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中国化学快报（英文版）
中国化学快报（英文版）

梁晓天

月刊

1001-8417

cclbj@imm.ac.cn

010-63165638

100050

北京市先农坛街1号

中国化学快报（英文版）/Journal Chinese Chemical LettersCSCDCSTPCD北大核心SCI
查看更多>>本刊是由中国科协主管、中国化学会主办、中国医学科学院药物所承办的学术期刊，是由著名化学家梁晓天院士主编。是中国化学界通向世界的窗口，内容覆盖化学全领域。本刊的办刊宗旨是“新、快、准”，我们将坚持这个宗旨，力求及时反映化学研究中各个相关领域内的最新进展及热点问题，主要读者群是科研人员、研究生、大学教师。现已被国内外多家数据库收录，如SCI　Search、Chemical Abstract、Research Alert、Chemistry Citation Index、《日本科技文献速报》、万方数据数字化期刊群、中国学术期刊过刊全文数据库、中国学术期刊（光盘版）、中国学术期刊文摘、中文期刊全文数据库、俄罗斯Рж期刊源等。
正式出版
收录年代

    Process analytical technologies and self-optimization algorithms in automated pharmaceutical continuous manufacturing

    Peiwen LiuHui JinYan ChenDerong Wang...
    87-95页
    查看更多>>摘要：The pharmaceutical industry is now paying increased attention to continuous manufacturing.While the revolution to continuous and automated manufacturing is deepening in most of the top pharma compa-nies in the world,the advancement of automated pharmaceutical continuous manufacturing in China is relatively slow due to some key challenges including the lack of knowledge on the related technologies and shortage of qualified personnels.In this review,emphasis is given to two of the crucial technolo-gies in automated pharmaceutical continuous manufacturing,i.e.,process analytical technology(PAT)and self-optimizing algorithm.Research work published in recent 5 years employing advanced PAT tools and self-optimization algorithms is introduced,which represents the great progress that has been made in automated pharmaceutical continuous manufacturing.
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    Recent progress of vaccines administration via microneedles for cancer immunotherapy

    Yuanzheng ChenJiaojiao ZhuJinsong DingWenhu Zhou...
    96-103页
    查看更多>>摘要：Therapeutic cancer vaccines have undergone a resurgence in the past decade.Because of the high level of immune cell accumulation and abundant capillary lymphatic system in the dermis,percutaneous vaccina-tion is considered to be an ideal treatment route.For convenient administration,the recent development of microneedles(MNs)provides a safe,painless,and low-cost transdermal delivery strategy,which could bypass the first-pass metabolism of vaccines for enhanced stability and bioavailability.However,the ther-apeutic effect of MNs-based cancer vaccines is not optimal,which is limited by the complex set of host,tumor,and environmental factors,as well as the limited vaccine loading capacity.Therefore,further im-provements are still required to push their clinical translation.In this critical review,we deliberate on how to improve the therapeutic effect of MNs-based vaccines for cancer immunotherapy,summarize the recent advances in MNs-based cancer vaccination,and provide an overview of various design strategies and mechanisms for active or passive targeting delivery,aiming to develop safer,more effective,and more stable MNs-based cancer vaccines.Finally,we briefly describe the potential of vaccine platforms in com-bination with other therapies,suggest the need to design vaccines according to specific circumstances,and discuss the biosafety of repeated administration for enhancing clinical efficacy.
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    Hydrazone derivatives in agrochemical discovery and development

    Ya WangShengxin GuoLijiao YuWei Zhang...
    104-113页
    查看更多>>摘要：As a common active substructure,hydrazone has attracted increasing attention and is considered essen-tial for pesticide discovery.It has been widely regarded as a potential insecticidal,antibacterial,anti-fungal,antiviral,and herbicidal agent.In this review,we highlight the pesticide versatility of hydrazone fragments and provide a comprehensive summary of the biological activity,structure-activity relation-ship analysis(SARs),and primary mechanism of their analogs.This profile is expected to give valuable information for discovering new pesticides.
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    Key progresses of MOE key laboratory of macromolecular synthesis and functionalization in 2022

    Xumeng DengKaihao ChenKai PangXiaoting Liu...
    114-126页
    查看更多>>摘要：In 2022,The MOE Key Laboratory of Macromolecular Synthesis and Functionalization in Zhejiang Uni-versity had achieved several important results.First,a series of well-defined dinuclear organoboron cat-alysts were developed to precisely control the enchainment of ether and carbonate segments during the copolymerization of CO2 and epoxides.Second,polyester had been synthesized through cationic copoly-merization of cyclic anhydride.Third,ring-opening polymerization of carbon dioxide based valerolactone had been achieved,revealing the prospect of 3-ethylidene-6-vinyltetrahydro-2H-pyran-2-one(EVL)in uti-lizing CO2 and synthesizing functional polymers.Fourth,machine learning methods have been applied to biomaterial research,enabling high-throughput screening of functional biomaterial surfaces for im-plantable devices,and searching for potent antimicrobial peptides in whole combinatorial peptide li-braries.Fifth,methods of characterization of biomacromolecule RNA transcription and manipulation of nucleoside modification were developed.Sixth,artificial enzymes-armed Bifidobacterium Longum probi-otics were established to tune down gut inflammation.Seventh,three-dimensional(3D)printing tech-nologies were used to engineer tough supramolecular hydrogels.Eighth,hydroplastic foaming graphene frameworks for acoustic and conductive polymer composites were provided for application.Ninth,aggre-gate photophysics about the nature of through-space interactions(TSIs)and manipulating their strength in small molecules with non-conjugated structure had been elucidated.Tenth,the forming mechanism of a newfound nested texture in poly(L-lactic acid)(PLLA)spherulitic films had been revealed.Finally,the isotropically dyeing mechanism of KDP single crystals grown from hydrogels have been explored.The related works are reviewed in this paper.
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    Cobalt-loaded carbon nanotubes boosted aerobic ciprofloxacin transformation driven by sulfide:A comprehensive mechanism investigation

    Han-Qing ZhaoPeili LuFei ChenChen-Xuan Li...
    127-134页
    查看更多>>摘要：Sulfide oxidation under aerobic conditions can produce active oxygen for the transformation of organic pollutants in aquatic environments.However,the catalytic performance of transition metal-supported carbon material on this process is poor understood.This study found that Co-loaded carbon nanotubes(CNTs)was able to realize the efficient aerobic transformation of antibiotic ciprofloxacin(CIP)by sulfide,with the pseudo-first order reaction rate constant improved from 0.013 h-1 without catalyst to 0.44-0.71 h-1 with 100 mg/L Co-loaded CNTs.Singlet oxygen(1O2)was the main active specie playing key roles in the process of CIP aerobic transformation with presence of Co-loaded CNTs.Mechanism studies indicated that the excellent electron transfer ability of Co-loaded CNTs might play an important role to promote the electron transfer and facilitate the formation of intermediate H2O2 and 1O2.Additionally,the Co-loaded CNTs/sulfide system effectively reduced the acute toxicity of organic pollutant,and Co-loaded CNTs showed remarkable cycling stability and negligible leaching.This study gives a better understanding for the Co-loaded CNTs mediated aerobic antibiotics transformation by sulfide,and provide a reference for the application of Co-loaded carbon materials on organics aerobic transformation by sulfide.
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    Promoted NH3-SCR activity and hydrothermal stability of Cu-SSZ-50 catalyst synthesized by one-pot method

    Jinpeng DuJingyi WangYulong ShanShichao Han...
    135-139页
    查看更多>>摘要：Nitrogen oxide(NOx)is one of the most critical contaminants in the air,and the control of NOx emis-sion from diesel vehicles is very important.Cu-based small-pore zeolites have already been applied for NOx abatement on diesel vehicles.Among the small-pore zeolites,Cu-SSZ-50 catalysts with good NH3-SCR catalytic activity were believed to have potential for application.In this study,a one-pot synthesis method for Cu-SSZ-50 catalysts was developed for the first time,using the co-templates of Cu-TEPA and 2,6-dimethyl-N-methylpyridinium hydroxide.In this synthesis method,Cu-SSZ-50 with various Cu con-tents can be obtained by adjusting the amount of Cu-TEPA without the need for a further after-treatment process.The addition of Cu-TEPA affected the framework atoms and Cu species,and a lower Si/Al ra-tio and more SCR active Cu species were obtained.The synthesized catalyst with a Cu/Al ratio of 0.40 exhibited over 90％NOx conversion between 200 ℃ and 450 ℃ for the selective catalytic reduction of NOx with NH3(NH3-SCR).Meanwhile,over 80％NOx conversion could be obtained from 250 ℃ to 450 ℃ after hydrothermal aging at 750 ℃ for 16 h.In addition,both L-H and E-R mechanisms were proven to exist for the one-pot-synthesized Cu-SSZ-50 by in situ DRIFTS experiments.The simple synthesis proce-dure,excellent catalytic activity and hydrothermal stability brighten the prospects for the application of Cu-SSZ-50.
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    Enhanced electrochemical oxidation of perfluorooctanoic acid on Ti/SnO2-Sb electrode by surface morphology regulation

    Kaiqiang HouGenwang ZhuYujie FengYanming Liu...
    140-143页
    查看更多>>摘要：Electrochemical oxidation is an effective method to degrade persistent organic pollutants.However,due to the limited catalytic activity of traditional thin film electrodes,the anodic oxidation process is slow and usually requires high energy consumption.Herein,Ti/SnO2-Sb electrode with regulated surface structure was reported to enhance the performance for electrochemical oxidation of persistent organic pollutants.The electrode deposited with SnO2-Sb nanoneedles(Ti/N-SnO2-Sb)showed higher oxidation activity.Its kinetic constant for perfluorooctanoic acid(PFOA)oxidation was 2.0 h-1 and the total organic carbon removal rate was 81.7％(4 h)at a relatively low current density of 6 mA/cm2.Compared with Ti/SnO2-Sb thin film and nanoparticles,Ti/N-SnO2-Sb significantly improved the electrochemical active area and'OH yield,and simultaneously reduced the electron transfer resistance,which enabled it to oxidize PFOA more rapidly even at a lower potential.This work provides a new strategy for promoting the electrochemical oxidation performance.
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    Enhancement of catalytic activity for hydrogenation of nitroaromatic by anionic metal-organic framework

    Qi WuAnyang LiRuibo HeYaxi Wu...
    144-148页
    查看更多>>摘要：Nitroaromatic hydrogenation catalysis without precious metals remains a longstanding challenge.The rate of electron transfer is the crucial factor affecting hydrogenation catalysis.Herein,an ionic Cd-based metal-organic framework(I-Cd-MOF)exhibiting a unique structure with one-dimensional(1D)open-ing nanochannels and good electron transfer ability was synthesized for catalyzing hydrogenation of 4-nitrophenol(4-NP).The catalytic activity of the unique I-Cd-MOF without noble metals is detected,which is higher than most reported noble metal catalysts.Remarkably,the reaction rate of I-Cd-MOF(4.28 min-1)is about 47.6 times higher than that of the Cd-based neutral MOF(N-Cd-MOF)with the similar crystalline structure.Liquid chromatograph mass spectrometer(LC-MS)and theoretical results demonstrate that 4-NP and five intermediates are stabilized in the channels of I-Cd-MOF,which increases the possibility of contact with H*and H2 generated at the Cd sites.The I-Cd-MOF was extended to other nitroaromatic hydrogenation catalysis,which still displays excellent activity.More importantly,the I-MOF@Filter membrane was successfully constructed for continuous hydrogenation catalytic reactions,which maintains a high catalytic performance after 7 cycles of recycling without washing.This work fills in the application of the I-MOFs in hydrogenation catalytic reactions and provides an effective way for the rapid and green degradation of nitroaromatic compounds.
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    Iron single-atom/clusters catalysts derived from iron-rich Enteromorpha after urea-saturation for Fenton-like reaction

    Yujie ZhangSiyi LiuDongdong ChenXing Xu...
    149-152页
    查看更多>>摘要：Fabrication of single atom catalysts(SACs)by a green and gentle method is important for their practi-cal Fenton-like use.In this work,a high effective iron-based catalyst was prepared from the iron-rich Enteromorpha for NPX degradation via peroxymonosulfate(PMS).Both Fe-SACs and iron-clusters was fab-ricated from the intrinsic iron element in Enteromorpha after the urea saturation.The Fe-SACs/clusters can achieve 100％of NPX oxidation within 20 min with the kobs of 0.282 min-1.Quenching tests indi-cated that the radical pathways were not dominated in the catalytic systems,and strong electron transfer process can be induced in the Fe-SACs/clusters+PMS system by using the NPX as electron donor and Fe-SACs/clusters/PMS'complexes as electron acceptor.This result was consistent with the phenomenon ob-served in the galvanic oxidation system.In addition,the Fe-SACs/clusters was deposited onto the ceramic membrane(CM)by the spraying-crosslinking process to form a Fe-SACs/clusters@CM,which showed an effective and continuous NPX degradation in a heterogeneous PMS system.
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    Development and application of photocatalytic coating for roadside NOx mitigation in Hong Kong

    Xinwei LiPengge WangShuwen HanYu Huang...
    153-157页
    查看更多>>摘要：A facile chemical method for the development of photocatalytic coating products was proposed based on practical application perspective for the Hong Kong roadside nitrogen oxides(NOx)mitigation.TiO2-based photocatalytic coating PC-C film with crystallized size of around 5-6 nm was synthesized with the peptization of H2O2.The PC-C coating possesses a super-hydrophilicity surface and is proven to have a NOx degradation rate of 46.8％with an optimum pH level of 7.In addition,the PC-C coating presents a promising photocatalytic NOx degradation compared with other commercially available coating products and P25 when applied on two building materials of poly-methyl methacrylate(PMMA)and concrete sur-face.A weather resistance simulation and a 180-day on-site field trial were carried out the attenuation effects of photocatalytic coating applied in outdoor exposure.Based on epidemiological estimation and field investigation,hospital admissions for respiratory diseases(HARD)and mortality cases(MC)could be reduced with the application of PC-C coating along the street canyon.This work demonstrates the feasibility of air pollution control measures for the local roadside NOx using photocatalytic technology,offering promising health benefits with environmental remediation.
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