Analysis on the Main Pharmacological Effects of Pinellia ternata from Different Origins
[Objective]To compare the main pharmacological effects of Pinellia ternata from different origins,and provide experimental basis for the quality evaluation and clinical use of P. ternata. [Method]The main pharmacological effects of P. ternata from six major production ar-eas in China (Tianmen City,Hubei Province;Nantong City,Jiangsu Province;Tanghe City,Henan Province;Pengxi City,Sichuan Province;Anguo City,Hebei Province and Hezhang City,Guizhou Province) were studied. The models of sputum secretion induced by guaifenesin,cough induced by concentrated ammonia solution,twisting body induced by acetic acid in mice,and ear swelling induced by xylene were es-tablished to investigate the differences in expectorant,antitussive,analgesic,and anti-inflammatory effects of P. ternata from different origins. [Result]In terms of antitussive and expectorant effects,P. ternata from Hezhang City,Nantong City and Pengxi City showed significant in-creased in the secretion of guaifenesin in mice,significantly reduced the number of coughs,and prolonged the cough latency period (P<0.01). In terms of analgesic and anti-inflammatory effects,the P. ternata produced in the Pengxi City,Tianmen City and Tanghe City could significantly prolong the pain latency period,reduced the number of body twists,and significantly reduced the ear swelling (P<0.01). The analgesic and anti-inflammatory effects of P. ternata produced in Hezhang City and Anguo City were secondary,while those produced in Nan-tong City had weaker analgesic and anti-inflammatory effects compared to other production areas. [Conclusion]All six production areas of P. ternata had varying degrees of expectorant,antitussive,analgesicand anti-inflammatory effects. Among them,P. ternata produced in Hezhang City,Nantong City and Pengxi City had significantly better antitussive and expectorant effects compared to P. ternata produced in Tianmen City,Tanghe City and Anguo City. In terms of analgesic and anti-inflammatory effects,P. ternata produced in Pengxi City and Tian-men City were superior to those produced in other regions.
万方数据
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