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癌症生物学与医学（英文版）
癌症生物学与医学（英文版）

郝希山

季刊

2095-3941

editor@cancerbiomed.org

022-23522919

300060

天津市河西区体院北环湖西路天津市肿瘤医院C座综合楼三楼

癌症生物学与医学（英文版）/Journal Cancer Biology & MedicineCSCDCSTPCD北大核心SCI
查看更多>>Cancer Biology & Medicine is a peer-reviewed open-access journal of Chinese Anti-cancer Association (CACA), which is the leading professional society of oncology in China. The journal quarterly provides innovative and significant information on biological basis of cancer, cancer microenvironment, translational cancer research, and all aspects of clinical cancer research. The journal also publishes significant perspectives on indigenous cancer types in China. The scope covers the following topics:● Cancer epigenetics● Cancer stem cell● Improved in vivo and in vitro cancer models● Cancer prevention and epidemiology● Biomarkers for predicting drug response● Mechanism of drug sensitivity and resistance● New approaches for cancer detection and diagnosis● Oncology clinical trials● Targeted therapy● Multidisciplinary treatment for cancerAuthor benefits: ● Easy online submission via Editorial Manager● Efficient and professional peer-review by expert referees from around the world● Rapid pre-print online publication● No charge for publication and Open Access● International visibility - the journal is available free online
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    Deciphering the cell surface glyco-code:a promising perspective on unveiling the vulnerability of cancer stem cells

    Yuanyan WeiAnning WeiYirong LiYuerong Yang...
    963-969页
      原文链接:
    • NETL
    • NSTL
    • 万方数据

    PD-1 and LAG-3 dual blockade:emerging mechanisms and potential therapeutic prospects in cancer

    Xiangyu QiuZhaoan YuXiaoqing LuXin Jin...
    970-976页
      原文链接:
    • NETL
    • NSTL
    • 万方数据

    Tumor-related fungi and crosstalk with gut fungi in the tumor microenvironment

    Yue WangYiwen WangYuhang ZhouYun Feng...
    977-994页
    查看更多>>摘要：Most studies on the human gut microbiome have focused on the bacterial fraction rather than fungal biomics,which as resulted in an incomplete understanding of the fungal microbiome.Recent advances in microbiota detection and next-generation sequencing technology have boosted an increase in research on fungi.Symbiotic fungi have become increasingly influential in health and disease and modulate various physiologic functions within the host.Fungal infections can result in high morbidity and mortality rates and are life-threatening in some immunocompromised patients.In addition to bacterial dysbiosis,alterations in fungal communities are important and have been linked to many diseases,including asthma,mental illness,and various cancers.When investigating cancer it is imperative to consider the role of fungi alongside viruses and bacteria.This review examined the impact of intestinal fungi and peri-tumor fungi on tumorigenesis,cancer progression,and response to anticancer therapies.The review highlights the specific involvement of some fungal species in cancers include digestive tract tumors such as colorectal,pancreatic,liver,and gastric cancers,as well as non-digestive tract tumors such as lung,melanoma,breast,and ovarian cancers.Furthermore,fungal mechanisms of action,including fungus-host recognition and immune regulation,biofilm formation,toxin and metabolite production in the tumor microenvironment,and the complex effects of fungus-bacteria interactions on tumorigenesis and development,highlight the significance of potential biomarkers in cancer diagnosis and treatment.
      原文链接:
    • NETL
    • NSTL
    • 万方数据

    Adenosine signaling in tumor-associated macrophages and targeting adenosine signaling for cancer therapy

    Lei YangYi ZhangLi Yang
    995-1011页
    查看更多>>摘要：This review examined the critical role of adenosine signaling in modulating the behavior of tumor-associated macrophages(TAMs),a key determinant of the tumor microenvironment(TME).Adenosine is an immunosuppressive metabolite that is highly enriched in the TME due to elevated expression of adenosine triphosphatase(ATPase).Adenosine influences polarization of TAMs through A2A and A2B receptors,which drives a phenotype that supports tumor progression and immune evasion.The adenosine-mediated regulation of TAMs significantly suppresses the TME,dampening the efficacy of current immunotherapies.Targeting the adenosine pathway has shown potential in preclinical studies through reversal of the immunosuppressive microenvironment and antitumor immune response enhancement.Clinical trials are currently underway to determine the impact of A2A receptor antagonists,and CD39 and CD73 inhibition,enzymes that are pivotal in adenosine production,in various cancers.The current understanding of the CD39-CD73-adenosine axis in TAM regulation and the emerging strategies targeting adenosine signaling pathway for therapeutic intervention are the subjects of this review.The current clinical trials focusing on adenosine pathway inhibitors in combination with existing therapies to improve clinical outcomes are summarized and the need for continued research to refine these approaches for cancer treatment is emphasized.
      原文链接:
    • NETL
    • NSTL
    • 万方数据

    Luteinizing hormone-releasing hormone receptor agonists and antagonists in prostate cancer:effects on long-term survival and combined therapy with next-generation hormonal agents

    Jinge ZhaoJunru ChenGuangxi SunPengfei Shen...
    1012-1032页
    查看更多>>摘要：Prostate cancer is a leading cause of cancer-related death in men worldwide.Luteinizing hormone-releasing hormone receptor(LHRH-R)agonists and antagonists are known to achieve castration-level testosterone suppression;however,long-term data comparing the survival benefits of these therapies are insufficient to inform treatment decisions.Furthermore,the advent of next-generation hormonal agents(NHAs),such as abiraterone and enzalutamide,have shifted the paradigm of managing prostate cancer.Although LHRH-R agonists and antagonists remain the cornerstone treatment across various stages of prostate cancer,they are increasingly administered with NHAs,because the combination treatment confers a survival advantage.Nevertheless,the differences in efficacy and safety profiles among various combinations of LHRH-R agonists and antagonists and NHAs remain unclear.Hence,this narrative review is aimed at providing a comprehensive overview of the long-term outcomes of various LHRH-R agonists and antagonists.Key data from major clinical studies are summarized,categorized by disease stage.LHRH-R agonists and antagonists,particularly goserelin,have demonstrated long-term survival benefits in patients with localized and locally advanced prostate cancer.The clinical outcomes of different LHRH-R agonists and antagonists in combination with NHAs have also been evaluated.Among the various combinations,goserelin plus abiraterone appears to have a manageable safety profile with relatively low rates of hot flushes and fatigue.Overall,long-term survival data and safety profiles should be considered in selecting optimal combination therapies for prostate cancer treatment.
      原文链接:
    • NETL
    • NSTL
    • 万方数据

    Impact of immunosuppressants on tumor pulmonary metastasis:new insight into transplantation for hepatocellular carcinoma

    Jinyan ChenHuigang LiJianyong ZhuoZuyuan Lin...
    1033-1049页
    查看更多>>摘要：Pulmonary metastasis is a life-threatening complication for patients with hepatocellular carcinoma(HCC)undergoing liver transplantation(LT).In addition to the common mechanisms underlying tumor metastasis,another inevitable factor is that the application of immunosuppressive agents,including calcineurin inhibitors(CNIs)and rapamycin inhibitors(mTORis),after transplantation could influence tumor recurrence and metastasis.In recent years,several studies have reported that mTORis,unlike CNIs,have the capacity to modulate the tumorigenic landscape post-liver transplantation by targeting metastasis-initiating cells and reshaping the pulmonary microenvironment.Therefore,we focused on the effects of immunosuppressive agents on the lung metastatic microenvironment and how mTORis impact tumor growth in distant organs.This revelation has provided profound insights into transplant oncology,leading to a renewed understanding of the use of immunosuppressants after LT for HCC.
      原文链接:
    • NETL
    • NSTL
    • 万方数据

    MicroRNA-384 radiosensitizes human non-small cell lung cancer by impairing DNA damage response and repair signaling,which is inhibited by NF-κB

    Yanchen SunJing WangMinghan QiuJinlin Zhao...
    1050-1066页
    查看更多>>摘要：Objective:Radiotherapy has achieved remarkable effects in treating non-small cell lung cancer(NSCLC).However,radioresistance remains the major obstacle to achieving good outcomes.This study aims at identifying potential targets for radiosensitizing NSCLC and elucidating the underlying mechanisms.Methods:Lentivirus-based infection and CRISPR/Cas9 technology were used to modulate the expression of microRNA-384(miR-384).Cell clonogenic formation assays and a xenograft tumor model were used to analyze radiosensitivity in NSCLC cells.Fluorescence-activated cell sorting was used to assess the cell cycle and cell death.Immunofluorescence staining,Comet assays,and homologous recombination or non-homologous end-joining I-SceI/GFP reporter assays were used to study DNA damage and repair.Western blotting and quantitative real-time polymerase chain reaction were used to identify the targets of miR-384.Chromatin immunoprecipitation and polymerase chain reaction were performed to evaluate upstream regulators of miR-384.Results:MiR-384 was downregulated in NSCLC.Overexpression of miR-384 increased the radiosensitivity of NSCLC cells in vitro and in vivo,whereas knockout of miR-384 led to radioresistance.Upregulation of miR-384 radiosensitized NSCLC cells by decreasing G2/M cell cycle arrest,inhibiting DNA damage repair,and consequently increasing cell death;miR-384 depletion had the opposite effects.Further investigation revealed that ATM,Ku70,and Ku80 were direct targets of miR-384.Moreover,miR-384 was repressed by NF-κB.Conclusions:MiR-384 is an ionizing radiation-responsive gene repressed by NF-κB.MiR-384 enhances the radiosensitivity of NSCLC cells via targeting ATM,Ku80,and Ku70,which impairs DNA damage repair.Therefore,miR-384 may serve as a novel radiosensitizer for NSCLC.
      原文链接:
    • NETL
    • NSTL
    • 万方数据

    From complexity to clarity:development of CHM-FIEFP for predicting effective components in Chinese herbal formulas by using big data

    Boyu PanHan ZhuJiaqi YangLiangjiao Wang...
    1067-1077页
    查看更多>>摘要：Objective:The presence of complex components in Chinese herbal medicine(CHM)hinders identification of the primary active substances and understanding of pharmacological principles.This study was aimed at developing a big-data-based,knowledge-driven in silico algorithm for predicting central components in complex CHM formulas.Methods:Network pharmacology(TCMSP)and clinical(GEO)databases were searched to retrieve gene targets corresponding to the formula ingredients,herbal components,and specific disease being treated.Intersections were determined to obtain disease-specific core targets,which underwent further GO and KEGG enrichment analyses to generate non-redundant biological processes and molecular targets for the formula and each component.The ratios of the numbers of biological and molecular events associated with a component were calculated with a formula,and entropy weighting was performed to obtain a fitting score to facilitate ranking and improve identification of the key components.The established method was tested on the traditional CHM formula Danggui Sini Decoction(DSD)for gastric cancer.Finally,the effects of the predicted critical component were experimentally validated in gastric cancer cells.Results:An algorithm called Chinese Herb Medicine-Formula vs.Ingredients Efficacy Fitting&Prediction(CHM-FIEFP)was developed.Ferulic acid was identified as having the highest fitting score among all tested DSD components.The pharmacological effects of ferulic acid alone were similar to those of DSD.Conclusions:CHM-FIEFP is a promising in silico method for identifying pharmacological components of CHM formulas with activity against specific diseases.This approach may also be practical for solving other similarly complex problems.The algorithm is available at http://chm-fiefp.net/.
      原文链接:
    • NETL
    • NSTL
    • 万方数据

    Potential treatment approaches for malignant peritoneal mesothelioma:in vivo and in vitro experimental study of natural killer cell immunotherapy

    Heliang WuYi WangYulin LinRu Ma...
    1078-1094页
    查看更多>>摘要：Objective:Malignant peritoneal mesothelioma(MPM)is a rare primary malignant tumor with an extremely poor prognosis that currently lacks effective treatment options.This study investigated the in vitro and in vivo efficacy of natural killer(NK)cells for treatment of MPM.Methods:An in vitro study was conducted to assess the cytotoxicity of NK cells from umbilical cord blood to MPM cells with the use of a high-content imaging analysis system,the Cell Counting Kit-8 assay,and Wright-Giemsa staining.The level of NK cell effector molecule expression was detected by flow cytometry and enzyme-linked immunosorbent assays.The ability of NK cells to kill MPM cells was determined based on live cell imaging,transmission electron microscopy,and scanning electron microscopy.An in vivo study was conducted to assess the efficacy and safety of NK cell therapy based on the experimental peritoneal cancer index,small animal magnetic resonance imaging,and conventional histopathologic,cytologic,and hematologic studies.Results:NK cells effectively killed MPM cells through the release of effector molecules(granzyme B,perforin,interferon-γ,and tumor necrosis factor-α)in a dose-and density-dependent manner.The NK cell killing process potentially involved four dynamic steps:chemotaxis;hitting;adhesion;and penetration.NK cells significantly reduced the tumor burden,diminished ascites production,and extended survival with no significant hematologic toxicity or organ damage in NOG mice.Conclusions:NK cell immunotherapy inhibited proliferation of MPM cells in vitro and in vivo with a good safety profile.
      原文链接:
    • NETL
    • NSTL
    • 万方数据