首页|安庆市2022-2023年发热伴血小板减少综合征病原学检测结果分析

安庆市2022-2023年发热伴血小板减少综合征病原学检测结果分析

Analysis of the etiological detection results of severe fever with thrombocytopenia syndrome in Anqing City from 2022 to 2023

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目的 分析安庆市2022-2023年发热伴血小板减少综合征(SFTS)病原学检测结果,为SFTS的科学防控提供基础资料.方法 采用RT-PCR方法对安庆市医疗卫生机构临床送检的520份疑似SFTS病例血清标本开展大别班达病毒(DBV)核酸检测,采用SPSS 25.0对阳性病例流行病学信息进行分析,对部分分离到的病毒株进行S基因测序并构建系统进化树.结果 502份疑似SFTS病例血清样本中,DBV核酸阳性151份,阳性检出率为30.08%;其中男性阳性检出率(27.83%)与女性阳性检出率(31.72%)比为0.88:1;各年龄组阳性检出率差异有统计学意义(x2=15.271,P=0.033),71~80岁组人群占比最高(占38.84%);农民病例占比最高(占84.77%);病例时间分布在4-10月,其中5月份病例占比最高(占27.82%);不同县(区)间的阳性检出率差异有统计学意义(x2=18.080,P=0.021),其中太湖县病例占比最高(占34.75%).测序获得21份毒株S片段基因全长序列,其中F型10株,A型5株,E型5株,B型1株.结论 安庆市及周边县(区)SFTS发病具有一定地域性和季节性,从事农务劳作的中老年群体为高危人群,DBV流行主要基因型为F型.
Objective To analyze the etiological dectection results of severe fever with thrombocytopenia syndrome(SFTS)in Anqing City,and to provide basic data for the scientific prevention and control of SFTS.Methods RT-PCR was used to detect dabie bandavirus(DBV)in 502 serum samples of suspected SFTS cases,and the epidemiological information of con-firmed cases was analyzed by SPSS 25.0.S gene sequencing was performed on some isolated virus strains to construct a phy-logenetic tree.Results Among 502 samples of suspected SFTS cases,151 were positive for DBV RNA,with a positive rate of 30.08%.The ratio of the male positive rate(27.83%)to female positive rate(31.72%)was 0.88:1.There was a sig-nificant difference in the positive rate among all age groups(x2=15.271,P=0.033),and 71-80 years old group accounted for the highest proportion(38.84%).Farmers accounted for 84.77%of the total number of cases.The cases were distributed from April to October,and cases in May accounted for the highest proportion(27.82%).Taihu County had the highest pro-portion of cases(34.75%),and there were statistical differences in the positive rate among different countries(x2=18.080,P=0.021).S fragments of 21 DBV strains were obtained,including 10 strains of the F genotype,5 strains of the A genotype,5 strains of the E genotype,and 1 strain of the B genotype.Conclusion In Anqing City and surrounding areas,the SFTS epidemic showed regional and seasonal distribution.Middle-aged and elderly people engaged in agricultural work are high-risk groups.The main genotype of DBV was F.

Severe fever with thrombocytopenia syndromeDabie bandavirusGenotyping

王爱凤、陈晴晴、刘敏鸿、黄旭、李贤相、高伟林、汪世君

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安庆市疾病预防控制中心微生物检验科,安徽 246000

安徽省疾病预防控制中心微生物检验科,安徽合肥 230601

发热伴血小板减少综合征 大别班达病毒 基因分型

2024

安徽预防医学杂志
安徽省预防医学会 安徽省疾病预防控制中心

安徽预防医学杂志

影响因子:0.43
ISSN:1007-1040
年,卷(期):2024.30(4)