摘要
通过检索近几年中外相关研究文献，概述了大黄素固体脂质纳米粒、包合物、聚合物胶束、脂质体、纳米乳等新型载药系统的制备工艺、工艺优化和包封率情况；同时进一步介绍了大黄素新型制剂在发挥抗肿瘤药效时具有的组织相容性好、治疗浓度低、靶向性好、药物溶解度高、半衰期久等显著优势，为大黄素新型制剂抗肿瘤的进一步研究提供试验依据和理论参考。
Abstract
By retrieving relevant literatures both at home and abroad in recent years, we summarized the preparation process, process optimi-zation and encapsulation of emodin new delivery system, including solid lipid nanoparticles, clathrate compounds, polymeric micelles, lipo-somes, nanoemulsion and so on.Meanwhile, several significant advantages of emodin new formulations when playing an anti-tumor role were further introduced, which had the advantages of good bio-compatibility, low treatment concentration, good target specific selectivity, high solu-bility and long half-life.This research provided experimental evidence and theoretical reference for the further study of anti-tumor of emodin novel preparation.
国家科技期刊平台
NSTL
维普
万方数据