查看更多>>摘要：目的 探讨葡萄糖酸锌、醒脾养儿颗粒联合治疗小儿肠炎的有效性及安全性。 方法 随机对照研究。抽取2022年3月至2023年3月郑州大学第一附属医院收治的肠炎患儿82例作为本次研究对象，按照信封法将其随机分为研究组和对照组，每组41例。两组均予以常规治疗，研究组在此基础上加用葡萄糖酸锌、醒脾养儿颗粒，对照组加用葡萄糖酸锌，记录并对比两组临床疗效、治疗前后炎症因子[包括C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)]水平变化情况及用药期间药物所致不良反应发生情况等指标。 结果 研究组临床治疗总有效率(95.12%，39/41)高于对照组(78.05%，32/41)，P<0.05；两组用药前CRP、TNF-α、IL-6水平比较差异未见统计学意义(P>0.05)，用药后研究组CRP、TNF－α、IL-6水平低于对照组(P<0.05)；两组用药期间各项药物所致不良反应发生率比较差异未见统计学意义(P>0.05)。 结论 葡萄糖酸锌、醒脾养儿颗粒联合应用于小儿肠炎的临床治疗中，有效性、安全性均较理想。 Objective To investigate the efficacy and safety of zinc gluconate combined with Xingpi Yang’er granules in the clinical treatment of pediatric enteritis. Methods This study was a randomized controlled study. Eighty-two children with enteritis admitted to the First Affiliated Hospital of Zhengzhou University from March 2022 to March 2023 were selected as the study subjects. And they were divided into study group and control group by the envelope method, with 41 cases in each group. Both groups received routine treatment. On this basis, the study group was treated with zinc gluconate and Xingpi Yang’er granules, while the control group was treated with zinc gluconate. The clinical efficacy, preoperative and postoperative levels of inflammatory factors, including C-reactive protein (CRP), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), and incidence of drug-induced adverse reactions during treatment were recorded and compared between the two groups. Results The total effective rate in the study group (95.12%, 39/41) was higher than that in the control group (78.05%, 32/41), P<0.05. There was no significant difference in the levels of CRP, TNF-α and IL-6 between the two groups before treatment (P>0.05. The levels of CRP, TNF-α and IL-6 in the study group were lower than those in the control group after treatment (P<0.05). There was no significant difference in the incidence of adverse reactions caused by drugs between the two groups during the treatment period (P>0.05). Conclusions The combination of zinc gluconate and Xingpi Yang’er granules has excellent efficacy and safety in the clinical treatment of pediatric enteritis.
查看更多>>摘要：雌激素是人体中一种重要的类固醇激素，可通过多种雌激素受体介导的基因组和快速非基因组途径诱导多效性细胞反应。其中，快速非基因组途径主要由G蛋白偶联雌激素受体(GPER)通过蛋白激酶途径和第二信使介导。目前越来越多证据表明GPER通过激活多种信号通路参与子宫内膜癌的发生发展。因此，从GPER的角度探讨雌激素促进子宫内膜癌进展的作用机制，将为子宫内膜癌的防治提供新的思路。 Estrogen is an important steroid hormone in the human body, it can induce pluripotent cellular responses through various estrogen receptor mediated genomic and rapid non-genomic pathways. Among them, the rapid non-genomic pathway is mainly mediated by the G protein-coupled estrogen receptor (GPER) through the protein kinase pathway and the second messenger pathway. Currently, increasing evidence suggests that GPER is involved in the occurrence and development of endometrial cancer by activating multiple signaling pathways. Therefore, investigating the mechanism of estrogen promoting the progression of endometrial cancer from the perspective of GPER will provide new ideas for the prevention and treatment of endometrial cancer.
万方数据