The Mechanism of Treadmill Exercise Activating PGC-1a/FNDC5/BDNF Pathway Delaying the Pathological Process of APP/PS1 Mice
objective:to explore the mechanism of exercise-induced PGC-1a/FNDC5/BDNF signaling pathway in cognitive impairment in APP/PS1 mice.Methods:twelve 4-month-old male APPswe/PS1 transgenic mice and 12 littermates of wild-type mice were selected,and randomly divided into AD control group(AD-C,N=6),AD exercise group(AD-E,N=6),wild control group(WT-C,N=6)and wild exercise group(WT-E,N=6).Mice in WT-C and AD-C groups were reared quietly,and mice in WT-E and AD-E groups were subjected to 10-week moderate intensity treadmill exercise intervention.Western blot was used to detect the expression of PGC-1a,FNDC5,BDNF and Aβ protein in the hippocampus of mice.Results:compared with AD-C group,in AD-E group,the expression level of Aβ protein was significantly decreased(P＜0.01),the expression level of PGC-1a protein was significantly increased(P＜0.01),and the expression level of FNDC5 protein was significantly in-creased(P＜0.01),the expression of BDNF protein was significantly increased(P＜0.01),while the content of AB protein was significantly decreased(P＜0.01).Conclusion:long-term moderate intensity aerobic exercise can acti-vate PGC-1A/FNDC5/BDNF signaling pathway in hippocampus of APP/PS1 mice,decrease the expression of Aβprotein in hippocampus,and improve the ability of spatial learning and memory of APP/PS1 mice.
万方数据
维普
