RNAi 3种分子加工机制研究进展
Research Progress of Processing Mechanisms of Three Molecules of RNAi
肖稳 1周玮1
作者信息
- 1. 湖南农业大学植物保护学院,湖南长沙 410128
- 折叠
摘要
RNAi(RNA interference,RNA干扰)是一种高度保守的由小分子RNA介导的基因沉默过程.根据介导RNAi的小RNA长度以及结合Argonaute (AGO)蛋白家族成员的不同,将小RNA分为miRNA (microRNA)、siRNA (small interfering RNA)和piRNA (Piwi-interacting RNA) 3类.根据近年来取得的研究进展,系统地阐述了这3类小RNA的基因组来源及其加工产生机制,归纳总结了这3类小RNA之间的区别和联系,并结合当前RNAi应用于疾病治疗存在的问题提出了自己的看法.RNAi机制的完善对于生物进化、生长发育及癌症等重大疑难疾病治疗具有重要的应用价值.
Abstract
RNAi is a highly conserved gene silencing process mediated by small RNA.Based on the differences of small RNA length and its combined Agonaute (AGO) family members,small RNA is divided into 3 categories:miRNA (microRNA),siRNA (small interfering RNA) and piRNA (Piwi-interacting RNA).Accordingly the reviews,we systematically expound the three small RNA genomic origin and the mechanisms of their production and processing.Furthermore,we summarize the connections among these three small RNAs.Finally,the authors offer a view on problems hindered in RNAi applications on disease treatment of the humans.The perfection of RNAi mechanisms is important to biological revolution,growth and development and treatment of critical illnesses like cancer.
关键词
RNAi/miRNA/siRNA/piRNAKey words
RNAi/miRNA/siRNA/piRNA引用本文复制引用
基金项目
国家自然科学基金青年项目(31301388)
中国博士后科学基金第八批特别资助项目(2015T80870)
出版年
2017
国家科技期刊平台
NSTL
维普
万方数据