视黄醇结合蛋白在糖尿病早期肾病诊断中的效果评价
Evaluation of the effect of retinol-binding protein on the diagnosis of early diabetic nephropathy
张益红 1潘明麟 1徐家蓉 1游娜 1叶小龙1
作者信息
- 1. 210011,江苏南京,南京医科大学第二附属医院
- 折叠
摘要
目的 探讨视黄醇结合蛋白(RBP)在糖尿病早期肾病诊断中的意义.方法 选择101例2型糖尿病住院患者为研究对象,建立模型0(仅包括基本资料年龄、性别、BMI、血脂等),模型1(基本资料+常规肾功能指标BUN、Cr、UA)和模型2(基本资料+RBP)等3个模型,采用Logistic 回归及受试者工作特征曲线(ROC曲线),基于曲线下(AUC)面积评价RBP在诊断是否患有糖尿病早期肾病中的效果.结果 模型0,模型1和模型2等3个模型的AUC面积的差异具有统计学意义(AUC0=73.99%,AUC1=76.09%,AUC2=87.39%,P=0.0077).模型2的AUC明显高于模型1及模型0(P2vs1=0.0058,P2vs0=0.0019):而模型1和模型0的AUC差异无统计学意义(P=0.33).结论 RBP在诊断糖尿病早期肾病方面较之BUN、Cr等传统肾功能指标相比,具有更好的诊断效果.
Abstract
Objective To investigate the effect of retinol - binding protein ( RBP ) on the diagnosis of early stage diabetic nephropathy. Methods All 101 cases of type 2 diabetes admitted in our hospital in 2012 were included in this research. Model 0 ( including baseline information: age, sex, BMI and serum lipid level), model 1 ( including baseline information plus common renal function index: BUN, Cr and UA ) and model 2 ( including baseline information plus RBP ) were set up. Logistic regression and the area under curve ( AUC ) statistic of receiver operating characteristic ( ROC ) curve was used to detect the application effect of RBP on the diagnosis of early stage diabetic nephropathy. Results The AUCs of model 0 , model 1 and model 2 were different with statistical significance ( AUCo, =73. 99% , AUC1 = 76. 09% , AUC2 = 87. 39% ,P = 0.0077 ). The AUC2 was statistically higher than AUC1 and AUC0 (P2vsl = 0. 0058, P2vsO = 0. 0019 ). While there was no significant difference between AUC, and AUC0 ( P =0. 3300 ). Conclusion Compared with common renal function indicators, RBP is a better biomarker of early stage diabetic nephropathy.
关键词
视黄醇结合蛋白/糖尿病早期肾病/诊断Key words
Retinol - binding protein/Diabetic nephropathy/Diagnosis引用本文复制引用
出版年
2012
NETL
NSTL
维普
万方数据