首页|Formation mechanism for stable system of nanoparticle/protein corona and phospholipid membrane

Formation mechanism for stable system of nanoparticle/protein corona and phospholipid membrane

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In the physiological environment,nanoparticles(NPs)interact with proteins to form a protein-rich layer on the surface which is called"protein corona".Understanding and analyzing the formation process of protein corona and protein corona-nanoparticles is of great significance for biological related nano re-search.Many separation techniques have been used to analyze the composition of protein corona,but in situ analysis of protein corona is still absent.With the development of detection technology,sum fre-quency generation(SFG)is an effective instrument to analyze the surface protein structure and dynamic changes of protein corona in situ.In this work the molecular mechanism and surface structure effect of the interaction between nanoparticles with surface protein corona(S-NPP)and phospholipid membrane were studied.When S-NPP interacts with phospholipid membrane,the bond affinity network formed by the binding water can stabilize S-NPP around the lipid bilayer.In this process,S-NPP can be found wrapped in the hydration shell.This ultimately leads to a more moderate interaction between particles and phospholipid membrane.

NanoparticlesSum frequency generationProtein coronaPhospholipid membraneInterfacial water

Yixin Zhang、Ting Wang、Jixiang Zhang、Pengyu Lu、Neng Shi、Liqiang Zhang、Weiran Zhu、Nongyue He

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State Key Laboratory of Bioelectronics,National Demonstration Centre for Experimental Biomedical Engineering Education,School of Biological Science and Medical Engineering,Southeast University,Nanjing 210096,China

SceneRay Co.,Ltd.,Suzhou 215123,China

Southeast University and Nanjing Medical Uni-versity Cooperation ProjectSceneRay Co.,LtdNational Key Re-serch and Development Program of China

2017YFA0205304

2024

10.1016/j.cclet.2023.108619

中国化学快报(英文版)
中国化学会

中国化学快报(英文版)

CSTPCD
影响因子：0.771
ISSN：1001-8417
年,卷(期)：2024.35(4)
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