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中国人民解放军军医大学学报（英文版）
中国人民解放军军医大学学报（英文版）

朱诚 王正国 周树复 姚开泰

双月刊

1000-1948

jydxxb@yahoo.com.cn

021-81870791

200433

上海市翔殷路800号

中国人民解放军军医大学学报（英文版）/Journal Journal of Medical Colleges of PLA
查看更多>> 《军医大学学报》（英文版）是由四所军医大学（原第一军医大学现更名为南方医科大学）共同主办的我军高级医药学综合性英文学术刊物，创刊于1986年6月，初为季刊，2003年改为双月刊，采用标准A4开本、正文64页、铜版纸印刷，彩图随文。现为中国科技论文统计源期刊，并被美国《化学文摘》、俄罗斯《文摘杂志》等国际著名检索系统收录。该刊以反映四所军医大学最新的基础和临床医学研究成果为主，旨在加强国际间的学术交流，扩大和提高我国我军和军医大学的学术影响和地位。主编及编委会成员由四所院校的专家教授共同组成，编辑部成员也由四校相关编辑人员共同组成（联络办公室设在第二军医大学），由四校轮流承担责任主编工作。辟有专家论坛、基础研究、临床研究、经验交流、短篇报道、个案报告等栏目。
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    Altered gene expression reveals molecular mechanisms underlying oridonin-induced apoptosis of multiple myeloma LP-1 cells

    ZHAO JingZHANG MeiHE PengchengZHAO Junjie...
    129-138页
    查看更多>>摘要：Objective:To investigate the effect of oridonin on proliferation and invasion of human multiple myeloma LP-1 cells and the underlying mechanism.Methods:LP-1 cells in culture medium in vitro were treated with oridonin at the different concentration.Cell proliferation was measured by Microwave Theory and Techniques (MTT) assay and cell apoptotic rate was detected by flow cytometry.Morphology of cell apoptosis was observed by transmission electron microscope.Expressions of Bax,Bcl-2,Caspase-3,NF-κB as well as I-κB mRNA were detected by real-time PCR.Results:The MTT assays and flow cytometry revealed that oridonin could inhibit the growth of LP-1 cells and cause apoptosis significantly; the suppression was both in timeand dose-dependent manner.Marked morphological changes of cell apoptosis were found under a transmission electron microscope after the cells were treated with oridonin at 25 μmol/L for 24 h.Along with the apoptotic process,Bcl-2,Caspase-3,NF-κB gene expressions were down-regulated (P＜0.05).On the contrast,the Bax and I-κB gene expressions were up-regulated (P＜0.05).Conclusion:Oridonin could inhibit the proliferation of LP-1 cells via inducing apoptosis.We concluded that oridonin induces apoptosis in LP-1 cells via activation of caspase-3 as well as down-regulation of Bcl-2 and up-regulation of Bax expression.The results suggested that oridonin could induce apoptosis of LP-1 cells through mitochondria-and caspase3-dependent pathways.Meanwhile,the inhibition of NF-κB and the activation of I-κB indicate pro-apoptotic stimuli.In one word,oridonin might be an important potential anti-myeloma reagent.
      原文链接:
    • NETL
    • NSTL
    • 万方数据

    Characteristics of short double stranded RNA against hepatitis C virus: a literature-based analysis

    WU Wenbin
    139-151页
    查看更多>>摘要：Objective:To describe the characteristics of short interfering double stranded RNA (dsRNA) against hepatitis C virus (HCV) and to find out the determining factors in design for desirable inhibitory efficacy.Methods:The data were collected and analyzed by retrieval of 229 published short dsRNAs designed for degradation ofHCV RNA.Results:Statistical analyses showed that the most frequently involved short dsRNAs were directing against 5‘NTR/core and genotype lb,accounting for 64.2％ and 69.9％,respectively.Inhibitory efficacy varied with the structural characteristics of short dsRNAs,of which the most potential were those directed against HCV core region with inhibitory efficacy of 70.2％.Moreover,the mean inhibitory efficacy of short dsRNAs with GC contents from 30％ to 52％ was higher than that of those with GC contents out of this range.Conclusion:Based on this pooled data in a relatively large sample,the present results provided clues to design for short dsRNAs with more potent inhibitory efficacy.
      原文链接:
    • NETL
    • NSTL
    • 万方数据

    Serum level of galectin-3 and its clinical significance in patients with chronic Keshan disease

    SUN YuxiaoLIU XinGAO DengfengDONG Xin...
    152-159页
    查看更多>>摘要：Objective:Keshan disease (KD) is a fatal endemic dilated cardiomyopathy with unclear etiology and pathogenesis,and a high mortality in China.Pathologic studies confirmed that different degree of myocardial fibrosis existed in various types of KD.Myocardial fibrosis is an important contributor to the pathophysiology of left ventricular remodeling.Recently,galectin-3 (Gal-3) as a marker of cardiac fibrosis and heart failure was approved by the US FDA.The aim of this study was to evaluate the changes of serum level of Gal-3 in chronic KD (CKD) and their clinical implications.Methods:The levels of serum Gal-3 were measured by using enzyme-linked immunosorbent assay (ELISA) in 37 CKD patients and 32 healthy controls.Echocardiography was used to determine parameter of left ventricular ejection fraction (LVEF) and left ventricular end-diastolic dimension (LVEDD).Results:The serum concentration of Gal-3 ([95.81±18.99] ng/ml versus [48.16±11.09] ng/ml,t=6.906,P＜0.001) and LVEDD ([60.46±7.63] mm versus (42.69±10.66) mm,t=3.61,P＜0.01) were significantly higher,while LVEF ([42.69±10.66]％ versus [62.16±6.38]％,t=4.679,P＜0.01) were significantly lower in CKD patients compared with healthy controls.A negative correlation was found between elevated Gal-3 and lower LVEF (r=-0.882,P＜0.001) and a positive correlation was found between elevated Gal-3 levels and enlarged LVEDD (r=0.834,P＜0.001) or higher NYHA class (r=0.854,P＜0.01) in CKD patients.Conclusion:Serum concentration of Gal-3 is strongly correlated with poorer left ventricular systolic function,enlarged LVEDD and higher New York Heart Association (NYHA) class,which may provide indirectly diagnostic information on myocardial fibrosis and heart function in CKD patients.
      原文链接:
    • NETL
    • NSTL
    • 万方数据

    The pain-related behavior changes correlate with the bone damage in a rat model of rheumatoid arthritis

    ZHENG ShichengWANG KunzhengFAN LihongSHI Zhibin...
    160-173页
    查看更多>>摘要：Objective:In view of the extensive bone damage in rheumatoid arthritis,we used a commonly utilized animal model to detect behavioral changes in pain-related and the bone damage during the early disease,and to explore the correlation between bone damage and pain-related behavioral changes.Methods:Arthritis were induced in Sprague-Dawley (SD) male rats by injecting complete Freund's adjuvant (CFA) into the tails.Pain-related behavior changes were studied using the Hargreaves,VonFrey,and acetone tests on the 0,7,14,day and 28 day after CFA injection.The rats were sacrificed according the same schedule.The bone damage of the fight proximal tibia was studied by microCT scan and bone histological slices.Results:Animals developed soft tissue inflammation and polyarthritis on 7 days after CFA injection,and arthritic score proved obvious arthritis were established within the study period.Mechanical hyperalgesia and cold allodynia were present in the affected hind paw from the 7 day through the 28 day,but the heat hyperalgesia and the mechanical allodynia lasted a short time after CFA injection.Trabecular bone number (Tb.N),Tissue Mineral Content (TMC) and Bone Volume to Tissue Volume (BWTV) in the proximal tibia by microCT scan were also reduced after induction,especial 14 days after CFA injection.The bone histological slices showed the trabecular bone and proteoglycan diminished,the bone damage severity scores became more severely on the 7 day after CFA injection.Using analysis of covariance,these changes had statistical significance compared with baseline.By linear regression analysis demonstrated mechanical hyperalgesia and cold allodynia correlated well with arthritic score,bone damage parameters and bone damage severity scores.Conclusion:Adjuvant-induced arthritis (AA) were observed after CFA injection and lasted within the later experimental period.Pain-related behavioral changes were observed in the early time of AA.Bone damage was also occurred with arthritis development.Pain-related behavioral change correlated well with arthritic score and bone damage parameters.
      原文链接:
    • NETL
    • NSTL
    • 万方数据

    Etiological study of benign esophageal dysphagia with only granulation-report of two cases and litertature review

    GAO RuiJIANG YinaFU JunkeZHANG Guangjian...
    174-182页
    查看更多>>摘要：Etiologies of benign esophageal dysphagia are diverse and a panel of clinical and laboratory investigations should be taken to make the fight diagnosis.We report herein two cases of benign esophageal dysphagia of non-infectious origin.Imaging tests identified changes similar to malignancies,while only inflamed granulation tissue was discovered in biopsy specimens.Surgical resection was finally applied due to severe symptoms and the histological study revealed only granulation tissue.They were diagnosed as idiopathic cases when all the known non-infectious pathogenesis were carefully ruled out by sound examination results.The differetail diagnosis of benign esophageal dysphagia is quite important as observational data shows that medical therapy should be applied in certain pathogenesis,while esophagectomy might be the most effective solution for other etiologies.Subsequently a comparison of the manifestations of the two cases and those of esophageal dysphagia induced by other non-infectious etiologies was done to shine some light on the differencial diagnosis of benign esophageal dysphagia.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

    Endoscopic trans-minor papilla biliary drainage: a case report

    PAN YaminWU JunWANG TiantianHU Bing...
    183-187页
    查看更多>>摘要：In normal physiological anatomy,common bile duct opens in the major papilla and does not communicate with the minor papilla directly.There is little chance to cannulate biliary system via the minor papilla.There was no report of trans-minor papilla biliary drainage in the literature.We presented a case with malignant obstructive jaundice that underwent trans-minor papilla biliary drainage.A 5F super slim nasobiliary tube was inserted into common bile duct successfully through minor papilla during endoscopic retrograde cholangio-pancreatography (ERCP).The patient did not complain abdominal pain or any discomfort after procedure.Biliary drainage was effective (500-800 ml per day).The patient's jaundice relieved significantly during follow-up.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

    Nursing of adverse effects in patients treated with liver resection plus sorafenib for hepatocellular carcinoma: 5 cases report

    WANG HonglingLI JingSHAO Xueqing
    188-192页
    查看更多>>摘要：There were very few reports of adverse effects in patients treated by liver resection in combination with sorafenib.We present 5 cases ofhepatocellular carcinoma treated with liver resection plus sorafenib,trying to observing the adverse effects and seeking the nursing options to the adverse effects.The 5 patients were all males,and the mean age was (38.6±13.4) years.Tumor sizes were (6.7±2.2) cm,and liver function was Child-Pugh class A.Diagnosis of Hepatocellular carcinoma (HCC) was confirmed by postoperative pathology.During the follow-ups,all the 5 patients had different degrees of adverse effects,of which 5 patients had diarrhea,3 had hand-foot skin reaction,1 had hypertension and 1 had alopecie.Diarrhea seems common in these patients,and it appeared early after treatment.For those patients with adverse effects,management measures were given immediately,including nursing interventions and some medicines.Psychological and symptomatic nursing guidance can help patients overcome the adverse effects.No patients suffered dose reduction or treatment discontinuation.
      原文链接:
    • NETL
    • NSTL
    • 万方数据