Observation on the Curative Effect of Macleaya cordata Liquid on Colibacillosis Diarrhea of Piglets
We take the local extremely rich plant Macleaya cordata as the raw material,extract its active ingredient Macleaya cordata,and then make Macleaya cordata liquid to treat piglet coliform diarrhea.140 Meishan weaned piglets aged 22-30 days were randomly divided into 5 groups.Except 10 piglets in the healthy control group,other piglets were artificially inoculated with pathogenic Escherichia coli O149∶K88ac,and were treated with drugs 20 hours later.In the experiment,30 piglets in the low,middle and high dose groups were given Macleaya cordata liquid at a dose of 2.5,5.0 and 10.0 mL for each piglet,and 30 piglets in the drug control group were given Macleaya cordata liquid at a dose of 12.5 mg/kg body weight dissolved in water with apramycin sulfate soluble powder.10 piglets in the control group were infected without drugs.Each group was administered twice a day for 3 consecutive days,and the efficacy was counted 3 days after drug withdrawal.The results showed that the cure rate of the middle dosage group and the drug control group was 90.0%,and the total effective rate of the middle dosage group and the high dosage group was 96.7%,higher than that of the drug control group(93.3% ),but the difference was not significant(P＞0.05).The acute toxicity test showed that the oral LD50 of Macleaya cordata liquid to rats was greater than 5 g/kg,which is very safe.The re-sults showed that the medium and high doses of Macleaya cordata liquid had a good effect on piglet diarrhea.
Macleaya cordata liquidColibacillosisPiglet diarrheaObservation of curative effect
万方数据
维普
