse reaction relationship of E.sinica,providing a reference for the safe and effective clinical use of E.sinica.
      原文链接:
    • 国家科技期刊平台
    • NETL
    • NSTL
    • 万方数据

    Huatan Qushi formula alleviates non-alcoholic fatty liver disease via PI3K/Akt signaling and gut microbiota modulation

    Xiuping ZhangLinghui ZhuJinchen MaYi Zheng...
    443-455页
    查看更多>>摘要：Objective:To provide the mechanism-based pharmacotherapy of the Huatan Qushi formula(HTQS for-mula),for the health management and treatment of non-alcoholic fatty liver disease(NAFLD).Methods:A rat model of NAFLD was employed to examine the efficacy and safety of the HTQS formula.In vivo active components and potential mechanisms of the HTQS formula were identified using UPLC-MS/MS combined with network pharmacology.The influence of the HTQS formula on the dominating proteins in PI3K/Akt pathway was validated in vivo using western blot.Finally,16S rRNA sequencing of the gut microbiome was conducted followed by targeted metabolomics detecting fecal short-chain fatty acids(SCFAs)and bile acids to determine the impact of the HTQS formula on gut microbiota.Results:The HTQS formula reduced weight gain and hepatic steatosis in NAFLD rats and decreased serum total cholesterol(TC),triglycerides,blood glucose,and insulin resistance(IR)without causing liver or kidney injury.We detected 28 components using UPLC-MS/MS and identified 439 shared targets be-tween NAFLD and the HTQS formula.Primarily,we focused on the PI3K/Akt signaling pathway based on protein-protein interaction network analysis.We validated that the HTQS formula inhibited liver stea-tosis and inflammation by increasing the phosphorylation levels of PI3K,AKT,P27,GSK3β in the PI3K/Akt signaling pathway.16S rRNA sequencing revealed that the HTQS formula reduced the abundance of the genus Family_ⅩⅢ_AD3011_group,which was positively correlated with IR and taurodeoxycholic acid.In addition,Lachnospiraceae_UCG_010 inversely correlated with TC and five bile acids,which could be essential to the therapeutic effect of the HTQS formula against NAFLD.Conclusions:The HTQS formula proved to be an effective pharmacotherapy for NAFLD without causing liver or kidney injury.Multiple potent components of the HTQS formula could alleviate liver steatosis and lipid metabolism disorder by modulating the PI3K/Akt signaling pathway and restoring gut microbiota composition.
      原文链接:
    • 国家科技期刊平台
    • NETL
    • NSTL
    • 万方数据

    Buyang Huanwu decoction promotes angiogenesis and improves hemorheological parameters after cervical spinal cord injury

    Luchun XuYongdong YangGuozheng JiangYushan Gao...
    456-465页
    查看更多>>摘要：Objective:To explore the effects of Buyang Huanwu decoction(BYHWD)on vascular neogenesis and hemorheological parameters following cervical spinal cord injury(SCI).Methods:An acute cervical SCI model was established using 84 female Sprague-Dawley rats.Functional recovery of the rats was evaluated using the forelimb locomotor scale score,forelimb grip strength test,and Basso-Beattie-Bresnahan score.The animals were subsequently euthanized at days 7 and 28 post-operatively.The gross morphology,neuronal survival,and myelin sheath in the injured area were evaluated using hematoxylin and eosin(HE),Nissl,and luxol fast blue(LFB)staining,respectively.Immunofluorescence staining was used to observe CD31 expression 7 days post-injury.Furthermore,the expression of CD31,neuronal nuclear protein(NeuN),and myelin basic protein(MBP)were evaluated 28 days post-injury.Additionally,vascular endothelial growth factor A(VEGFA)and VEGF receptor-2(VEGFR-2)expression was evaluated using western blotting.Whole-blood viscosity,plasma viscosity,and red blood cell aggregation were measured using a hemorheometer.Results:From postoperative days 3-28,motor function in the BYHWD group began to recover consid-erably compared to the SCI group.BYHWD effectively restored spinal cord histopathology.In addition,the number of NeuN-positive cells,and fluorescence intensity of CD31at 7 and 28 days and MBP significantly increased in the BYHWD group compared with the SCI group(all P＜.05).Moreover,this decoction significantly upregulated the expression of VEGFA and VEGFR-2(all P＜.05).BYHWD improved the hemorheology results(i.e.,except erythrocyte aggregation index in the low-dose group),revealing statistically significant differences compared with the SCI group(all P＜.05).Conclusion:BYHWD effectively promoted angiogenesis,improved hemorheological parameters,and protected neurons and myelin sheaths,ultimately promoting the recovery of neurological function after cervical SCI in rats.These findings suggest that BYHWD promotes vascular neogenesis through the VEGFA/VEGFR-2 pathway.
      原文链接:
    • 国家科技期刊平台
    • NETL
    • NSTL
    • 万方数据