首页|Evaluation of SNPs in miR-196-a2, miR-27a and miR-146a as risk factors of colorectal cancer

Evaluation of SNPs in miR-196-a2, miR-27a and miR-146a as risk factors of colorectal cancer

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  • NSTL
  • 万方数据
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AIM:To investigate whether selected single nucleotide polymorphisms (SNPs) in miR-196a2,miR-27a and miR146a genes are associated with sporadic colorectal cancer (CRC).METHODS:In order to investigate the effect of these SNPs in CRC,we performed a case-control study of 197 cases of sporadic CRC and 212 cancer-free controls originating from the Central-European Caucasian population using TaqMan Real-Time polymerase chain reaction and allelic discrimination analysis.RESULTS:The genotype and allele frequencies of SNPs were compared between the cases and the controis.None of the performed analysis showed any statistically significant results.CONCLUSION:Our data suggest a lack of association between rs11614913,rs895819 and rs2910164 and colorectal cancer risk in the Central-European Caucasian population,a population with an extremely high incidence of sporadic colorectal cancer.

Association studyColorectal cancerMicroRNASingle nucleotide polymorphism

Renata Hezova、Alena Kovarikova、Julie Bienertova-Vasku、Milana Sachlova、Martina Redova、Anna Vasku、Marek Svoboda、Lenka Radova、Igor Kiss,、Rostislav Vyzula,、Ondrej Slaby

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Department of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute, Zluty kopec 7, 656 53 Bmo, Czech

Department of Pathological Physiology, Faculty of Medicine, Masaryk University,Karnenice 5, 625 00 Bmo, Czech

Central European Institute of Technology, Masaryk University, 625 00 Bmo, Czech

Lenka Radova, Laboratory of Experimental Medicine, Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University and Palacky University Affiliated Hospital Olomouc, 775 15 Olomouc, Czech

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Czech Ministry of ttealthCzech Ministry of ttealthCzech Ministry of ttealthMinistry of Education,Youth and Sports for the project BBMRI CZproject "CEITEC-Central European Institute of Technology"

NS 10352-3/2009NS/9814project MZ0MOU2005LM2010004CZ.1.05/1.1.00/02.0068

2012

10.3748/wjg.v18.i22.2827

世界胃肠病学杂志(英文版)
太原消化病研治中心

世界胃肠病学杂志(英文版)

SCI
影响因子：1.001
ISSN：1007-9327
年,卷(期)：2012.(22)
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