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结合医学学报（英文版）
结合医学学报（英文版）

赵伟康

月刊

2095-4964

jcim@163.com

021-81873540

200433

上海市杨浦区翔殷路800号第二军医大学中医系2201室

结合医学学报（英文版）/Journal Journal of Chinese Integrative MedicineCSCDCSTPCD北大核心SCI
查看更多>> 《中西医结合学报》于2003年5月创刊，是中国科技论文统计源期刊、中国科技核心期刊、RCCSE中国权威学术期刊、上海市科协系统优秀科技期刊、全国中医药优秀期刊、美国《医学索引》（Index Medicus/MEDLINE/PubMed）收录期刊。 《中西医结合学报》是开放获取期刊，已被列入《开放获取期刊指南》（Directory of Open Access Journals, DOAJ）,所有被录用的稿件均经过同行评议，同时在纸质印刷版和网络电子版发表。 《中西医结合学报》为月刊，设有院士笔谈、专论、述评、学术探讨、系统评价、临床论著、实验论著、经验交流、医案医话、文献研究、文献综述、学术讲座、医学统计学、中医英译、结合医学概览、医学论文写作、国际动态、会议消息、书评、招聘启事、读者来信等栏目。纸质印刷版于每月15日出版，全球发行；网络电子版与纸质印刷版同步出版。网络电子版具有完善的检索和参考文献链接功能。全球用户可在本刊中英文双语网站无任何限制地检索、阅读和下载全部论文。 《中西医结合学报》在国际最权威的医学文献电子数据库PubMed建有免费全文链接。全球用户可在PubMed免费检索任何一篇论文的摘要和题录，并且可以在PubMed即时链接本刊网站，免费阅读所检索的论文全文。 中西医结合学报杂志社（JCIM Press）是出版者国际链接联合会（Publisher International Linking Association, PILA）和CrossRef的机构会员，与CrossRef成员期刊实现了跨平台链接。《中西医结合学报》的每一篇论文都注册了DOI号，并建有参考文献链接和被引链接。 《中西医结合学报》将以最快的速度，最便捷的方式，最大范围地向世界展示您的研究成果。 我们的办刊方针：坚持学术期刊的导向作用，履行学术期刊的社会责任，倡导科学、严谨、务实、创新的学术风尚。我们的办刊理念：只争朝夕，只求卓越；尽我所能，做到更好。 我们的办刊目的：向世界展示中国中西医结合研究的成果，向中国读者介绍世界结合医学的进展，为全球读者提供一个即时和自由交流的学术平台。 我们的办刊方向：编辑出版国际一流医学期刊，打造国际化精品期刊、品牌期刊。
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    A review of whole-medical systems and holistic care approach for type 2 diabetes and associated metabolic syndrome

    Loveness MakoniIdah T.MandunaAlaisa L.Mbiriri
    199-209页
    查看更多>>摘要：Whole-person care and holistic care approach has been proposed for complementary and integrative health care for type 2 diabetes mellitus.However,some doubts still exist on the feasibility of replicating processes followed in clinical trials and observational studies in real-world settings.This narrative liter-ature review summarized and assessed existing clinical evidence(clinical trials,observational studies,and case reports)describing holistic and integrated care approach in adult and adolescent individuals with type 2 diabetes mellitus in clinical practice.The goal was to highlight existing evidence for imple-mentation and outcomes of whole-medical systems and holistic integrated care approach for type 2 dia-betes mellitus.A nonsystematic literature search was performed on Google Scholar,PubMed,Web of Science,ProQuest and ScienceDirect to identify clinical evidence from different parts of the world,eval-uating the use of whole-medical systems and/or holistic care interventions in clinical practice for man-agement of type 2 diabetes mellitus.Relevant keywords were used in the search.Data were analyzed using content analysis and simple descriptive statistics(percentages).Most of the studies(64% )were mainly conducted in Eastern countries(India,China and Israel)while 36% of the studies were conducted in the Western countries(USA,Netherlands,Canada and Mexico).Lifestyle medicine and integrated naturopathy were shown to be the commonly used whole-medical systems for type 2 diabetes mellitus management.Significant improvements in type 2 diabetes parameters,medication use,other symptoms,and overall feeling of wellness were observed in all studies.This review study revealed limited utilization and/or documentation of whole-medical systems or holistic care treatments for type 2 diabetes mellitus in regions of the world other than eastern countries.Lifestyle medicine,naturopathy,yoga,Ayurveda and traditional Chinese medicine were shown to be effective for type 2 diabetes mellitus,either as an alter-native or as a complementary therapy.
      原文链接:
    • 万方数据
    • 维普

    Iridoids modulate inflammation in diabetic kidney disease:A review

    Tong-yi ZhouNa TianLiu LiRong Yu...
    210-222页
    查看更多>>摘要：In recent years,preclinical research on diabetic kidney disease(DKD)has surged to the forefront of sci-entific and clinical attention.DKD has become a pervasive complication of type 2 diabetes.Given the complexity of its etiology and pathological mechanisms,current interventions,including drugs,dietary modifications,exercise,hypoglycemic treatments and lipid-lowering methods,often fall short in achiev-ing desired therapeutic outcomes.Iridoids,primarily derived from the potent components of traditional herbs,have been the subject of long-standing research.Preclinical data suggest that iridoids possess notable renal protective properties;however,there has been no summary of the research on their efficacy in the management and treatment of DKD.This article consolidates findings from in vivo and in vitro research on iridoids in the context of DKD and highlights their shared anti-inflammatory activities in treating this condition.Additionally,it explores how certain iridoid components modify their chemical structures through the regulation of intestinal flora,potentially bolstering their therapeutic effects.This review provides a focused examination of the mechanisms through which iridoids may prevent or treat DKD,offering valuable insights for future research endeavors.
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    • 万方数据

    Trial characteristics and treatment effect estimates in randomized controlled trials of Chinese herbal medicine:A meta-epidemiological study

    Betty H.WangYa-li LinYin-yan GaoJin-lu Song...
    223-234页
    查看更多>>摘要：Background:Previously published meta-epidemiological studies focused on Western medicine have identified some trial characteristics that impact the treatment effect of randomized controlled trials(RCTs).Nevertheless,it remains unclear if similar associations exist in RCTs on Chinese herbal medicine(CHM).Further,Chinese medicine-related characteristics have not been explored yet.Objective:To investigate trial characteristics related to treatment effect estimates on CHM RCTs.Search strategy:This meta-epidemiological study searched 5 databases for systematic reviews on CHM treatment published between January 2011 and July 2021.Inclusion criteria:An eligible systematic review should only include RCTs of CHM and conduct at least one meta-analysis.Data extraction and analysis:Two reviewers independently conducted data extraction on general character-istics of systematic reviews,meta-analyses and included RCTs.They also assessed the risk of bias of RCTs using the Cochrane risk of bias tool.A two-step approach was used for data analyses.The ratio of odds ratios(ROR)and difference in standardized mean differences(dSMD)with 95% confidence interval(CI)were applied to present the difference in effect estimates for binary and continuous outcomes,respectively.Results:Ninety-one systematic reviews,comprising 1338 RCTs were identified.For binary outcomes,RCTs incorporated with syndrome differentiation(ROR:1.23;95% CI:[1.07,1.39]),adopting Chinese medicine formula(ROR:1.19;95% CI:[1.03,1.34]),with low risk of bias on incomplete outcome data(ROR:1.29;95% CI:[1.06,1.52])and selective outcome reporting(ROR:1.12;95% CI:[1.01,1.24]),as well as a trial size ≥100(ROR:1.23;95% CI:[1.04,1.42])preferred to show larger effect estimates.As for continuous out-comes,RCTs with Chinese medicine diagnostic criteria(dSMD:0.23;95% CI:[0.06,0.41]),judged as high/un-clear risk of bias on allocation concealment(dSMD:-0.70;95% CI:[-0.99,-0.42]),with low risk of bias on incomplete outcome data(dSMD:0.30;95% CI:[0.18,0.43]),conducted at a single center(dSMD:-0.33;95% CI:[-0.61,-0.05]),not using intention-to-treat analysis(dSMD:-0.75;95% CI:[-1.43,-0.07]),and without funding support(dSMD:-0.22;95% CI:[-0.41,-0.02])tended to show larger effect estimates.Conclusion:This study provides empirical evidence for the development of a specific critical appraisal tool for risk of bias assessments on CHM RCTs.
      原文链接:
    • 万方数据

    Efficacy of acupuncture on cancer pain:A systematic review and meta-analysis

    Miguel FariaMónica TeixeiraMaria Jo?o PintoPaulo Sargento...
    235-244页
    查看更多>>摘要：Background:Pain associated with cancer is one of the greatest causes of reduced quality of life in patients.Acupuncture is one of the treatments used to address this issue,with the great advantage of having little or no side effects,especially when compared with pharmacological pain-killers.Objective:The aim of this systematic review and meta-analysis was to evaluate the current evidence regarding the efficacy of acupuncture for cancer pain.Search strategy:Six electronic databases(PubMed,EBSCO,Cochrane Library,Scielo,b-On and Scopus)were searched for relevant articles about pain relief in cancer patients from their beginning until 2022 using MeSH terms such as"acupuncture,""electroacupuncture,""ear acupuncture,""acupuncture anal-gesia,""oncological pain,"and"cancer pain."Inclusion criteria:Studies included were randomized controlled trials(RCTs)where acupuncture was compared with no treatment,placebo acupuncture or usual care.Data extraction and analysis:Three independent reviewers participated in data extraction and evaluation of risk of bias,and a meta-analysis was conducted.The primary outcome was pain intensity,measured with the visual analog scale,numeric rating scale,or brief pain inventory.Secondary outcomes also assessed were quality of life,functionality,xerostomia,pain interference,and analgesic consumption.Results were expressed as standardized mean difference(SMD)with 95% confidence interval(CI).Results:Sixteen RCTs with a total of 1124 participants were included in the meta-analysis,with the majority of the studies presenting a low or unclear risk of bias.Acupuncture was more effective in reduc-ing pain than no treatment(SMD=-0.90,95% CI[-1.68,-0.12]),sham acupuncture(SMD=-1.10,95% CI[-1.59,-0.61])or usual care(SMD=-1.16,95% CI[-1.38,-0.93]).Conclusion:The results of this study suggest that acupuncture may be an effective intervention to reduce pain associated with cancer.Despite some limitations due to the low quality and small sample size of some included studies,as well as the different types and stages of cancer,acupuncture might provide an effective and safe treatment to reduce cancer pain.
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    • 万方数据
    • 维普

    Clinical practice guideline for acupuncture and moxibustion:Allergic rhinitis

    Shi-hao DuSheng ChenShan-ze WangGuan-qun Wang...
    245-257页
    查看更多>>摘要：Acupuncture is one of the most effective complementary therapies for allergic rhinitis(AR)and has been recommended by several clinical practice guidelines(CPGs)for AR.However,these CPGs mentioned acupuncture without making recommendations for clinical implementation and therapeutic protocols,therefore limiting the applicability of acupuncture therapies for AR.Hence,for the benefit of acupuncture practitioners around the world,the World Federation of Acupuncture-moxibustion Societies have initi-ated a project to develop the CPG for the use of acupuncture and moxibustion to treat AR.This CPG was developed according to the Grading of Recommendations Assessment,Development,and Evaluation(GRADE)methodology,referring to the principles of the World Health Organization Handbook for Guideline Development.During the development of the CPG,the guideline development group(GDG)played an important role.The clinical questions,recommendations and therapeutic proto-cols were all formulated by the GDG using the modified Delphi method.The CPG contains recommenda-tions for 15 clinical questions about the use of acupuncture and moxibustion interventions.These include one strong recommendation for the intervention based on high-quality evidence,three conditional rec-ommendations for either the intervention or standard care,and 11 conditional recommendations for the intervention based on very low quality of evidence.The CPG also provides one filiform needle acupuncture protocol and five moxibustion protocols extracted based on the protocols presented in ran-domized controlled trials reviewed by the GDG.
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    • 万方数据
    • 维普

    Clinical practice guideline for acupuncture and moxibustion:Female urinary incontinence

    Chao YangShan-ze WangSheng ChenShuo Du...
    258-269页
    查看更多>>摘要：Urinary incontinence(UI)is a common problem worldwide.It has a major impact on physical and social activities and interpersonal relationships.UI is common in women,but is under-reported and under-treated.It affects the quality of life of female patients severely.Acupuncture and moxibustion have been proposed as potentially effective interventions for female UI.Hence,for the benefit of acupuncture prac-titioners around the world,the World Federation of Acupuncture-moxibustion Societies initiated a pro-ject to develop a clinical practice guideline(CPG)for the use of acupuncture and moxibustion to treat female UI.This CPG was developed according to the Grading of Recommendations Assessment,Development,and Evaluation(GRADE)methodology,referring to the principles of the World Health Organization Handbook for Guideline Development.During the development of the CPG,the guideline development group(GDG)played an important role.The clinical questions,recommendations and ther-apeutic protocols were all formulated by GDG using the modified Delphi method.This CPG contains ten recommendations about the use of acupuncture and moxibustion interventions for ten clinical questions,which include nine conditional recommendations for the intervention and one conditional recommenda-tion for either the intervention or the comparison.This CPG also provides one protocol for conventional filiform needle therapy,two therapy protocols for deep needling stimulation on lumbosacral acupoints,and four moxibustion therapy protocols,based on the protocols presented in randomized controlled trials reviewed by the GDG.
      原文链接:
    • 万方数据

    Efficacy and safety of Huzhang Granule,a compound Chinese herbal medicine,for acute gouty arthritis:A double-blind,randomized controlled trial

    Hao WangSi-ting ChenXiao-jie DingLe Kuai...
    270-278页
    查看更多>>摘要：Background:Acute gouty arthritis(AGA)is an inflammatory joint disease with a high prevalence.Typical medical interventions,including nonsteroidal anti-inflammatory drugs,colchicine and glucocorticoids,can have serious adverse reactions.Huzhang Granule(HZG),a compound Chinese herbal medicine,has been used to treat AGA for more than 30 years with satisfactory effects and no significant adverse reac-tions.However,the efficacy and safety of HZG in AGA patients remains unknown.Objective:The present investigation was designed to examine the efficacy and safety profile of HZG in managing AGA patients.Design,setting,participants and interventions:The current study was conducted as a noninferiority,ran-domized controlled clinical trial on 180 eligible enrolled participants.Participants were randomly assigned into the HZG and etoricoxib groups.Treatments were administered for 5 d,during which the HZG group received HZG and placebo etoricoxib,while the etoricoxib group received etoricoxib and pla-cebo HZG in the same ratio(1∶1).Main outcome measures:The primary outcome was pain experienced by the patient in the gout-afflicted joint from days 2 to 5 of the treatment window.The pain level was measured via a visual analogue scale,ranging from 0 mm to 100 mm.The secondary outcomes comprised joint tenderness and swelling,reduc-tion of inflammatory biomarkers,and the patient's and investigator's global evaluations of therapeutic response.Results:The mean reduction in pain was-51.22 mm(95% confidence interval[CI],[-53.42,-49.03]mm)for the HZG and-52.00 mm(95% CI,[-54.06,-49.94]mm)for the etoricoxib groups.The mean differ-ence between the two groups was 0.78 mm(95% CI,[-2.25,3.81]mm).All additional efficacy endpoints,covering decreased inflammation and pain relief,yielded compelling proof of noninferiority.Patients in the HZG group exhibited a comparatively lower rate of adverse events compared to those in the etori-coxib group(4.44% vs 13.33% ;P ≤ 0.05).Conclusion:HZG and etoricoxib groups demonstrated similar levels of analgesic effectiveness.The safety and efficacy of HZG indicates that it can be used as a potential therapeutic option for treating AGA.Trial registration:Chinese Clinical Trial Registry(ChiCTR2000036970).
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    • 万方数据
    • 维普

    Efficacy and safety of Yiqi Peiyuan granules for improving the short-term prognosis of patients with acute kidney injury:A multicenter,double-blind,placebo-controlled,randomized trial

    Jia-jia WuTian-yi ZhangYing-hui QiMin-yan Zhu...
    279-285页
    查看更多>>摘要：Background:Yiqi Peiyuan(YQPY)prescription,a composite prescription of traditional Chinese medicine,has been used to prevent or delay the continued deterioration of renal function after acute kidney injury(AKI)in some institutions and has shown considerable efficacy.Objective:This is the first randomized controlled trial to assess efficacy and safety of YQPY for improving short-term prognosis in adult patients with AKI.Design,setting,participants and interventions:This is a prospective,double-blind,multicenter,random-ized,and placebo-controlled clinical trial.A total of 144 enrolled participants were randomly allocated to two groups according to a randomization schedule.Participants,caregivers and investigators assessing the outcomes were blinded to group assignment.Patients in the YQPY group received 36 g YQPY granules twice a day for 28 days.Patients in the placebo group received a placebo in the same dose as the YQPY granules.Main outcome measures:The primary outcome was the change in the estimated glomerular filtration rate(eGFR)between baseline and after 4 and 24 weeks of treatment.The secondary outcomes were the change of serum creatinine(Scr)level between baseline and after treatment,and the incidence of end-point events,defined as eGFR increasing by more than 25% above baseline,eGFR＞75 mL/min per 1.73 m2 or the composite endpoint,which was defined as the sum of patients meeting either of the above criteria.Results:Data from a total of 114 patients(59 in the YQPY group and 55 in the control group)were ana-lyzed.The mean changes in eGFR and Scr in weeks 4 and 24 had no difference between the two groups.In further subgroup analysis(22 in the YQPY group and 31 in the control group),the mean change in eGFR after treatment for 4 weeks was 27.39 mL/min per 1.73 m2 in the YQPY group and 5.78 mL/min per 1.73 m2 in the placebo group,and the mean difference between groups was 21.61 mL/min per 1.73 m2(P＜0.001).Thirteen(59.1% )patients in the YQPY group and 5(16.1% )in the placebo group reached the composite endpoints(P=0.002).During the intervention,2 and 4 severe adverse events were reported in the YQPY and placebo groups,respectively.Conclusion:The YQPY granules can effectively improve the renal function of patients 4 weeks after the onset of AKI,indicating that it has good efficacy for improving short-term renal outcomes in patients with AKI.The YQPY granules may be a promising therapy for adults with AKI.
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    • 万方数据
    • 维普

    Ferroptosis inhibitors reduce celastrol toxicity and preserve its insulin sensitizing effects in insulin resistant HepG2 cells

    Jia-jia LiuXue ZhangBang-lan CaiMan-man Qi...
    286-294页
    查看更多>>摘要：Objective:Research has shown that celastrol can effectively treat a variety of diseases,yet when passing a certain dosage threshold,celastrol becomes toxic,causing complications such as liver and kidney damage and erythrocytopenia,among others.With this dichotomy in mind,it is extremely important to find ways to preserve celastrol's efficacy while reducing or preventing its toxicity.Methods:In this study,insulin-resistant HepG2(IR-HepG2)cells were prepared using palmitic acid and used for in vitro experiments.IR-HepG2 cells were treated with celastrol alone or in combination with N-acetylcysteine(NAC)or ferrostatin-1(Fer-1)for 12,24 or 48 h,at a range of doses.Cell counting kit-8 assay,Western blotting,quantitative reverse transcription-polymerase chain reaction,glucose consump-tion assessment,and flow cytometry were performed to measure celastrol's cytotoxicity and whether the cell death was linked to ferroptosis.Results:Celastrol treatment increased lipid oxidation and decreased expression of anti-ferroptosis pro-teins in IR-HepG2 cells.Celastrol downregulated glutathione peroxidase 4(GPX4)mRNA.Molecular docking models predicted that solute carrier family 7 member 11(SLC7A11)and GPX4 were covalently bound by celastrol.Importantly,we found for the first time that the application of ferroptosis inhibitors(especially NAC)was able to reduce celastrol's toxicity while preserving its ability to improve insulin sen-sitivity in IR-HepG2 cells.Conclusion:One potential mechanism of celastrol's cytotoxicity is the induction of ferroptosis,which can be alleviated by treatment with ferroptosis inhibitors.These findings provide a new strategy to block celastrol's toxicity while preserving its therapeutic effects.
      原文链接:
    • 万方数据
    • 维普

    Autophagy plays a pro-apoptotic role in arsenic trioxide-induced cell death of liver cancer

    Zheng-ting DengShu-fang LiangGuo-kai HuangYu-qian Wang...
    295-302页
    查看更多>>摘要：Objective:The effects of arsenic trioxide(As2O3)on hepatocellular carcinoma have been documented widely.Autophagy plays dual roles in the survival and death of cancer cells.Therefore,we investigated the exact role of autophagy in As2O3-induced apoptosis in liver cancer cells.Methods:The viability of hepatoma cells was determined using the MTT assay with or without fetal bovine serum.The rate of apoptosis in liver cancer cells treated with As2O3 was evaluated using flow cytometry,Hoechst 33258 staining,and TUNEL assays.The rate of autophagy among liver cancer cells treated with As2O3 was detected using immunofluorescence,Western blot assay and transmission elec-tron microscopy.Results:Upon treatment with As2O3,the viability of HepG2 and SMMC-7721 cells was decreased in a time-and dose-dependent manner.The apoptosis rates of both liver cancer cell lines increased with the concentration of As2O3,as shown by flow cytometry.Apoptosis in liver cancer cells treated with As2O3 was also shown by the activation of the caspase cascade and the regulation of Bcl-2/Bax expression.Furthermore,As2O3 treatment induced autophagy in liver cancer cells;this finding was supported by Western blot,immunofluorescence of LC3-Ⅱ and beclin 1,and transmission electron microscopy.In liver cancer cells,As2O3 inhibited the phosphoinositide 3-kinase/protein kinase B/mammalian target of rapa-mycin(PI3K/AKT/mTOR)signal pathway that plays a vital role in both apoptosis and autophagy.The PI3K activator SC-79 partially reversed As2O3-induced autophagy and apoptosis.Furthermore,inhibiting autophagy with 3-methyladenine partially reversed the negative effects of As2O3 on cell viability.Serum starvation increased autophagy and amplified the effect of As2O3 on cell death.Conclusion:As2O3 induces apoptosis and autophagy in liver cancer cells.Autophagy induced by As2O3 may have a proapoptotic effect that helps to reduce the viability of liver cancer cells.This study provides novel insights into the effects of As2O3 against liver cancer.
      原文链接:
    • 万方数据
    • 维普