Analysis of influencing factors on drug resistance in tuberculosis patients with positive sputum smear in Huichang County,Jiangxi Province from 2019 to 2022
Objective To analyze the situation and related risk factors of anti-tuberculosis drug resistance in patients with smear positive pulmonary tuberculosis in Huichang County,Jiangxi Province from 2019 to 2022,so as to provide basis for clinical tuberculosis treatment.Methods The related data of drug-resistant pulmonary tuberculosis and non-drug-resistant pulmonary tuberculosis in Huichang County,Jiangxi Province from 2019 to 2022 were collected and analyzed.The sputum samples of smear positive patients were tested for mycobacterium tuberculosis culture and drug sensitivity test.The risk fac-tors of drug resistance of pulmonary tuberculosis were analyzed by SPSS 22.0.Results Among the 1 041 patients with smear positive pulmonary tuberculosis,416(39.96％)were drug-resistant pulmonary tuberculosis and 625(60.04％)were non-drug-resistant pulmonary tuberculosis.The high drug resistance rates of anti-tuberculosis drugs were isoniazid(26.71％),rifampicin(19.60％)and streptomycin(17.20％).Multivariate unconditional logistic regression analysis showed that retreatment(OR=3.780,95％CI:2.870-4.988),irregular medication(OR=3.420,95％CI:2.567-4.549),combined diabetes mellitus(OR=1.850,95％CI:1.420-2.412)and tuberculosis foci in the lungs(OR=3.830,95％CI:2.863-5.120)were risk factors for drug resistance of pulmonary tuberculosis.Conclusion Retreatment,non-standard med-ication,comorbid diabetes mellitus and tuberculosis foci in the lungs are the risk factors for drug resistance of pulmonary tu-berculosis patients.Standardized medication should be used to improve the cure rate of pulmonary tuberculo-sis.Comorbidities of tuberculosis should be treated aggressively to reduce the incidence of anti-tuberculosis drug resistance.
Pulmonary tuberculosisDrug resistanceRisk factorsPrevention and control measures
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