查看更多>>摘要：Intestinal macrophages play crucial roles in both intestinal inflammation and immune homeostasis.They can adopt two distinct phenotypes,primarily determined by environmental cues.These phenotypes encompass the classically activated pro-inflammatory M1 phenotype,as well as the alternatively activated anti-inflammatory M2 phenotype.In regular conditions,intestinal macrophages serve to shield the gut from inflammatory harm.However,when a combination of genetic and environmental elements influences the polarization of these macrophages,it can result in an M1/M2 macrophage activation imbalance,subsequently leading to a loss of control over intestinal inflammation.This shift transforms normal inflammatory responses into pathological damage within the intestines.In patients with ulcerative colitis-associated colorectal cancer(UC-CRC),disorders related to intestinal inflammation are closely correlated with an imbalance in the polarization of intestinal M1/M2 macrophages.Therefore,reinstating the equilibrium in M1/M2 macrophage polarization could potentially serve as an effective approach to the prevention and treatment of UC-CRC.This paper aims to scrutinize the clinical evidence regarding Chinese medicine(CM)in the treatment of UC-CRC,the pivotal role of macrophage polarization in UC-CRC pathogenesis,and the potential mechanisms through which CM regulates macrophage polarization to address UC-CRC.Our objective is to offer fresh perspectives for clinical application,fundamental research,and pharmaceutical advancement in UC-CRC.
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