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中国天然药物
中国天然药物

吴晓明 孙汉董

双月刊

1672-3651

cjnm@cpu.edu.cn

025-83271565、83271568

210009

南京童家巷24号

中国天然药物/Journal Chinese Journal of Natural MedicinesCSCD北大核心CSTPCDSCI
查看更多>>本刊以刊登国家重大基金项目、国际合作项目的原创性成果为特色，旨在为具有独特优势的中药、草药、海洋药物、生化药物、微生物药物、民族药物、民间药物的创新研究提供有效载体。全面反映天然药物各学科研究与发展前沿，刊登来源于天然的药物资源与质量、药物化学、药理学、毒理学、药剂学、药物分析学、生物化学、微生物学、分子生物学、药物与临床、药事法规等及其相关学科研究原著，报道天然药物研究热点、难点及新技术、新方法的应用。解析新机理，提供新思路。内容突出创新性、前瞻性、科学性、实用笥。力求反映天然药物研究的最高水平。
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    Curvularin derivatives from hydrothermal vent sediment fungus Peni-cillium sp.HL-50 guided by molecular networking and their anti-inflammatory activity

    Chunxue YuZixuan XiaZhipeng XuXiyang Tang...
    119-128页
    查看更多>>摘要：Guided by molecular networking,nine novel curvularin derivatives(1-9)and 16 known ana-logs(10-25)were isolated from the hydrothermal vent sediment fungus Penicillium sp.HL-50.Notably,compounds 5-7 represented a hybrid of curvularin and purine.The structures and absolute configurations of compounds 1-9 were elucidated via nuclear magnetic reson-ance(NMR)spectroscopy,X-ray diffraction,electronic circular dichroism(ECD)calculations,13C NMR calculation,modified Mosher's method,and chemical derivatization.Investigation of anti-inflammatory activities revealed that compounds 7-9,11,12,14,15,and 18 exhibited significant suppressive effects against lipopolysaccharide(LPS)-induced nitric oxide(NO)production in murine macrophage RAW264.7 cells,with IC50 values ranging from 0.44 to 4.40μmol·L-1.Furthermore,these bioactive compounds were found to suppress the expression of inflammation-related proteins,including inducible NO synthase(iNOS),cyclooxygenase-2(COX-2),NLR family pyrin domain-containing protein 3(NLRP3),and nuclear factor kappa-B(NF-κB).Additional studies demonstrated that the novel compound 7 possessed potent anti-inflammatory activity by inhibiting the transcription of inflammation-related genes,downreg-ulating the expression of inflammation-related proteins,and inhibiting the release of inflam-matory cytokines,indicating its potential application in the treatment of inflammatory dis-eases.
      原文链接:
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    • NSTL
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    CHINESE JOURNAL OF NATURALMEDICINES Notes for Authors

    后插1-后插2页
      原文链接:
    • NETL
    • NSTL
    • 万方数据