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期刊信息/Journal information
中华超声影像学杂志
河北医科大学
中华超声影像学杂志

河北医科大学

张运

月刊

1004-4477

cs@hebmu.edu.cn

0311-86266994

050017

河北省石家庄市中山东路361号

中华超声影像学杂志/Journal Chinese Journal of UltrasonographyCSCD北大核心CSTPCD
查看更多>>中华医学会主办。本刊是中华医学会系列期刊中的超声医学专业学术期刊，主要反映国内超声医学研究进展及国外超声医学学术动态；主要报道临床各科超声诊断、超声造影、介入性超声等研究成果,以及组织声学特征、超声生物效应、医用超声声学成像原理等；主要栏目有临床研究、实验研究、技术研究、专家论坛、述评、综述、专题讲座、短篇论著、病例报告、作者?编者?读者等；主要读者为超声医学临床工作者、各科临床医师、超声医学工程技术人员、医用物理学工作者等。
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    体外心脏震波联合超声微泡后处理对心肌缺血再灌注损伤大鼠心肌的保护作用

    苗雅敬薛雅宁王晓旭周虹...
    77-84页
    查看更多>>摘要：目的 探讨体外心脏震波联合六氟化硫微泡后处理对心肌缺血再灌注损伤(MI/RI)大鼠的心肌保护作用，为临床治疗MI/RI提供理论支持。 方法 将32只雄性SD大鼠均分为4组：假手术组(Sham组)、MI/RI组(IR组)、体外心脏震波治疗(CSWT)组(IR＋SW组)和CSWT联合六氟化硫微泡治疗组(IR＋SW＋MB组)，每组8只。IR＋SW组及IR＋SW＋MB组在造模后第1 d、第3 d及第5 d进行治疗干预。在治疗前及治疗后应用超声心动图测量各组大鼠左心室舒张末期内径(LVEDD)、左心室收缩末期内径(LVESD)、左心室射血分数(LVEF)、左心室短轴缩短率(LVFS)。所有大鼠于第7 d取材，应用Masson染色观察心肌纤维化，TUNEL染色观察心肌细胞凋亡。应用Western blot检测梗死边界区心肌凋亡指标Bcl-2、BAX、激活Caspase-3和激活Caspase-9蛋白的表达水平。比较各组间以上指标的差异。 结果 ①治疗前及治疗后各组间大鼠心律及心率无明显变化，心率差异无统计学意义(P>0.05)。②治疗后超声心动图结果显示，与IR组比较，IR＋SW组、IR＋SW＋MB组LVEDD及LVESD依次减小，LVEF及LVFS依次升高，组间两两比较差异有统计学意义(均P<0.05)。③与IR组比较，IR＋SW组、IR＋SW＋MB组心肌纤维化及凋亡程度依次减轻，以IR＋SW＋MB组减轻最明显。定量分析显示，与IR组比较，IR＋SW组、IR＋SW＋MB组心肌细胞凋亡比例依次减少，组间两两比较差异有统计学意义(均P<0.05)。④Western blot检测结果显示，与IR组比较，IR＋SW组、IR＋SW＋MB组Bcl-2水平依次升高，BAX水平及Caspase-3、Caspase-9蛋白的活化水平依次降低，组间两两比较，除IR＋SW组与IR＋SW＋MB组Caspase-3蛋白的活化水平差异无统计学意义(P>0.05)，余组间比较差异有统计学意义(均P<0.05)。 结论 CSWT联合六氟化硫微泡治疗可抑制心肌细胞凋亡，改善左心室重构，提高左心室收缩功能。 Objective To investigate the myocardial protective effect of extracorporeal cardiac shock wave therapy (CSWT) combined with sulfur hexafluoride microbubble post-conditioning on myocardial ischemia-reperfusion injury (MI/RI) in rats, and to provide theoretical support for clinical treatment of MI/RI. Methods A total of 32 male SD rats were randomly divided into 4 groups: sham operation group (Sham group), MI/RI group (IR group), CSWT group (IR+ SW group), and CSWT combined with sulfur hexafluoride microbubble treatment group (IR+ SW+ MB group), with 8 rats in each group. Therapeutic intervention was performed in IR+ SW group and IR+ SW+ MB group on the 1st, 3rd and 5th day after modeling. The left ventricular end-diastolic diameter (LVEDD), left ventricular end-systolic diameter (LVESD), left ventricular ejection fraction (LVEF) and left ventricular fractional shortening (LVFS) of the rats were measured by echocardiography before and after treatment. On the 7th day, myocardial fibrosis was assessed by Masson staining, and cardiomyocyte apoptosis was observed by TUNEL staining. The myocardial apoptotic proteins Bcl-2, BAX, Cleaved-Caspase-3 and Cleaved-Caspase-9 in the infarct boundary area were detected by Western blot. The differences of the above indexes among different groups were compared. Results ①There was no significant change in heart rhythm and heart rate among the groups before and after treatment, and there was no significant difference in heart rate (P>0.05). ②The echocardiographic results after treatment showed that, compared with IR group, LVEDD and LVESD in IR+ SW group and IR+ SW+ MB group decreased in turn, while LVEF and LVFS increased in turn with significant differences between each two groups (allP<0.05). ③Compared with IR group, the degrees of myocardial fibrosis and apoptosis in IR+ SW group and IR+ SW+ MB group were alleviated in turn, and the relief in IR+ SW+ MB group was the most obvious. Quantitative analysis showed that compared with IR group, the proportions of cardiomyocyte apoptosis in IR+ SW group and IR+ SW+ MB group decreased in turn, and there were significant differences between each two groups (allP<0.05). ④The results of Western blot detection showed that compared with IR group, the levels of Bcl-2 in IR+ SW group and IR+ SW+ MB group increased in turn, while the levels of BAX and the activation level of Caspase-3 and Caspase-9 protein decreased in turn. These differences were all statistically significant between each two groups (allP<0.05) except for the activation level of Caspase-3 protein between IR+ SW group and IR+ SW+ MB group (P>0.05). Conclusions CSWT combined with sulfur hexafluoride microbubble therapy can improve left ventricular remodeling and left ventricular systolic function by inhibiting cardiomyocyte apoptosis.

    体外心脏震波六氟化硫微泡心肌缺血再灌注损伤凋亡

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    三维经食管超声心动图诊断右心耳血栓1例

    冯丹白炜孟欣郭富斌...
    85-87页
    查看更多>>摘要：患者女，61岁，1年前查体发现心脏杂音，劳累后感胸闷、气短。查体：心脏浊音界向左侧扩大，听诊心率116次/min，律不齐，心尖部可闻及Ⅲ级收缩期吹风样杂音。心电图提示：快速心房颤动；冠状动脉CT提示：冠状动脉各支未见狭窄及斑块；经胸超声心动图提示：风湿性二尖瓣重度狭窄并钙化，三尖瓣重度关闭不全，右心房、右心室大(右心房左右径46 mm，右心室左右径35 mm)，肺动脉高压(收缩压51 mmHg，1 mmHg＝0.133 kPa)，三尖瓣环收缩期位移10 mm，右心室面积变化分数28%，左心室收缩功能正常。
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    原发性周围神经淋巴瘤超声表现1例

    水苗苗郭稳陈涛
    88-89页
    查看更多>>摘要：患者男，73岁，以左足主动背伸活动受限伴小腿疼痛3年余，近期逐渐加重于2023年3月16日入院，专科查体示：左足下垂畸形，足趾主动背伸活动受限，足背感觉减退。入院后于我科行神经超声检查提示：自大腿中下段至膝部腓总神经呈不均匀瘤样增粗，长约16 cm，粗0.4～0.8 cm，远端累及腓浅神经于肌间走形节段，粗约0.4 cm，神经固有结构尚存在；神经束膜增厚呈异常丛状改变，部分节段神经外膜下可见梭形低回声环绕，短轴呈"煎蛋样"外观，低回声内可测及丰富血流信号(图1)。PET-CT提示患者腓总神经至腓浅神经节段摄取异常增高。组织活检提示弥漫性大B细胞淋巴瘤。考虑患者腓总神经功能丧失时间较长，行腓总神经切除－下肢功能重建术(图2)及术后化疗，术后病理镜下可见中等偏大的淋巴瘤细胞弥漫分布，浸润脂肪组织及神经生长，考虑浸润性弥漫性大B细胞淋巴瘤(图3)。
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