Anti-diarrhea Effect of Aqueous Extract of Magnolia officinalis Leaves
[Objective]The research aimed to study the effects of different does of aqueous extraction from Magnolia officinals leaves (AEMOL) on rats diarrhea caused by castor oil, fully utilizing this resource.[Method]Using distilled water as the negative control, loperamide hydrochloride as the positive control,the effects of three different does(low, middle and high) of AEMOL on loose stools rate, onset time, numbers of loose, loose stools series and diarrhea index of the loose rats (5 groups × 6) were studied.[Result]The group of low does AEMOL and the positive control group showed significantly inhibition ratio to diarrhoea. With the does increase, it showed inhibitory effect to the number of loose;besides, AEMOL could also decrease the loose stools rate (the specific effects depend on its does);meanwhile, AEMOL could also significantly reduce the average level of loose stools and diarrhea index.But in general the effect of AEMOL was lower than hydrochloric acid, and it showed no effect on the onset time of mice induced by castor oil.[Conclusion]The AEMOL has a significant inhibitory effect on the rat diarrhea caused by castor oil with dose-effect relationship.
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