Using Zuoshi No.1,one of the main potato varieties cultivated in Enping City,Guangdong Province,as the material,a randomized block design was used to study the effects of organic-inorganic compound fertilizer on potato yield,quality,etc. The aim was to provide theoret-ical basis for the rational use of organic-inorganic compound fertilizer in winter potato production in this area. The results showed that T3 treat-ment had significant yield increasing benefits,could ensure the quality of potato tubers,had the highest commercial potato rate,and the high-est economic benefits;and the partial productivity (119.84 kg/kg) and agronomic efficiency (67.10 kg/kg) of this treatment were both the highest.Taking into account potato yield,quality,fertilizer utilization rate,and economic benefits,it is recommended that 900 kg/hm2 of or-ganic-inorganic compound fertilizer be applied as a suitable fertilization scheme for winter potato production.