首页|Inflammation-and stress-related signaling pathways in hepatocarcinogenesis
Inflammation-and stress-related signaling pathways in hepatocarcinogenesis
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It has been established that cancer can be promoted and exacerbated by inflammation.Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide,and its long-term prognosis remains poor.Although HCC is a complex and heterogeneous tumor with several genomic mutations,it usually develops in the context of chronic liver damage and inflammation,suggesting that understanding the mechanism(s) of inflammation-mediated hepatocarcinogenesis is essential for the treatment and prevention of HCC.Chronic liver damage induces a persistent cycle of necroinflammation and hepatocyte regeneration,resulting in genetic mutations in hepatocytes and expansion of initiated cells,eventually leading to HCC development.Recently,several inflammation-and stress-related signaling pathways have been identified as key players in these processes,which include the nuclear factorκB,signal transducer and activator of transcription,and stress-activated mitogen-activated protein kinase pathways.Although these pathways may suggest potential therapeutic targets,they have a wide range of functions and complex crosstalk occurs among them.This review focuses on recent advances in our understanding of the roles of these signaling pathways in hepatocarcinogenesis.
Hepatocellular carcinomaInflammationNuclear factor-κBMitogen-activated protein kinaseSignal transducer and activator of transcriptionc-Jun NH2-terminal kinasep38Transforming growth factor-activated kinase 1Apoptosis signal-regulating kinase
Hayato Nakagawa、Shin Maeda
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Department of Gastroenterology, University of Tokyo, Tokyo 113-8655, Japan
Department of Gastroenterology, Yokohama City University, Yokohama 236-0004, Japan
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