首页期刊导航|中华内分泌代谢杂志
期刊信息/Journal information
中华内分泌代谢杂志
中华内分泌代谢杂志

宁光

月刊

1000-6699

cjem@vip.163.com

021-64315587

200025

上海市瑞金二路197号

中华内分泌代谢杂志/Journal Chinese Journal of Endocrinology and MetabolismCSCD北大核心CSTPCD
查看更多>>1985年创刊，中华医学会主办。本刊是反映我国当代及与国外合作的，在内分泌代谢病学领域内临床与科研最新成果的高级学术刊物。在强调刊文的先进性、科学性与新颖性的同时，也十分重视临床的实用性和论文的可读性。本刊设指南与共识、述评、专论、论坛、临床研究、基础研究、综述、讲座、临诊应对、当年学术进展与动态、临床经验交流、新药研究、学术争鸣及国外期刊论文评论等栏目。本刊的读者对象主要为各级从事临床和基础内分泌代谢病学工作的医、教、研人员及研究生，以及内、外、儿、妇科以及神经、泌尿、老年、营养等相关科室的人员。
正式出版
收录年代

    两例家族性醛固酮增多症Ⅲ型患者的遗传学及临床特点

    王宇童安莉高寅洁崔云英...
    164-167页
    查看更多>>摘要：家族性醛固酮增多症Ⅲ型极其罕见，国内尚无报道。本文报道2例家族性醛固酮增多症Ⅲ型(FH-Ⅲ)病例，患者均在儿童早期出现严重高血压和低钾血症，1例患者的肾上腺明显增大并在20岁时出现库欣综合征的临床表现，双肾上腺切除后患者的症状完全缓解；另1例患者的影像学显示肾上腺正常，用螺内酯治疗后患者的血压和血钾均得到良好控制。这2例患者均存在KCNJ5胚系突变，分别为c．433G>C，p.Glu145Gln和c.452G>A，p.Gly151Glu。 Familial hyperaldosteronism type Ⅲ(FH-Ⅲ) is extremely rare, and there are no reported cases in China. Herein, we reported two cases with FH Ⅲ, both of which presented with severe hypertension and hypokalemia in their early childhood. One patient had significantly enlarged adrenal glands and developed clinical manifestations of Cushing′s syndrome at the age of 20. Complete relief of symptoms was achieved after bilateral adrenalectomy. The other case had normal adrenal imaging, and with spironolactone treatment, blood pressure and potassium levels were well-controlled. Both cases had germline mutation of KCNJ5 gene which were c. 433G>C(p.Glu145Gln) and c. 452G>A(p.Gly151Glu), respectively.

    家族性醛固酮增多症Ⅲ型KCNJ5基因突变临床特征

      原文链接:
    • 万方数据

    硬骨抑素在代谢性疾病中的研究进展

    邢婷婷李燕文罗娜李春蕾...
    168-172页
    查看更多>>摘要：脂质和葡萄糖代谢在能量稳态中发挥着重要作用，其功能紊乱可诱发代谢综合征的发生，例如肥胖和糖尿病。研究表明，参与脂质和葡萄糖代谢的骨骼属于一种内分泌器官，通过骨源性分子调节全身代谢。其中硬骨抑素(sclerostin)是一种主要由骨细胞产生的蛋白质，具有抑制骨形成的能力，其抗体已成为治疗骨质疏松症的治疗靶点。最近的证据表明硬骨抑素在脂质和葡萄糖代谢紊乱中也发挥着作用。因此，本文基于体外和体内的研究证据，综述了硬骨抑素在脂质和葡萄糖代谢的作用，以及与肥胖和糖尿病之间的关系，总结了硬骨抑素的研究进展，展望其未来在代谢性疾病治疗中的潜在作用。 Lipid and glucose metabolism play crucial roles in maintaining energy homeostasis, and their dysregulation can lead to the development of metabolic disorders, such as obesity and diabetes. Studies indicate that the skeleton, involved in lipid and glucose metabolism, functions as an endocrine organ, regulating systemic metabolism through bone-derived molecules. Sclerostin is a protein mainly produced by osteocytes, possessing the ability to inhibit bone formation, and its antibodies have become therapeutic targets for treating osteoporosis. Recent evidence suggests that sclerostin also plays a role in lipid and glucose metabolism disorders. Therefore, through summarizing in vitro and in vivo researches, this article reviews the role of sclerostin in lipid and glucose metabolism, its relationship with obesity and diabetes, and potential role in the treatment of metabolic diseases in the future.

    硬骨抑素脂代谢糖代谢肥胖糖尿病

      原文链接:
    • 万方数据

    2024年 Journal of Diabetes第1期中文导读

    朱鋐达
    173-176页
    查看更多>>摘要：论著/Original Article
      原文链接:
    • 万方数据

    呼吸系统疾病与继发性骨质疏松症的研究进展

    谭文彬李佳刘明玉路永欣...
    177-182页
    查看更多>>摘要：长期疾病负担及相关药物使用使得骨质疏松症(osteoporosis, OP)成为呼吸系统疾病常见并发症之一。呼吸系统疾病合并OP致病危险因素及抗骨质疏松治疗方案类同于原发性OP，但由于各疾病发病机制不同，其骨量流失的特点、治疗方案均有所区别，需要制定针对性诊疗方案。本文分别从流行病学特征、相关危险因素或可能机制、骨代谢指标变化或骨损害特征、诊疗进展四方面对常见呼吸系统疾病引起继发性OP进行综述，以期为呼吸系统疾病相关继发性OP防治及推进多学科协作模式发展提供参考。 Long-term burden of illness and associated medication usage make osteoporosis(OP) a common complication of respiratory diseases. The pathogenic risk factors and treatment strategies for respiratory diseases related OP are similar to primary OP. However, due to differences in the pathogenesis of each disease, there are distinctions in the characteristics of bone loss and treatment approaches. Therefore, targeted diagnostic and therapeutic plans need to be formulated. This article provides a comprehensive review of secondary OP caused by common respiratory diseases in terms of epidemiological characteristics, related risk factors or possible mechanisms, changes in bone metabolic indexes or characteristics of bone damage, and progress in diagnosis and treatment. The aim of this review is to offer insights into the prevention and treatment of secondary OP related to respiratory diseases and promote the development of a multidisciplinary collaborative approach.

    呼吸系统疾病继发性骨质疏松症流行病学发病机制骨转换标志物骨微结构治疗

      原文链接:
    • 万方数据