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世界胃肠病学杂志（英文版）
世界胃肠病学杂志（英文版）

潘伯荣

周刊

1007-9327

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世界胃肠病学杂志（英文版）/Journal World Journal of GastroenterologyCSCDCSTPCDSCI
查看更多>>主要报道和刊登国内外、特别是我国消化病学者具有创造性的、有较高学术水平的基础和临床研究论文、研究快报等. 对具有中国特色的研究论文, 如食管癌、胃癌、肝癌、大肠癌、病毒性肝炎、幽门螺杆菌、中医中药、中西医结合和基于作者自己研究工作为主的综述性论文, 将优先发表. 读者对象为基础研究或临床研究的消化专业工作者。
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    Inflammation-and stress-related signaling pathways in hepatocarcinogenesis

    Hayato NakagawaShin Maeda
    4071-4081页
    查看更多>>摘要：It has been established that cancer can be promoted and exacerbated by inflammation.Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide,and its long-term prognosis remains poor.Although HCC is a complex and heterogeneous tumor with several genomic mutations,it usually develops in the context of chronic liver damage and inflammation,suggesting that understanding the mechanism(s) of inflammation-mediated hepatocarcinogenesis is essential for the treatment and prevention of HCC.Chronic liver damage induces a persistent cycle of necroinflammation and hepatocyte regeneration,resulting in genetic mutations in hepatocytes and expansion of initiated cells,eventually leading to HCC development.Recently,several inflammation-and stress-related signaling pathways have been identified as key players in these processes,which include the nuclear factorκB,signal transducer and activator of transcription,and stress-activated mitogen-activated protein kinase pathways.Although these pathways may suggest potential therapeutic targets,they have a wide range of functions and complex crosstalk occurs among them.This review focuses on recent advances in our understanding of the roles of these signaling pathways in hepatocarcinogenesis.
      原文链接:
    • NETL
    • NSTL
    • 万方数据

    Indomethacin for post-endoscopic retrograde cholangiopancreatography pancreatitis prophylaxis: Is it the magic bullet?

    Dennis YangPeter V Draganov
    4082-4085页
    查看更多>>摘要：Acute pancreatitis is a common complication of endoscopic retrograde cholangiopancreatography (ERCP).Pancreatic duct stent insertion after ERCP has been widely accepted as the standard of care for the prevention of this complication in high-risk patients.Unfortunately,the placement of pancreatic stents requires higher level of endoscopic expertise and is not always feasible due to anatomic considerations.Therefore,effective non-invasive pharmacologic prophylaxis remains appealing,particularly if it is inexpensive,easily administered,has a low risk side effect profile and is widely available.There have been multiple studies evaluating potential pharmacologic candidates for post-ERCP pancreatitis (PEP) prophylaxis,most of them yielding disappointing results.A recently published large,multicenter,randomized controlled trial reported that in high risk patients a single dose of rectal indomethacin administered immediately after the ERCP significantly decreased the incidence of PEP compare to placebo.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

    Three-dimensional image reconstruction in capsule endoscopy

    Anastasios KoulaouzidisAlexandros Karargyris
    4086-4090页
    查看更多>>摘要：To date,limited research has been carried out in developing methods and materials that offer three-dimensional (3-D) representation of the digestive tract.In the field of capsule endoscopy (CE),hardware approaches have been developed that provide real time both 3-D information and texture using an infrared projector and a complementary metal oxide semiconductor camera.The major drawbacks of this system are its size,power consumption and packaging issues.A software approach to approximate a 3-D representation of digestive tract surface utilising current CE technology has been proposed.The algorithm utilizes the Shape from Shading technique and seem to provide promising results for polypoid structures and angioectasias.Further clinical evaluation is currently under way.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

    Colorectal cancer in patients with inflammatory bowel disease: Can we predict risk?

    Vibeke AndersenJonas HalfvarsonUlla Vogel
    4091-4094页
    查看更多>>摘要：The inflammatory bowel diseases (IBD),Crohn's disease (CD) and ulcerative colitis (UC),may be complicated by colorectal cancer (CRC).In a recent populationbased cohort study of 47 347 Danish patients with IBD by Tine Jess and colleagues 268 patients with UC and 70 patients with CD developed CRC during 30 years of observation.The overall risk of CRC among patients with UC and CD was comparable with that of the general population.However,patients diagnosed with UC during childhood or as adolescents,patients with long duration of disease and those with concomitant primary sclerosing cholangitis were at increased risk.In this commentary,we discuss the mechanisms underlying carcinogenesis in IBD and current investigations of genetic susceptibility in IBD patients.Further advances will depend on the cooperative work by epidemiologist and molecular geneticists in order to identify genetic polymorphisms involved in IBD-associated CRC.The ultimate goal is to incorporate genotypes and clinical parameters into a predictive model that will refine the prediction of risk for CRC in colonic IBD.The challenge will be to translate these new findings into clinical practice and to determine appropriate preventive strategies in order to avoid CRC in IBD patients.The achieved knowledge may also be relevant for other inflammation-associated cancers.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

    Is enteroscopy necessary for diagnosis of celiac disease?

    Taylan KavBulent Sivri
    4095-4101页
    查看更多>>摘要：Celiac disease (CD) is an autoimmune inflammatory disease of the small intestine as a result of reaction to wheat protein,gluten.Exclusion of dietary gluten is the mainstay of the treatment that necessitates a precise diagnosis of the disease.Serological screening may aid in identifying patients with suspected CD,which should be confirmed by intestinal biopsy.It has been shown that duodenal biopsies are good for detection of the disease in most patients.However,there is a group of patients with positive serology and inconclusive pathology.As a result of the widespread use of serology,many patients with equivocal findings grow quickly.Unfortunately current endoscopic methods can only diagnose villous atrophy,which can be present in the later grades of disease (i.e.,Marsh Ⅲ).To diagnose CD correctly,going deeper in the intestine may be necessary.Enteroscopy can reveal changes in CD in the intestinal mucosa in 10％-17％ of cases that have negative histology at initial workup.Invasiveness of the method limits its use.Capsule endoscopy may be a good substitute for enteroscopy.However,both techniques should be reserved for patients with suspected diagnosis of complications.This paper reviews the current literature in terms of the value of enteroscopy for diagnosis of CD.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

    Diffusion-weighted imaging of biliopancreatic disorders:Correlation with conventional magnetic resonance imaging

    Nam Kyung LeeSuk KimGwang Ha KimDong Uk Kim...
    4102-4117页
    查看更多>>摘要：Diffusion-weighted magnetic resonance imaging (DWI) is a well established method for the evaluation of intracranial diseases,such as acute stroke.DWI for extracranial application is more difficult due to physiological motion artifacts and the heterogeneous composition of the organs.However,thanks to the newer technical development of DWI,DWI has become increasingly used over the past few years in extracranial organs including the abdomen and pelvis.Most previous studies of DWI have been limited to the evaluation of diffuse parenchymal abnormalities and focal lesions in abdominal organs,whereas there are few studies about DWI for the evaluation of the biliopancreatic tract.Although further studies are needed to determine its performance in evaluating bile duct,gallbladder and pancreas diseases,DWI has potential in the assessment of the functional information on the biliopancreatic tract concerning the status of tissue cellularity,because increased cellularity is associated with impeded diffusion,as indicated by a reduction in the apparent diffusion coefficient.The detection of malignant lesions and their differentiation from benign tumor-like lesions in the biliopancreatic tract could be improved using DWI in conjunction with findings obtained with conventional magnetic resonance cholagiopancreatography.Additionally,DWI can be useful for the assessment of the biliopancreatic tract in patients with renal impairment because contrast-enhanced computed tomography or magnetic resonance scans should be avoided in these patients.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

    Efficacy of MK615 for the treatment of patients with liver disorders

    Atsushi HokariTomohisa IshikawaHisao TajiriTakahide Matsuda...
    4118-4126页
    查看更多>>摘要：AIM:To investigate the hepatoprotective effect of MK615,a Japanese apricot extract,in an animal model,and its clinical therapeutic effect.METHODS:Wistar rats were administered physiological saline (4 mL/kg) or MK615 solution (4 mL/kg) for 7 d.On the sixth d,acute hepatic injury was induced by administering a single intraperitoneal injection (ip) of D-galactosamine hydrochloride (D-GalN) (600 mg/kg).Plasma levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were determined,and liver tissues were used for histopathological analysis.Fifty-eight patients with liver disorders [hepatitis C (n =40),non-alcoholic fatty liver disease (n =15),and autoimmune liver disease (n =3)] were orally administered commercially available Misatol ME-containing MK615 (13 g/d) daily for 12 wk.Blood and urine were sampled immediately before and 6 wk,12 wk,and 16 wk after the start of intake to measure various biochemical parameters.The percentage change in ALT and AST levels after 12 wk from the pre-intake baseline served as a primary endpoint.RESULTS:D-GalN effectively induced acute hepatic injury in the rats.At 48 h after the ip injection of D-GalN,the plasma levels of ALT (475.6 ± 191.5 IU/L vs 225.3 ± 194.2 IU/L,P ＜ 0.05) and AST (1253.9 ± 223.4 IU/L vs 621.9 ± 478.2 IU/L,P ＜ 0.05) in the MK615 group were significantly lower than the control group.Scattered single cell necrosis,loss of hepatocytes,and extensive inflammatory cell infiltration were observed in hepatic tissue samples collected from the control group.However,these findings were less pronounced in the group receiving MK615.At the end of the clinical study,serum ALT and AST levels were significantly decreased compared with pre-intake baseline levels from 103.5 ± 58.8 IU/L to 71.8 ± 39.3 IU/L (P ＜ 0.05) and from 93.5 ± 55.6 IU/L to 65.5 ± 34.8 IU/L (P ＜ 0.05),respectively.A reduction of ≥ 30％ from the pre-study baseline ALT level was observed in 26 (45％) of the 58 patients,while 25 (43％) patients exhibited similar AST level reductions.The chronic hepatitis C group exhibited significant ALT and AST level reductions from 93.4 ± 51.1 IU/L to 64.6 ± 35.1 IU/L (P ＜ 0.05) and from 94.2 ± 55.5 IU/L to 67.2 ± 35.6 IU/L (P ＜ 0.05),respectively.A reduction of ≥ 30％ from the pre-study baseline ALT level was observed in 20 (50％) of the 40 patients.ALT levels in both the combined ursodeoxycholic acid (UDCA) treatment and the UDCA uncombined groups were significantly lower after Misatol ME administration.MK615 protected hepatocytes from D-GaiN-induced cytotoxicity in rats.Misatol ME decreased elevated ALT and AST levels in patients with liver disorders.CONCLUSION:These results suggest that MK615 and Misatol ME are promising hepatoprotective agents for patients with liver disorders.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

    siRNA-mediated downregulation of TC21 sensitizes esophageal cancer cells to cisplatin

    Md.Raghibul HasanShyam Singh ChauhanRinu SharmaRanju Ralhan...
    4127-4135页
    查看更多>>摘要：AIM:To determine the functional significance of TC21 in esophageal squamous cell carcinoma (ESCC).METHODS:TC21 siRNA transfection was carried out using Hyperfectamine to knock down TC21,and transcripts were analyzed by reverse transcription-polymerase chain reaction and protein by Western blotting.We demonstrated the effect of TC21 downregulation of cell signaling in esophageal cancer cells by assessing the phosphorylation status of its downstream targets,phosphoinositide 3-kinase (PI3K),phosphatase and tensin homolog (PTEN),protein kinase B (pAkt),nuclear factor-κB (NF-κB) and cyclinD1 using specific antibodies.Cell survival analysis after cisplatin treatment was carried out by cell viability assay and cell cycle analysis using flow cytometry.RESULTS:TC21 knockdown in human ESCC cell line TE13 cells,showed only a marginal increase (14.2％) in cell death compared with control cells.The expressions of the signaling proteins PI3K and pAkt,transcription factor NF-κB,and cell cycle protein cyclin D1 were markedly decreased in response to TC21 downregulation,whereas the level of pPTEN,an antagonist of PI3K,was increased.In addition,we evaluated the potential of TC21 as a putative target for sensitizing ESCC cells to the chemotherapeutic agent dsplatin.Increased cell death (38.4％) was observed in cells treated with cisplatin after TC21 knockdown compared with cells which were treated with cisplatin alone (20％ cell death).CONCLUSION:Results suggest that TC21 mediates its effects via the PI3K-Akt pathway,NF-κB and cydin D1,and enhances chemoresistance in esophageal cancer cells.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

    Double contrast-enhanced two-dimensional and three-dimensional ultrasonography for evaluation of gastric lesions

    Hong ShiXiu-Hua YuXin-Zhang GuoYuan Guo...
    4136-4144页
    查看更多>>摘要：AIM:To investigate the value of two-dimensional (2D) and three-dimensional (3D) double contrast-enhanced ultrasonography (DCUS) imaging for evaluation of gastric lesions.METHODS:2D and 3D DCUS imaging with both oral and intravenous administrations of contrast agents was used to assess gastroscopiclly-confirmed gastric lesions in 46 patients with benign and malignant diseases.Initially,liquid-based ultrasound contrast agent (Xinzhang(R)) was given orally at dose of 500-600 mL for conventional ultrasound examination of the gastric lesions,and then a microbubble-based contrast agent (SonoVue) was injected intravenously at dose of 1.2-2.4 mL in bolus fashion to assess the perfusion pattern of the lesions using contrast imaging modes.The parameters derived from time-intensity curves including the arrival time (AT),time to peak (TTP),peak intensity (PI) and enhanced intensity (EI) were measured on the 2D DCUS imaging.3D DCUS of the lesions was acquired to demonstrate the value of this imaging mode.RESULTS:There were 22 cases with benign lesions including chronic gastritis (n =5),gastric ulcer (n =9),gastric polyps (n =3),gastric stromal tumors (n =5),and 24 cases with malignant lesions including gastric cancer (n =20),gastric cardia carcinoma (n =3) and post-operative recurrent gastric cancer (n =1) in the study.The oral contrast-enhanced ultrasonography (CEUS) imaging of the stomach clearly demonstrated the anatomy of the stomach and morphologic features of gastric lesions.With optimal scanning window and imaging display under oral CEUS,intravenous CEUS clearly showed the perfusion of gastric lesions with various characteristic manifestations.Both 2D and 3D DCUS images clearly demonstrated normal gastric wall as a three-layer structure,from the inside out,hyperechoic mucosa,hypoechoic muscularis and hyperechoic serosa,respectively.There were statistical significant differences of AT (8.68 ± 2.06 vs 10.43 ± 2.75,P =0.017),PI (34.64 ± 6.63 vs 29.58 ± 8.22,P =0.023) and EI (29.72 ± 6.69 vs 22.66 ± 7.01,P =0.001) between malignant lesions and normal gastric wall.However,no differences of AT,PI and EI between benign lesions and normal gastric wall tissue were found.3D DCUS could intuitively display morphological features and vascularities of the lesions with multiplanar and volume views.3D DCUS imaging provided comprehensive information complementary to 2D imaging.The crater or wellhead appearances and feeding vessels as well as distorted nourishing vasculature of gastric carcinoma were better seen with 3D imaging than 2D imaging.CONCLUSION:DCUS imaging can simultaneously display the anatomic and perfusion features of gastric lesions.3D DCUS can provide additional information to 2D DCUS for evaluation of gastric lesions.
      原文链接:
    • NETL
    • NSTL
    • 万方数据

    A comparison of survival and pathologic features of nonalcoholic steatohepatitis and hepatitis C virus patients with hepatocellular carcinoma

    Roberto Hernandez-AlejandroKris P CroomeMartin DrageNathalie Sela...
    4145-4149页
    查看更多>>摘要：AIM:To compare the clinical outcome and pathologic features of non-alcoholic steatohepatitis (NASH) patients with hepatocellular carcinoma (HCC) and hepatitic C virus (HCV) patients with HCC (another group in which HCC is commonly seen) undergoing liver transplantation.METHODS:Patients transplanted for HCV and NASH at our institution from January 2000 to April 2011 were analyzed.All explanted liver histology and pre-transplant liver biopsies were examined by two specialist liver histopathologists.Patient demographics,disease free survival,explant liver characteristics and HCC features (tumour number,cumulative tumour size,vascular invasion and differentiation) were compared between HCV and NASH liver transplant recipients.RESULTS:A total of 102 patients with NASH and 283 patients with HCV were transplanted.The incidence of HCC in NASH transplant recipients was 16.7％ (17/102).The incidence of HCC in HCV transplant recipients was 22.6％ (64/283).Patients with NASH-HCC were statistically older than HCV-HCC patients (P ＜ 0.001).A significantly higher proportion of HCV-HCC patients had vascular invasion (23.4％ vs 6.4％,P =0.002) and poorly differentiated HCC (4.7％ vs 0％,P ＜ 0.001) compared to the NASH-HCC group.A trend of poorer recurrence free survival at 5 years was seen in HCV-HCC patients compared to NASH-HCC who underwent a Liver transplantation (P =0.11).CONCLUSION:Patients transplanted for NASH-HCC appear to have less aggressive tumour features compared to those with HCV-HCC,which likely in part accounts for their improved recurrence free survival.
      原文链接:
    • NETL
    • NSTL
    • 万方数据