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中国化学快报（英文版）
中国化学快报（英文版）

梁晓天

月刊

1001-8417

cclbj@imm.ac.cn

010-63165638

100050

北京市先农坛街1号

中国化学快报（英文版）/Journal Chinese Chemical LettersCSCDCSTPCD北大核心SCI
查看更多>>本刊是由中国科协主管、中国化学会主办、中国医学科学院药物所承办的学术期刊，是由著名化学家梁晓天院士主编。是中国化学界通向世界的窗口，内容覆盖化学全领域。本刊的办刊宗旨是“新、快、准”，我们将坚持这个宗旨，力求及时反映化学研究中各个相关领域内的最新进展及热点问题，主要读者群是科研人员、研究生、大学教师。现已被国内外多家数据库收录，如SCI　Search、Chemical Abstract、Research Alert、Chemistry Citation Index、《日本科技文献速报》、万方数据数字化期刊群、中国学术期刊过刊全文数据库、中国学术期刊（光盘版）、中国学术期刊文摘、中文期刊全文数据库、俄罗斯Рж期刊源等。
正式出版
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    Modularized sulfur storage achieved by 100％space utilization host for high performance lithium-sulfur batteries

    Jun JiangTong GuoWuxin BaiMingliang Liu...
    237-243页
    查看更多>>摘要：Popularization of lithium-sulfur batteries(LSBs)is still hindered by shuttle effect and volume expansion.Herein,a new modularized sulfur storage strategy is proposed to solve above problems and accomplished via employing 100％space utilization host material of cobalt loaded carbon nanoparticles derived from ZIF-67.The modular dispersed storage of sulfur not only greatly increases the proportion of active sulfur,but also inhibits the occurrence of volume expansion.Meanwhile,100％space utilization host material can greatly improve the conductivity of the cathode,provide a larger electrolyte wetting interface and effectively suppress the shuttle effect.Moreover,loaded cobalt particles have high catalytic activity for electrochemical reaction and can effectively improve the redox kinetics.The cell with new cathode host material carbonized at 650 ℃(ZIF-67(650 ℃))exhibits superior rate performance and can maintain a high specific capacity of 950 mAh/g after 100 cycles at 0.2 C,showing a good cycle stability.
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    High-performance localized high-concentration electrolytes by diluent design for long-cycling lithium metal batteries

    Zhe WangLi-Peng HouQian-Kui ZhangNan Yao...
    244-247页
    查看更多>>摘要：Electrolyte design is essential for stabilizing lithium metal anodes and localized high-concentration elec-trolyte(LHCE)is a promising one.However,the state-of-the-art LHCE remains insufficient to ensure long-cycling lithium metal anodes.Herein,regulating the solvation structure of lithium ions in LHCE by weakening the solvating power of diluents is proposed for improving LHCE performance.A diluent,1,1,2,2,3,3,4,4-octafluoro-5-(1,1,2,2-tetrafluoroethoxy)pentane(OFE),with weaker solvating power is in-troduced to increase the proportion of aggregates(an anion interacts with more than two lithium ions,AGG-n)in electrolyte compared with the commonly used 1,1,2,2-tetrafluoroethyl-2,2,3,3-tetrafluoropropyl ether(TTE).The decomposition of AGG-n in OFE-based LHCE intensifies the formation of anion-derived solid electrolyte interphase and improves the uniformity of lithium deposition.Lithium metal batteries with OFE-based LHCE deliver a superior lifespan of 190 cycles compared with 90 cycles of TTE-based LHCE under demanding conditions.Furthermore,a pouch cell with OFE-based LHCE delivers a specific en-ergy of 417Wh/kg and undergoes 49 cycles.This work provides guidance for designing high-performance electrolytes for lithium metal batteries.
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    Multi-electron reaction and fast Al ion diffusion of δ-MnO2 cathode materials in rechargeable aluminum batteries via first-principle calculations

    Lumin ZhengYing BaiChuan Wu
    248-254页
    查看更多>>摘要：Rechargeable aluminum batteries with multi-electron reaction have a high theoretical capacity for next generation of energy storage devices.However,the diffusion mechanism and intrinsic property of Al in-sertion into MnO2 are not clear.Hence,based on the first-principles calculations,key influencing factors of slow Al-ions diffusion are narrow pathways,unstable Al-O bonds and Mn3+type polaron have been identified by investigating four types of δ-MnO2(O3,O'3,P2 and T1).Although Al insert into δ-MnO2 leads to a decrease in the spacing of the Mn-Mn layer,P2 type MnO2 keeps the long(spacious pathways)and stable(2.007-2.030 Å)Al-O bonds resulting in the lower energy barrier of Al diffusion of 0.56 eV.By eliminated the influence of Mn3+(low concentration of Al insertion),the energy barrier of Al migration achieves 0.19 eV in P2 type,confirming the obviously effect of Mn3+polaron.On the contrary,although the T1 type MnO2 has the sluggish of Al-ions diffusion,the larger interlayer spacing of Mn-Mn layer,causing by H2O could assist Al-ions diffusion.Furthermore,it is worth to notice that the multilayer 8-MnO2 achieves multi-electron reaction of 3|e|.Considering the requirement of high energy density,the average voltage of P2(1.76 V)is not an obstacle for application as cathode in RABs.These discover sug-gest that layered MnO2 should keep more P2-type structure in the synthesis of materials and increase the interlayer spacing of Mn-Mn layer for providing technical support of RABs in large-scale energy storage.
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    Observation of high ionic conductivity of polyelectrolyte microgels in salt-free solutions

    Qiangwei WangHuijiao LiuMengjie WangHaojie Zhang...
    255-259页
    查看更多>>摘要：Here,we report an observation that illustrate the potential of polyelectrolyte microgels in salt-free solu-tions to display a high ionic conductivity.Laser light scattering and ionic conductivity tests on very di-lute aqueous dispersions of the microgels indicate that both small size and swollen state of gel particles play vital roles,which should favor the counterions to freely penetrate and leave gel particles,and thus can contribute to the ion-conducting property.Upon discovering this on microgels that are composed of imidazolium-based poly(ionic liquid),we also illustrate the generality of the finding to single lithium-ion polyelectrolyte microgels that are of more technically relevant features for applications,for instance,as injectable liquid"microgel-in-solution"electrolytes of high conductivity(ca.8.2 × 10-2 S/m at 25.0 ℃ for 1.0 × 10-2 g/mL of microgels in a LiNO3-free 1∶1 v/v mixture of 1,2-dioxolane and dimethoxymethane)and high lithium-ion transference number(0.87)for use in the rechargeable lithium-sulfur battery.
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    Transdermal treatment for malignant melanoma by aptamer-modified tetrahedral framework nucleic acid delivery of vemurafenib

    Dexuan XiaoTianyu ChenTianxu ZhangSirong Shi...
    260-267页
    查看更多>>摘要：Melanoma is one of the most malignant skin tumors,whose high invasion is generally associated with BRAF gene mutation.Although new chemotherapeutic drugs,such as vemurafenib,have been developed to inhibit the growth of melanoma,these drugs are usually administered intravenously or orally,result-ing in toxic side effects on major tissues and organs.Tetrahedral framework nucleic acids(tFNAs)are a novel type of DNA nanostructures with excellent biocompatibility and versatility which have been proven to penetrate through skin barrier with ease.In this study,we prepared tFNAs with vemurafenib and connected DNA aptamer AS1411 at the apex of tFNAs(AS1411-tFNAs/vemurafenib).On one hand,AS1411-tFNAs/vemurafenib could kill melanoma cells by blocking the mutated BRAF gene in vitro.Compared with free vemurafenib,AS1411-tFNAs/vemurafenib had no obvious toxicity to normal cells.On the other hand,AS 1411-tFNAs could transfer vemurafenib to cross through the skin barrier and permeate into tumor tis-sues.In vivo,transdermal delivery of AS1411-tFNAs/vemurafenib could inhibit the growth of human A375 melanoma,whose inhibiting effect was stronger than intravenous administration of vemurafenib.These results demonstrated the application prospects of tFNAs combined with chemotherapeutic drugs in skin tumors.
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    Photo-manipulated polyunsaturated fatty acid-doped liposomal hydrogel for flexible photoimmunotherapy

    Xinyue LanJunguang LiangChuran WenXiaolong Quan...
    268-274页
    查看更多>>摘要：Despite the synergy of immune checkpoint blockade(ICB)therapy and photodynamic therapy(PDT)holds great promise as countermeasures against breast cancer,exploring long-term or flexible short-time ther-apeutic strategies in"cold"tumors remains a great challenge.Here,we present a polyunsaturated fatty acid-doped liposomal hydrogel Lp(DHA)@CP Gel loaded with photosensitizer chlorin e6(Ce6)and pro-grammed death-ligand 1 antibody(αPD-L1)for flexible local photoimmunotherapy with merely single-dosed administration.The presence of polyunsaturated fatty acid(docosahexaenoic acid,DHA)doped in particle membrane endows liposomes with flexibly reactive oxygen species(ROS)-responsive release capability,which was attributed to the presence of abundant unsaturated groups.The αPD-L1 was re-peatedly induced to in situ release in response to the PDT under photo-exposure.The immunogenic cell death(ICD)effect of PDT evoked"cold"breast tumor to"hot"one,and then assisted the cascade releasedαPD-L1 to synergistically boost the immunotherapy.After a single dose of peritumoral administration of Lp(DHA)@CP Gel,the on-demand treatment can maximize patient compliance and safety by adjust-ing therapeutic behaviors via a photo on-off switch.This work presents a flexible medication platform,showing promise in improving the objective response rate of ICB therapy and minimizing its systemic toxicity.
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    Formation mechanism for stable system of nanoparticle/protein corona and phospholipid membrane

    Yixin ZhangTing WangJixiang ZhangPengyu Lu...
    275-279页
    查看更多>>摘要：In the physiological environment,nanoparticles(NPs)interact with proteins to form a protein-rich layer on the surface which is called"protein corona".Understanding and analyzing the formation process of protein corona and protein corona-nanoparticles is of great significance for biological related nano re-search.Many separation techniques have been used to analyze the composition of protein corona,but in situ analysis of protein corona is still absent.With the development of detection technology,sum fre-quency generation(SFG)is an effective instrument to analyze the surface protein structure and dynamic changes of protein corona in situ.In this work the molecular mechanism and surface structure effect of the interaction between nanoparticles with surface protein corona(S-NPP)and phospholipid membrane were studied.When S-NPP interacts with phospholipid membrane,the bond affinity network formed by the binding water can stabilize S-NPP around the lipid bilayer.In this process,S-NPP can be found wrapped in the hydration shell.This ultimately leads to a more moderate interaction between particles and phospholipid membrane.
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    Glutathione-depleted cyclodextrin pseudo-polyrotaxane nanoparticles for anti-inflammatory oxaliplatin(Ⅳ)prodrug delivery and enhanced colorectal cancer therapy

    Wenjia WangXingyue HeXiaojie WangTiantian Zhao...
    280-286页
    查看更多>>摘要：Oxaliplatin(Oxa)is the first-line chemotherapeutic drug for the treatment of colorectal cancer(CRC).However,long-term Oxa chemotherapy can induce inflammation and increase the levels of cyclooxygenase-2(COX-2)and prostaglandin E2(PGE2),which can promote tumor metastasis.Moreover,high glutathione(GSH)levels in CRC cells significantly reduce Oxa sensitivity and seriously restrict the clinical application of Oxa.Herein,an Oxa(Ⅳ)prodrug with anti-inflammatory properties(desmethyl naproxe,DN)and GSH-depleting cyclodextrin pseudo-polyrotaxane carriers were prepared and further self-assembled into micellar nanoparticles(designated DNPt@PPRI).The relesae of DN from DNPt@PPRI can reduce the level of PGE2 to inhibit inflammation and tumor metastasis by decreasing COX-2 protein,and also synergize with Oxa to inhibit tumor.More importantly,GSH depletion can reduce the detoxifi-cation of Oxa and further enhance chemotherapy-induced apoptosis.DNPt@PPRI have a good GSH deple-tion ability to enhance the sensitivity of Oxa,indicating a potential in the synergistic chemotherapy and chemo-sensitization of colorectal cancer.
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    β-Lactoglobulin stabilized lipid nanoparticles enhance oral absorption of insulin by slowing down lipolysis

    Lu LiSuticha ChuntaXianzi ZhengHaisheng He...
    287-291页
    查看更多>>摘要：Lipid-based nanocarriers have staged a remarkable comeback in the oral delivery of proteins and pep-tides,but delivery efficiency is compromised by lipolysis.β-Lactoglobulin(β-lg)stabilized lipid nanopar-ticles,including nanoemulsions(NE@β-lg)and nanocapsules(NC@β-lg),were developed to enhance the oral absorption of insulin by slowing down lipolysis due to the protection from β-lg.Cremophor EL sta-bilized nanoemulsions(NE@Cre-EL)were prepared and set as a control.The lipid nanoparticles produced mild and sustained hypoglycemic effects,amounting to oral bioavailability of 3.0％±0.3％,7.0％±1.1％,and 7.7％±0.8％for NE@Cre-EL,NE@β-lg,and NC@β-lg,respectively.Aggregation-caused quenching(ACQ)probes enabled the identification of intact nanoparticles,which were used to investigate the in vivo and intracellular fates of the lipid nanoparticles.In vitro digestion/lipolysis and ex vivo imaging confirmed de-layed lipolysis from β-lg stabilized lipid nanoparticles.NC@β-lg was more resistant to intestinal lipolysis than NE@β-lg due to the Ca2+-induced crosslinking.Live imaging revealed the transepithelial transport of intact nanoparticles and their accumulation in the liver.Cellular studies confirmed the uptake of intact nanoparticles.Slowing down lipolysis via food proteins represents a good strategy to enhance the oral absorption of lipid nanoparticles and thus co-formulated biomacromolecules.
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    Tumor microenvironment-activatable neuropeptide-drug conjugates enhanced tumor penetration and inhibition via multiple delivery pathways and calcium deposition

    Yi CaoXiaojiao GeYuanyuan WeiLulu He...
    292-297页
    查看更多>>摘要：Peptide-drug conjugates have achieved considerable development and application as a novel strategy for targeted delivery of anticancer drugs.Bioactive peptides induced calcium deposition can irreversibly assist inhibition of tumors.However,active regulation of calcium level through signal transduction of bioactive substances has not been reported yet.In this study,novel neuropeptide-doxorubicin conju-gates(NP-DOX)with lysosome-specific acid response were described for neuropeptide Y1 receptor(Y1R)-overexpressed triple-negative breast cancer.The delivery mechanism of NP-DOX was clarified that diverse pathways were involved,including intracellular and intercellular transport.Importantly,up-regulation of Y1R-mediated intracellular calcium level via second messenger inositol triphosphate was presented in NP-DOX treated MDA-MB-231 cells.In vivo antitumor efficacy demonstrated that NP-DOX showed less organ toxicity and enhanced tumor inhibition benefited from its controlled release and Y1R-mediated calcium deposition,compared with free DOX.This bioconjugate is a proof-of-concept confirming that neuropeptide-mediated control of signaling responses in neuropeptide-drug conjugates enables great po-tential for further applications in tumor chemotherapy.
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