查看更多>>摘要：OBJECTIVE:To analyze part of the mechanism of electroacupuncture on Sishencong(EX-HN1)for stroke-related sleep disorders(SSD)and post-stroke cognitive impairment(PSCI).METHODS:Using a randomized controlled trial(RCT)design,72 patients were assigned to the electro-acupuncture(EA)group or the sham acupuncture(SA)group.A healthy control(HC)group was also included.Both groups were given routine rehabilitation treatment.Then,patients in the EA group were given additional electroacupuncture at Sishencong(EX_HN1).Meanwhile,patients in the SA group were given a flat-head needle sham/placebo treatment placed at the bilateral Jianyu(LI15)and Binao(LI14)line midpoints and the Jianyu(LI15)and Jianzhen(S19)line midpoints.Before and after treatment,scales were collected and analyzed.In the second phase of the study,some subjects from the EA group were selected for functional magnetic resonance imaging(fMRI)data acquisition and comparative analysis with the HC group using a non-RCT design.RESULTS:The EA group performed better than the SA group on the Pittsburgh sleep quality index(PSQI),Montreal cognitive assessment basic(MoCA_B),self-rating anxiety scale(SAS),and self-rating depression scale(SDS).Analysis of the fMRI showed that low-frequency(2 Hz)electroacupuncture stimulation at Sishencong(EX_HN1)can restrain frontal sup medial right(SFGmed.R),precuneus right(PCUN.R),and posterior cingulate cortex right(PCC.R)and enhance angular left(ANG.L),parietal inf left(IPL.L)and occipital mid left(MOG.L).The functional connectivity(FC)of SFGmed.R was positively correlated with PSQI.Electroacupuncture stimulation at Sishencong(EX_HN1)can reduce the side efficiency of the whole brain connection with the Thalamus.L,Hippocampus.L,and Occipital.Mid.L.CONCLUSIONS:Low frequency(2 Hz)electroacupuncture stimulation at Sishencong(EX_HN1)can simultaneously improve sleep quality,negative emotions,and cognitive functions,the first two of which may be related to SFGmed.R restraint.Electroacupuncture can make some brain areas approach the physiological bias state,which is characterized by dominant hemispheric enhancement and non-dominant hemispheric weakening.The reduced whole brain connection side efficiency with some key nodes of the brain net may relate to sleep quality improvements in SSD patients.
查看更多>>摘要：Dysmenorrhea is a common gynecological condition that is further divided into two categories,namely primary and secondary dysmenorrhea.Traditional Chinese Medicine(TCM)gives good clinical results for the treatment of dysmenorrhea based on the basic principles of holistic view and syndrome differentiation.However,presently,the clinical practice guidelines in TCM for dysmenorrhea treatment are required.The guideline is formulated in strict accordance with the principles of evidence-based medicine with reference to the General Principles for the Compilation of International Guidelines for Diagnosis and Treatment of Traditional Chinese Medicine Syndromes and General Principles for the Compilation of International Clinical Practice Guidelines for Traditional Chinese Medicine Diseases and accordance with the principles and methods of The Appraisal of Guidelines for Research and Evaluation in China(AGREE-China)and World Health Organization guidelines.This guideline includes clinical issues by literature search and questionnaire survey,and eight background questions and 23 prospect questions were finally created.Based on the evidence retrieval,synthesis,consideration of patient preferences and values,intervention costs,advantages,and disadvantages,recommendations are created using the Delphi method and expert consensus method.This guideline clarified the definition,diagnosis,and TCM syndrome classification for dysmenorrhea,and recommends different TCM treatments based on the level of evidence,including Chinese herbal medicine,Chinese patent medicine,acupuncture,and other auxiliary therapies.The present guideline is an international clinical practice guideline for the treatment of dysmenorrhea using TCM.This guideline will provide substantive evidence and standardized guidance for the treatment of dysmenorrhea using TCM,improve the quality and safety of medical services,and standardize diagnosis and treatment plans for dysmenorrhea.
查看更多>>摘要：Chinese materia medica(CMM)compatibility is one core content in the theory of Traditional Chinese Medicine(TCM),and elaborating the scientific connotation of CMM compatibility is of great significance to promote the modernization of TCM.Self-assembly is the combination of active ingredients into aggregates through non-covalent bonds,such as hydrogen bonding,electrostatic interactions,ionic interactions,and hydrophobic interactions.The complex properties and special structures of CMM components create the basis for self-assembly.The self-assembled materials formed after CMM compatibility is an important part of the material basis for the efficacy of TCM,which can help explain the scientific connotations of CMM compatibility.This review summarizes the self-assembly phenomenon from the perspective of drug pair combinations in recent decades and explains the scientific connotation of CMM compatibility about the material basis,pharmacodynamic changes,and mechanism of action,providing new ideas and methods for the study of TCM.
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