摘要
[目的]优化玉米醇溶蛋白硬胶囊的制备工艺.[方法]以玉米黄粉提取的醇溶蛋白为原料,在pH 6.5、干燥温度65℃的最佳条件下,以羟丙基纤维素、聚乙烯吡咯烷酮、山梨醇、甘油、乙醇浓度为考察因素进行单因素试验,在单因素试验基础上,以羟丙基纤维素、聚乙烯吡咯烷酮、山梨醇、甘油4个因素作为自变量,进行4因素3水平正交试验,通过检测胶囊的成品率、脆碎度和崩解时限等指标,确定制备硬胶囊的较优工艺.[结果]玉米醇溶蛋白硬胶囊最佳成囊效果为95％乙醇溶液700 μL、羟丙基纤维素0.20 g、聚乙烯吡咯烷酮0.60 g、20％山梨醇60 μL、20％甘油50μL.[结论]在最佳优化条件下制备出的玉米醇溶蛋白硬胶囊成膜性好,检测的成品率、脆碎度、崩解时限所得结果均符合相关标准.
Abstract
[Objective] To optimize the preparation of zein capsulae operculatae.[Method]With zein extracted from maize yellow powder as raw material,under the best conditions of pH 6.5,drying temperature 65 ℃,hydroxypropyl cellulose,polyvinylpyrrolidone,sorbitol,glycerin as factors to conduct single factor experiment.On the basis of this,the orthogonal test was carried out with the above four factors as independent variables.By detecting the yield,breakage and disintegration time of the capsule,the preparation process was determined.[Result] It turned out that the best preparation process was 95％ alcohol solution 700 μL,hydroxypropyl cellulose 0.20 g,polyvinylpyrrolidone 0.60 g,20％ sorbitol 60 μL,20％ glycerin.50 μL.[Conclusion] Under the best preparation process,zein capsule operculatae has good film forming characteristics,the detection results of yield,breakage and disintegration time limit are all up to standard.
基金项目
吉林省省级经济结构战略调整引导资金专项()
吉林省科技发展计划项目(20160521006H J)
吉林省科技发展计划项目(20160624015H J)
国家科技期刊平台
NSTL
维普
万方数据