首页|Impact of immunosuppressants on tumor pulmonary metastasis:new insight into transplantation for hepatocellular carcinoma

Impact of immunosuppressants on tumor pulmonary metastasis:new insight into transplantation for hepatocellular carcinoma

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Pulmonary metastasis is a life-threatening complication for patients with hepatocellular carcinoma(HCC)undergoing liver transplantation(LT).In addition to the common mechanisms underlying tumor metastasis,another inevitable factor is that the application of immunosuppressive agents,including calcineurin inhibitors(CNIs)and rapamycin inhibitors(mTORis),after transplantation could influence tumor recurrence and metastasis.In recent years,several studies have reported that mTORis,unlike CNIs,have the capacity to modulate the tumorigenic landscape post-liver transplantation by targeting metastasis-initiating cells and reshaping the pulmonary microenvironment.Therefore,we focused on the effects of immunosuppressive agents on the lung metastatic microenvironment and how mTORis impact tumor growth in distant organs.This revelation has provided profound insights into transplant oncology,leading to a renewed understanding of the use of immunosuppressants after LT for HCC.

Liver transplantationhepatocellular carcinomalung immune microenvironmentlung metastasisimmunosuppressants

Jinyan Chen、Huigang Li、Jianyong Zhuo、Zuyuan Lin、Zhihang Hu、Chiyu He、Xiang Wu、Yiru Jin、Zhanyi Lin、Renyi Su、Yiyang Sun、Rongsen Wang、Jiancai Sun、Xuyong Wei、Shusen Zheng、Di Lu、Xiao Xu

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Zhejiang University School of Medicine,Hangzhou 310058,China

Department of Hepatobiliary and Pancreatic Surgery,Hangzhou First People's Hospital,Hangzhou 310006,China

School of Basic Medical Sciences and Forensic Medicine,Hangzhou Medical College,Hangzhou 310053,China

The Fourth School of Clinical Medicine,Zhejiang Chinese Medical University,Hangzhou 310063,China

Department of Hepatobiliary and Pancreatic Surgery,Shulan(Hangzhou)Hospital,Hangzhou 310022,China

Department of Hepatobiliary&Pancreatic Surgery and Minimally Invasive Surgery,Zhejiang Provincial People's Hospital(Affiliated People's Hospital),School of Clinical Medicine,Hangzhou Medical College,Hangzhou 310014,China

Institute of Translational Medicine,Zhejiang University School of Medicine,Hangzhou 310029,China

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2024

10.20892/j.issn.2095-3941.2024.0267

癌症生物学与医学(英文版)
中国抗癌协会

癌症生物学与医学(英文版)

CSTPCD
影响因子：1.07
ISSN：2095-3941
年,卷(期)：2024.21(11)