The detection rate and distribution of unexpected antibodies in 2 100 non-remunerated voluntary blood donors
Objective To investigate the positive rate and distribution of unexpected antibody in non-remunerated voluntary blood donors.Methods An accidental antibody screening on 2 100 qualified component blood samples collected by Xu-ancheng People's Hospital from October 2022 to December 2023 before clinical infusion was performed,and then the red blood cell specific antibodies in blood donors with positive screening results was identified.Results A total of 2 100 non-remunerated voluntary blood donors were screened,including 1 271 males,accounting for 60.52％,and 829 females,ac-counting for 39.48％.A total of 12 cases of accidental antibodies were detected,with a positive rate of 0.57％.The positive rate of accidental antibodies in males was 0.16％,which was lower than that in females(1.21％)(xcorrected2=7.958,P=0.005).The positive rate of accidental antibodies in blood donors with a history of blood transfusion was 3.92％,which was higher than that in blood donors without a history of blood transfusion(0.49％)(PFisher=0.033).Among the 12 cases of accidental antibody positive,11 cases were specific antibodies,including anti-E(5 cases),anti-M(3 cases),anti-c(2 ca-ses)and anti-Lea(1 case).One case of non-specific antibody was cold autoantibody.Conclusion It is of great signifi-cance to carry out unexpected antibody screening and identification of voluntary blood donors before blood transfusion,which can reduce cross-matching incompatibility,and the risk of blood transfusion,and ensure the safety of clinical blood use.
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