Analysis of repeated infection and influencing factors of 2190 previously infected persons with SARS-CoV-2 in Anhui Province
Objective To investigate the rate of SARS-CoV-2 reinfection in Anhui Province,China,and to analyze the in-fluencing factors of reinfection,so as to provide a scientific basis for high-risk groups of reinfection identification and formu-lation of targeted intervention measure in the new period.Methods People who living in Anhui Province from January 1,2020 to October 31,2022 and tested positive for SARS-CoV-2 nucleic acid were randomly selected for the questionnaire survey.The general demographic characteristics,vaccination status,onset and medical attendance,and repeated infection status from December 2022 to February 2023 were collected.The influencing factors of reinfection were analyzed by logistic regression.Results A total of 2 190 people with previous SARS-CoV-2 infection were investigated,of uhom 47.99％(1051/2 190)were male and 52.01％(1 139/2 190)were female.The highest proportion of clinical types of the first infec-tion was asymptomatic,accounting for 64.47％(1 412/2 190),followed by mild,middle and severe/critical types,account-ing for 17.85％(391/2 190),16.35％(358/2 190)and 1.33％(29/2 190),respectively.24.84％(544/2 190)were re-infected with SARS-CoV-2 after December 2022(with clinical symptoms or positive nucleic acid/antigen test).Logistic re-gression analysis showed that the patients with severe/critical illness for the first time infection,the patients who have not completed the basic immunization of SARS-Cov-2(OR=1.640,95％CI:1.014-2.654),the time since first time infection was more than two years(OR=11.491,95％CI:8.251-16.004)and between thirteen to twenty-four months(OR=7.000,95％CI:3.554-13.804)were the risk factors of reinfection.Conclusion High risk of repeated infection of SARS-CoV-2 and the clinical classification of the first infection,the time since the first infection and the basic immunization with SARS-CoV-2 vaccine are the main factors affecting the repeated infection.
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