查看更多>>摘要：Forkhead box J3(FOXJ3)is a member of the forkhead box(Fox)family.Recently,increasing evidence has revealed the rela-tionship between Fox family members and cancer.FOXJ3 is involved in various types of cancer,including lung cancer,tongue squamous carcinoma,and prostate cancer;however,a comprehensive pan-cancer analysis of FOXJ3 remains lacking.Here,we explored the function of FOXJ3 across cancers using online websites and databases including TIMER2.0,SangerBox,UALCAN,GEPIA2.0,cBioPortal,Cancer-SEA,STRING,BioGRID and Metascape to analyze the role of FOXJ3 in cancers.Abnormal expression of FOXJ3 was found in various tu-mors.The genetic alteration percentage in tumors was determined,and elevated FOXJ3 expression was found to be associated with worse overall survival in brain lower grade glioma(LGG),liver hepatocellular carcinoma(LIHC),sarcoma(SARC)and thyroid carcinoma.El-evated FOXJ3 expression was related to worse prognosis with disease-free survival in adrenocortical carcinoma,LGG and LIHC.FOXJ3 expression was related to immune infiltration in several cancers.Enrichment analysis showed that histone modification,the TGF-β signal-ing pathway,and chromatin organization were the top three enriched ontology clusters of the top 100 similar genes of FOXJ3.Our pan-cancer analysis provides comprehensive insights into FOXJ3 from the perspective of bioinformatics in different cancers,where it serves as a potential biomarker for prognosis,especially in LGG and LIHC.FOXJ3 is also correlated with immune infiltrates in certain human tu-mors.
查看更多>>摘要：In the face of the elevated incidence and mortality rate of septic shock in the ICU,this retrospective study seeks to investigate the indicative and predictive value of high-mobility group box 1(HMGB1)and miR-146b in patients with septic shock.Quantitative RT-PCR was employed in this study to quantify the HMGB1 and miR-146b levels in plasma samples obtained from the patient group and healthy controls.The investigation involved the comparison between the two groups and tracking changes in the patient group over time.The finding revealed that upon admission,the patient group exhibited markedly elevated relative expression levels of HMGB1,which sub-sequently decreased over time.Conversely,the patient group displayed significantly reduced relative expression levels of miR-146b upon admission,which subsequently increased over time compared to the control group.Receiver operating characteristic(ROC)curves showed good predictive value for HMGB1 and miR-146b.The experimental results suggest that HMGB1 and miR-146b serve as valuable and con-venient biomarkers for evaluating the severity of septic shock and predicting mortality.Additionally,it is proposed that serum miR-146b may be inducible and potentially exerts a negative regulatory effect on the expression of HMGB1.
万方数据
维普