首页期刊导航|世界胃肠病学杂志（英文版）
期刊信息/Journal information
世界胃肠病学杂志（英文版）
世界胃肠病学杂志（英文版）

潘伯荣

周刊

1007-9327

wjg@wjgnet.com

010-85381901-628

100025

北京市朝阳区东四环中路62号楼远洋国际中心D座903室

世界胃肠病学杂志（英文版）/Journal World Journal of GastroenterologyCSCDCSTPCDSCI
查看更多>>主要报道和刊登国内外、特别是我国消化病学者具有创造性的、有较高学术水平的基础和临床研究论文、研究快报等. 对具有中国特色的研究论文, 如食管癌、胃癌、肝癌、大肠癌、病毒性肝炎、幽门螺杆菌、中医中药、中西医结合和基于作者自己研究工作为主的综述性论文, 将优先发表. 读者对象为基础研究或临床研究的消化专业工作者。
正式出版
收录年代

    An epidemiological study of collagenous colitis in southern Sweden from 2001-2010

    Lina VigrenMartin OlesenCecilia BenoniKlas Sj(o)berg...
    2821-2826页
    查看更多>>摘要：AIM:To estimate the incidence of collagenous colitis (CC) in southern Sweden during 2001-2010.METHODS:Cases were identified by searching for CC in the diagnostic registers at the Pathology Departments in the county of Sk(a)ne.The catchment area comprised the south-west part of the county (394 307 inhabitants in 2010) and is a mixed urban and rural type with limited migration.CC patients that had undergone colonoscopy during the defined period and were living in this area were included in the study regardless of where in Sk(a)ne they had been diagnosed.Medical records were scrutinized and uncertain cases were reassessed to ensure that only newly diagnosed CC cases were included.The diagnosis of CC was based on both clinical and histopathological criteria.The clinical criterion was non-bloody watery diarrhoea.The histopathological criteria were a chronic inflammatory infiltrate in the lamina propria,a thickened subepithelial collagen layer ≥ 10 micrometers (μm) and epithelial damage such as flattening and detachment.RESULTS:During the ten year period from 2001-2010,198 CC patients in the south-west part of the county of Sk(a)ne in southern Sweden were newly diagnosed.Of these,146 were women and 52 were men,i.e,a female:male ratio of 2.8:1.The median age at diagnosis was 71 years (range 28-95/inter-quartile range 59-81); for women median age was 71 (range 28-95) years and was 73 (range 48-92) years for men.The mean annual incidence was 5.4/105 inhabitants.During the time periods 2001-2005 and 2006-2010,the mean annual incidence rates were 5.4/105 for both periods [95％ confidence interval (CI):4.3-6.5 in 2001-2005 and 4.4-6.4 in 2006-2010,respectively,and 4.7-6.2 for the whole period].Although the incidence varied over the years (minimum 3.7 to maximum 6.7/105) no increase or decrease in the incidence could be identified.The odds ratio (OR) for CC in women compared to men was estimated to be 2.8 (95％ CI:2.0-3.7).The OR for women 65 years of age or above compared to below 65 years of age was 6.9 (95％ CI:5.0-9.7),and for women 65 years of age or above compared to the whole group the OR was 4.7 (95％ CI:3.6-6.0).The OR for age in general,i.e,above or 65 years of age compared to those younger than 65 was 8.3 (95％ CI:6.2-11.1).During the last decade incidence figures for CC have also been reported from Calgary,Canada during 2002-2004 (4.6/105) and from Terrassa,Spain during 2004-2008 (2.6/105).Our incidence figures from southern Sweden during 2001-2010 (5.4/105) as well as the incidence figures presented in the studies during the 1990s (Terrassa,Spain during 1993-1997 (2.3/105),Olrmsted,United States during 1985-2001 (3.1/105),(o)rebro,Sweden during 1993-1998 (4.9/105),and Iceland during 1995-1999 (5.2/105) are all in line with a northsouth gradient,something that has been suggested before beth for CC and inflammatory bowel disease.CONCLUSION:The observed incidence of CC is comparable with previous reports from northern Europe and America.The incidence is stable but the female:male ratio seems to be decreasing.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

    Evaluation of SNPs in miR-196-a2, miR-27a and miR-146a as risk factors of colorectal cancer

    Renata HezovaAlena KovarikovaJulie Bienertova-VaskuMilana Sachlova...
    2827-2831页
    查看更多>>摘要：AIM:To investigate whether selected single nucleotide polymorphisms (SNPs) in miR-196a2,miR-27a and miR146a genes are associated with sporadic colorectal cancer (CRC).METHODS:In order to investigate the effect of these SNPs in CRC,we performed a case-control study of 197 cases of sporadic CRC and 212 cancer-free controls originating from the Central-European Caucasian population using TaqMan Real-Time polymerase chain reaction and allelic discrimination analysis.RESULTS:The genotype and allele frequencies of SNPs were compared between the cases and the controis.None of the performed analysis showed any statistically significant results.CONCLUSION:Our data suggest a lack of association between rs11614913,rs895819 and rs2910164 and colorectal cancer risk in the Central-European Caucasian population,a population with an extremely high incidence of sporadic colorectal cancer.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

    Progression of remnant gastric cancer is associated with duration of follow-up following distal gastrectomy

    Shuhei KomatsuDaisuke Ichikawa, Kazuma OkamotoDaito Ikoma...
    2832-2836页
    查看更多>>摘要：AIM:To re-evaluate the recent clinicopathological features of remnant gastric cancer (RGC) and to develop desirable surveillance programs.METHOIDS:Between 1997 and 2008,1149 patients underwent gastrectomy for gastric cancer at the Department of Digestive Surgery,Kyoto Prefectural University of Medicine,Japan.Of these,33 patients underwent gastrectomy with lymphadenectomy for RGC.Regarding the initial gastric disease,there were 19 patients with benign disease and 14 patients with gastric cancer.The hospital records of these patients were reviewed retrospectively.RESULTS:Concerning the initial gastric disease,the RGC group following gastric cancer had a shorter interval [P ＜ 0.05; gastric cancer vs benign disease:12 (2-22) vs 30 (4-51) years] and were more frequently reconstructed by Billroth- I procedure than those following benign lesions (P ＜ 0.001).Regarding reconstruction,RGC following Billroth-Ⅱ reconstruction showed a longer interval between surgical procedures [P ＜ 0.001; Billroth- 11 vs Billroth- Ⅰ:32 (5-51) vs 12 (2-36) years] and tumors were more frequently associated with benign disease (P ＜ 0.001) than those following Billroth- I reconstruction.In tumor location of RGC,after Billroth- I reconstruction,RGC occurred more frequently near the suture line and remnant gastric wall.After Billroth- Ⅱ reconstruction,RGC occurred more frequently at the anastomotic site.The duration of followup was significantly associated with the stage of RGC (P ＜ 0.05).Patients diagnosed with early stage RGC such as stage I -Ⅱ tended to have been followed up almost every second year.CONCLUSION:Meticulous follow-up examination and early detection of RGC might lead to a better prognosis.Based on the initial gastric disease and the procedure of reconstruction,an appropriate follow-up interval and programs might enable early detection of RGC.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

    Role of ascites adenosine deaminase in differentiating between tuberculous peritonitis and peritoneal carcinomatosis

    Seung JooKangJi Won KimJee Hyun BaekSe Hyung Kim...
    2837-2843页
    查看更多>>摘要：AIM:To investigate the usefulness of tumor markers and adenosine deaminase in differentiating between tuberculous peritonitis (TBP) and peritoneal carcinomatosis (PC).METHODS:A retrospective analysis of data was performed on consecutive patients who underwent peritoneoscopic and abdominal computed tomography (CT) evaluations.Among 75 patients at the Seoul National University Hospital from January 2000 to June 2010 who underwent both tests,27 patients (36.0％) and 25 patients (33.3％) were diagnosed with TBP and PC,respectively.Diagnosis was confirmed by peritoneoscopic biopsy.RESULTS:Serum c-reactive protein (7.88 ± 6.62 mg/ dL vs 3.12 ± 2.69 mg/dL,P =0.01),ascites adenosine deaminase (66.76 ± 32.09 IU/L vs 13.89 ± 8.95 IU/L,P ＜ 0.01),ascites lymphocyte proportion (67.77 ± 23.41％ vs 48.36 ± 18.78％,P ＜ 0.01),and serum ascites albumin gradient (0.72±0.49 g/dL vs 1.05 ± 0.50 g/dL,P =0.03) were significantly different between the two groups.Among tumor markers,serum and ascites carcinoembryonic antigen,serum carbohydrate antigen 19-9 showed significant difference between two groups.Abdominal CT examinations showed that smooth involvement of the parietal peritoneum was more common in the TBP group (77.8％ vs 40.7％) whereas nodular involvement was more common in the PC group (14.8％ vs 40.7％,P =0.04).From receiver operating characteristic (ROC) curves ascites adeno sines deaminase (ADA) showed better discriminative capability than tumor markers.An ADA cut-off level of 21 IU/L was found to yield the best results of differential diagnosis; sensitivity,specificity,positive predictive value,and negative predictive value were 92.0％,85.0％,88.5％ and 89.5％,respectively.CONCLUSION:Besides clinical and radiologic findings,ascitic fluid ADA measurement is helpful in the differential diagnosis of TBP and PC.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

    XAF1 is frequently methylated in human esophageal cancer

    Xiang-Yu ChenQiao-Yu HeMing-Zhou Guo
    2844-2849页
    查看更多>>摘要：AIM:To explore epigenetic changes in the gene encoding X chromosome-linked inhibitor of apoptosis-associated factor 1 (XAF1) during esophageal carcinogenesis.METHODS:Methylation status of XAF1 was detected by methylation-specific polymerase chain reaction (MSP) in four esophageal cancer cell lines (KYSE30,KYSE70,BIC1 and partially methylated in TE3 cell lines),nine cases of normal mucosa,72 cases of primary esophageal cancer and matched adjacent tissue.XAF1 expression was examined by semi-quantitative reverse transcriptional polymerase chain reaction and Western blotting before and after treatment with 5-aza-deoxycytidine (5-aza-dc),a demethylating agent.To investigate the correlation of XAF1 expression and methylation status in primary esophageal cancer,immunohistochemistry for XAF1 expression was performed in 32 cases of esophageal cancer and matched adjacent tissue.The association of methylation status and clinicopathological data was analyzed by logistic regression.RESULTS:MSP results were as follows:loss of XAF1 expression was found in three of four esophageal cell lines with promoter region hypermethylation (com pletely methylated in KYSE30,KYSE70 and BIC1 cell lines and partially in TE3 cells); all nine cases of normal esophageal mucosa were unmethylated; and 54/72 (75.00％) samples from patients with esophageal cancer were methylated,and 25/72 (34.70％) matched adjacent tissues were methylated (75.00％ vs 34.70％,x2 =23.5840,P =0.000).mRNA level of XAF1 measured with semi-quantitative reverse transcription polymerase chain reaction was detectable only in TE3 cells,and no expression was detected in KYSE30,KYSE70 or BIC1 cells.Protein expression was not observed in KYSE30 cells by Western blotting before treatment with 5-aza-dc.After treatment,mRNA level of XAF1 was detectable in KYSE30,KYSE70 and BIC1 cells.Protein expression was detected in KYSE30 after treatment with 5-aza-dc.Immunohistochemistry was performed on 32 cases of esophageal cancer and adjacent tissue,and demonstrated XAF1 in the nucleus and cytoplasm.XAF1 staining was found in 20/32 samples of adjacent normal tissue but was present in only 8/32 samples of esophageal cancer tissue (x2=9.143,P =0.002).XAF1 expression was decreased in cancer samples compared with adjacent tissues.In 32 cases of esophageal cancer,24/32 samples were methylated,and 8/32 esophageal cancer tissues were unmethylated.XAF1 staining was found in 6/8 samples of unmethylated esophageal cancer and 2/24 samples of methylated esophageal cancer tissue.XAF1 staining was inversely correlated with XAF1 promoter region methylation (Fisher's exact test,P =0.004).Regarding methylation status and clinicopathological data,no significant differences were found in sex,age,tumor size,tumor stage,or metastasis with respect to methylation of XAF1 for the 72 tissue samples from patients with esophageal cancer.CONCLUSION:XAF1 is frequently methylated in esophageal cancer,and XAF1 expression is regulated by promoter region hypermethylation.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

    DNA-dependent activator of interferon-regulatory factors inhibits hepatitis B virus replication

    Qi-Ying ChenYing-Hui LiuJian-Hua LiZe-Kun Wang...
    2850-2858页
    查看更多>>摘要：AIM:To investigate whether DNA-dependent activator of interferon-regulatory factors (DAI) inhibits hepatitis B virus (HBV) replication and what the mechanism is.METHODS:After the human hepatoma cell line Huh7 was cotransfected with DAI and HBV expressing plasmid,viral protein (HBV surface antigen and HBV e antigen) secretion was detected by enzyme-linked immunosorbent assay,and HBV RNA was analyzed by realtime polymerase chain reaction and Northern blotting,and viral DNA replicative intermediates were examined by Southern blotting.Interferon regulatory factor 3 (IRF3) phosphorylation and nuclear translocation were analyzed via Western blotting and immunofluorescence staining respectively.Nuclear factor-kB (NF-KB) activity induced by DAI was detected by immunofluorescence staining of P65 and dual luciferase reporter assay.Transwell co-culture experiment was performed in order to investigate whether the antiviral effects of DAI were dependent on the secreted cytokines.RESULTS:Viral protein secretion was significantly reduced by 57％ (P ＜ 0.05),and the level of total HBV RNA was reduced by 67％ (P ＜ 0.05).The viral core particle-associated DNA was also dramatically downregulated in DAI-expressing Huh7 cells.Analysis of involved signaling pathways revealed that activation of NF-kB signaling was essential for DAI to elicit antiviral response in Huh7 cells.When the NF-kB signaling pathway was blocked by a NF-KB signaling suppressor (IKBα-SR),the anti-HBV activity of DAI was remarkably abrogated.The inhibitory effect of DAI was independent of IRF3 signaling and secreted cytokines.CONCLUSION:This study demonstrates that DAI can inhibit HBV replication and the inhibitory effect is associated with activation of NF-KB but independent of IRF3 and secreted cytokines.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

    Double balloon enteroscopy in the old: Experience from China

    Qiong HeQiang ZhangJian-Dong LiYa-Dong Wang...
    2859-2866页
    查看更多>>摘要：AIM:To evaluate the safety,efficacy and management of double balloon enteroscopy (DBE) carried out in those aged individuals with suspicious small intestine diseases.METHODS:DBE is a wonderful invention of the past decade and is widely used as an examination tool for the gastrointestinal tract.From January 2003 to July 2011,data from patients who were ≥ 65 years old and underwent DBE examination in the Nanfang Hospital were included in a retrospective analysis.RESULTS:Fifty-nine individuals were found and subsequently analyzed.The mean age was 69.63 ± 3.89 years (range 65-84),34 were males.Indications for DBE were melena/hematochezia (36 cases),abdominal pain (15 cases),diarrhea (3 cases),stool change (1 case),weight loss (1 case),vomiting (2 cases),and de bilitation (1 case).The average duration of symptoms was 33.34 ± 64.24 mo.Twenty-seven patients suffered from age-related diseases.Severe complications were not found during and after DBE.Comparison between systolic and diastolic blood pressure before and after DBE was statistically significant (mean ± SD,P ＜ 0.01,P ＜ 0.05,respectively).Small bowel pathologies were found by DBE in 35 patients,definite diagnoses were made in 31 cases,and detection rate and diagnostic yield for DBE were 68.6％ and 60.8％,respectively.CONCLUSION:DBE is a safe and effective method for gastrointestinal examination in the aged population.Aging alone is not a risk factor for elderly patients with suspicious gastrointestinal diseases and thorough preparation prior to the DBE procedure should be made for individuals with multiple diseases especially cardiopulmonary disorders.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

    Intervention of Mirtazapine on gemcitabine-induced mild cachexia in nude mice with pancreatic carcinoma xenografts

    Shu-Man JiangJian-Hua WuLin Jia
    2867-2871页
    查看更多>>摘要：AIM:To investigate the effect of Mirtazapine on tumor growth,food intake,body weight,and nutritional status in gemcitabine-induced mild cachexia.METHODS:Fourteen mice with subcutaneous xenografts of a pancreatic cancer cell line (SW1990) were randomly divided into Mirtazapine and control groups.Either Mirtazapine (10 mg/kg) or saline solution was orally fed to the mice every day after tumor implantation.A model of mild cachexia was then established in both groups by intraperitoneal injection of Gemcitabine (50 mg/kg) 10 d,13 d,and 16 d after tumor implantation.Tumor size,food intake,body weight,and nutritional status were measured during the experiment.All mice were sacrificed at day 28.RESULTS:(1) After 7 d of gemcitabine administration,body-weight losses of 5％-7％ which suggested mild cachexia were measured; (2) No significant difference in tumor size was detected between the Mirtazapine and control groups (P ＞ 0.05); and (3) During the entire experimental period,food intake and body weight were slightly greater for the Mirtazapine group compared with controls (although these differences were not statistically significant).After 21 d,mice in the Mirtazapine group consumed significantly more food than control mice (3.95 ± 0.14 g vs 3.54 ± 0.10 g,P =0.004).After 25 d,mice in the Mirtazapine group were also significantly heavier than control mice (17.24 ± 0.53 g vs 18.05 ± 0.68 g,P =0.014).CONCLUSION:Mild cachexia model was successfully established by gemcitabine in pancreatic tumor-bearing mice.Mirtazapine can improve gemcitabine-induced mild cachexia in pancreatic tumor-bearing mice.It was believed to provide a potential therapeutic perspective for further studies on cachexia.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

    Bleeding duodenal hemangioma: Morphological changes and endoscopic mucosal resection

    Noriko NishiyamaHirohito MoriHideki KobaraShintarou Fujihara...
    2872-2876页
    查看更多>>摘要：Recently,the development of endoscopic procedures has increased the availability of minimally invasive treatments; however,there have been few case reports of duodenal hemangioma treated by endoscopic mucosal resection.The present report describes a case of duodenal hemangioma that showed various endoscopic changes over time and was treated by endoscopic mucosal resection.An 80-year-old woman presented with tarry stools and a loss of appetite.An examination of her blood revealed severe anemia,and her hemoglobin level was 4.2 g/dL.An emergency upper gastrointestinal endoscopy was performed.A red,protrusive,semipedunculated tumor (approximately 20 mm in diameter) with spontaneous bleeding on its surface was found in the superior duodenal angle.Given the semipedunculated appearance of the tumor,it was suspected to be an epithelial tumor with a differential diagnosis of hyperplastic polyp.The biopsy results suggested a telangiectatic hemangioma.Because this lesion was considered to be responsible for her anemia,endoscopic mucosal resection was performed for diagnostic and treatment purposes after informed consent was obtained.A histopathological examination of the resected specimen revealed dilated and proliferated capillary lumens of various sizes,which confirmed the final diagnosis of duodenal hemangioma.Neither anemia nor tumor recurrence has been observed since the endoscopic mucosal resection (approximately 1 year).Duodenal hemangiomas can be treated endoscopically provided that sufficient consideration is given to all of the possible treatment strategies.Interestingly,duodenal hemangiomas show morphological changes that are influenced by various factors,such as mechanical stimuli.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

    Duodenal variceal bleeding after balloon-occluded retrograde transverse obliteration: Treatment with transjugular intrahepatic portosystemic shunt

    Min Joung KimByoung Kuk JangWoo Jin ChungJae Seok Hwang...
    2877-2880页
    查看更多>>摘要：We report a case of duodenal varix bleeding as a long term complication of balloon occluded retrograde transvenous obliteration (BRTO),which was successfully treated with a transjugular intrahepatic portosystemic shunt (TIPS).A 57-year-old man was admitted to the emergency room suffering from melena.He had undergone BRTO to treat gastric varix bleeding 5 mo before admission.Endoscopy and a computed tomography (cr) scan showed complete obliteration of the gastric varix,but the nodular varices in the second portion of the duodenum expanded after BRTO,and spurting blood was seen.TIPS was performed for treatment of duodenal variceal bleeding,because attempts at endoscopic varix ligation were unsuccessful.The postoperative course was uneventful and the patient was discharged without complications.A follow up CT scan obtained 21 mo after TIPS revealed a patent TIPS tract and complete obliteration of duodenal varices,but multinodular hepatocellular carcinoma had developed.He died of hepatic failure 28 mo after TIPS.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普